The m^(6)A modification involves almost all aspects of RNA biology,including the alternative splicing of mRNA precursors,mRNA transport and stability,and miRNA processing and regulation of target genes.1,2 Alternative...The m^(6)A modification involves almost all aspects of RNA biology,including the alternative splicing of mRNA precursors,mRNA transport and stability,and miRNA processing and regulation of target genes.1,2 Alternative splicing controlling the information storage and RNA translation involves the regulation of various biological processes.3,4,5 Here,we integrated the genomic information of 161 esophageal cancer(EC)samples to comprehensively evaluate the m^(6)A modification patterns and correlated the m^(6)A modification pattern with the prognosis of EC patients,where two distinct m^(6)A modification patterns were proposed.The combined effects of high m^(6)Ascore and low TMB correlated with a better prognosis of EC patients.In addition,we found an inherent correlation between m^(6)A modification and the occurrence of alternative splicing events in EC patients.Altogether,we established a scoring system to quantify the m^(6)A modification pattern with RNA alternative splicing events in individual EC patients(Fig.S1).展开更多
基金supported by the 2022 Anhui Health Research Project Key Project(China)(No.AHWJ2022a017)the Anhui Provincial Natural Science Foundation of China(No.2008085MH299)+3 种基金The fundamental Research Funds for the Central Universities(China)(No.WK9110000008,WK9110000090,WK9110000132 and WK9110000086)The Postdoctoral Research Funding of Anhui Province in 2019(China)(No.2019B371)The Youth Fund of Anhui Cancer Hospital(China)(No.2018YJQN017,2018YJQN004,2020YJQN003 and 2018YJQN004)the Youth Technical Backbone Fund of West Branch of the First Affiliated Hospital of USTC granted to CBZ and LSK,respectively.
文摘The m^(6)A modification involves almost all aspects of RNA biology,including the alternative splicing of mRNA precursors,mRNA transport and stability,and miRNA processing and regulation of target genes.1,2 Alternative splicing controlling the information storage and RNA translation involves the regulation of various biological processes.3,4,5 Here,we integrated the genomic information of 161 esophageal cancer(EC)samples to comprehensively evaluate the m^(6)A modification patterns and correlated the m^(6)A modification pattern with the prognosis of EC patients,where two distinct m^(6)A modification patterns were proposed.The combined effects of high m^(6)Ascore and low TMB correlated with a better prognosis of EC patients.In addition,we found an inherent correlation between m^(6)A modification and the occurrence of alternative splicing events in EC patients.Altogether,we established a scoring system to quantify the m^(6)A modification pattern with RNA alternative splicing events in individual EC patients(Fig.S1).
