In a recent issue of the journal Cancer Cell,Shi et al.reported that glucose metabolism remodels pro-tumoral functions of tumor-associated macrophages(TAMs)to support cancer metastasis and chemoresistance.Mechanistica...In a recent issue of the journal Cancer Cell,Shi et al.reported that glucose metabolism remodels pro-tumoral functions of tumor-associated macrophages(TAMs)to support cancer metastasis and chemoresistance.Mechanistically,the consumption of glucose fuels hexosamine biosynthetic pathway(HBP)and enhances O-GlcNAcylation of Cathepsin B in macrophages,which upon secretion disrupts the tumor microenvironment(TME)[1].展开更多
基金supported in part by grants from the Shenzhen Institute of Advanced Technology (HX) and the National Natural Science Foundation of China (No.32130040) (YHC).
文摘In a recent issue of the journal Cancer Cell,Shi et al.reported that glucose metabolism remodels pro-tumoral functions of tumor-associated macrophages(TAMs)to support cancer metastasis and chemoresistance.Mechanistically,the consumption of glucose fuels hexosamine biosynthetic pathway(HBP)and enhances O-GlcNAcylation of Cathepsin B in macrophages,which upon secretion disrupts the tumor microenvironment(TME)[1].
