Colorectal cancer(CRC)is the third most common cancer and the leading cause of cancer death globally.Resistance to therapy is a challenge for CRC treatment.Mesenchymal stem cells(MSCs)have become one of the furthermos...Colorectal cancer(CRC)is the third most common cancer and the leading cause of cancer death globally.Resistance to therapy is a challenge for CRC treatment.Mesenchymal stem cells(MSCs)have become one of the furthermost effective approaches for tumor treatment due to their specific feature;however,their therapeutic function is controversial.Recently,extracellular vesicles(EVs)derived from MSCs(MSCs-EVs)have attracted extensive research attention due to their promising role in CRC treatment.EVs are cell-derived vesicles that transfer different biomolecules between cells,contributing to intracellular communication.MSCs-EVs can suppress CRC by delivering therapeutic agents to tumor cells.Several studies indicate that MSCs-EVs can serve as a drug delivery system for the treatment of different cancers.Various methods are used to modify(engineer)MSCs-EVs for loading therapeutic agents.Modified MSCs-EVs have improved specificity,targeting ability,and immunogenicity compared to synthetic carriers.Furthermore,CRC-EVs participate in regulating different cells,such as immune cells,fibroblasts,and endothelial cells,promoting tumorigenesis.MSCs-EVs-based therapy indicates a high potential in the treatment of cancer;however,the majority of studies have been conducted in the pre-clinical,and their clinical applications need further scrutiny.In this review,we describe the biogenesis of EVs,focusing on the effect of MSCs-EVs on CRC cells and CRC-derived EVs on other cells.Furthermore,MSCs-EVs as a drug delivery system for cancers is also reviewed,and perspectives regarding the therapeutic application of MSCs-EVs are discussed.展开更多
Chronic ethanol consumption is associated with changes in the function and structure of the lungs. The aim of this study was to investigate the effect of chronic ethanol exposure on the lungs and whether ginger extrac...Chronic ethanol consumption is associated with changes in the function and structure of the lungs. The aim of this study was to investigate the effect of chronic ethanol exposure on the lungs and whether ginger extract mitigated pulmonary abnormalities induced by ethanol in rats. Male Wistar rats were divided into the control group, the ethanol group, and the ethanol plus ginger extract group. Six weeks of ethanol treatment increased the proliferation of lung cells, and induced fibrosis, inflammation and leukocyte infiltration. A significant rise in the level of 8-hydroxydeoxyguanosine, NADPH oxidase, and oxidized low-density lipoprotein was also observed. Ginger extract significantly ameliorated the above changes. These findings indicate that ethanol induces abnormalities in the lungs by oxidative DNA damage and oxidative stress, and that these effects can be alleviated by ginger, which may function as an antioxidant and anti-inflammatory agent.展开更多
文摘Colorectal cancer(CRC)is the third most common cancer and the leading cause of cancer death globally.Resistance to therapy is a challenge for CRC treatment.Mesenchymal stem cells(MSCs)have become one of the furthermost effective approaches for tumor treatment due to their specific feature;however,their therapeutic function is controversial.Recently,extracellular vesicles(EVs)derived from MSCs(MSCs-EVs)have attracted extensive research attention due to their promising role in CRC treatment.EVs are cell-derived vesicles that transfer different biomolecules between cells,contributing to intracellular communication.MSCs-EVs can suppress CRC by delivering therapeutic agents to tumor cells.Several studies indicate that MSCs-EVs can serve as a drug delivery system for the treatment of different cancers.Various methods are used to modify(engineer)MSCs-EVs for loading therapeutic agents.Modified MSCs-EVs have improved specificity,targeting ability,and immunogenicity compared to synthetic carriers.Furthermore,CRC-EVs participate in regulating different cells,such as immune cells,fibroblasts,and endothelial cells,promoting tumorigenesis.MSCs-EVs-based therapy indicates a high potential in the treatment of cancer;however,the majority of studies have been conducted in the pre-clinical,and their clinical applications need further scrutiny.In this review,we describe the biogenesis of EVs,focusing on the effect of MSCs-EVs on CRC cells and CRC-derived EVs on other cells.Furthermore,MSCs-EVs as a drug delivery system for cancers is also reviewed,and perspectives regarding the therapeutic application of MSCs-EVs are discussed.
文摘Chronic ethanol consumption is associated with changes in the function and structure of the lungs. The aim of this study was to investigate the effect of chronic ethanol exposure on the lungs and whether ginger extract mitigated pulmonary abnormalities induced by ethanol in rats. Male Wistar rats were divided into the control group, the ethanol group, and the ethanol plus ginger extract group. Six weeks of ethanol treatment increased the proliferation of lung cells, and induced fibrosis, inflammation and leukocyte infiltration. A significant rise in the level of 8-hydroxydeoxyguanosine, NADPH oxidase, and oxidized low-density lipoprotein was also observed. Ginger extract significantly ameliorated the above changes. These findings indicate that ethanol induces abnormalities in the lungs by oxidative DNA damage and oxidative stress, and that these effects can be alleviated by ginger, which may function as an antioxidant and anti-inflammatory agent.
