Immunometabolism is the intersection of immunology and metabolism.The heme oxygenase(HO)-1 and carbon monoxide(CO)(HO-1/CO)system can be induced by various stresses,including infection,and its function is to relieve s...Immunometabolism is the intersection of immunology and metabolism.The heme oxygenase(HO)-1 and carbon monoxide(CO)(HO-1/CO)system can be induced by various stresses,including infection,and its function is to relieve stresses such as oxidative and inflammatory reactions.Here we demonstrate that the HO-1/CO system is intimately involved in the beneficial modulation of metabolic pathways via the production of ATF4 through an integrative stress response.展开更多
基金This work was supported by the Priority Research Centers Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(2014R1A6A1030318).
文摘Immunometabolism is the intersection of immunology and metabolism.The heme oxygenase(HO)-1 and carbon monoxide(CO)(HO-1/CO)system can be induced by various stresses,including infection,and its function is to relieve stresses such as oxidative and inflammatory reactions.Here we demonstrate that the HO-1/CO system is intimately involved in the beneficial modulation of metabolic pathways via the production of ATF4 through an integrative stress response.
