Relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility:What can we learn from the literature

This article discusses the various blood interactions that may occur with various types of nano drug-loading systems. Nanoparticles enter the blood circulation as foreign objects. On the one hand, they may cause a series of inflammatory reactions and immune reactions, resulting in the rapid elimination of immune cells and the reticuloendothelial system, affecting their durability in the blood circulation. On the other hand, the premise of the drug-carrying system to play a therapeutic role depends on whether they cause coagulation and platelet activation, the absence of hemolysis and the elimination of immune cells. For different forms of nano drug-carrying systems, we can find the characteristics, elements and coping strategies of adverse blood reactions that we can find in previous researches. These adverse reactions may include destruction of blood cells, abnormal coagulation system, abnormal effects of plasma proteins, abnormal blood cell behavior, adverse immune and inflammatory reactions, and excessive vascular stimulation. In order to provide help for future research and formulation work on the blood compatibility of nano drug carriers.

Numerical Simulation Analysis of the Transformer Fire Extinguishing Process with a High-Pressure Water Mist System under Different Conditions

To thoroughly study the extinguishing effect of a high-pressure water mist fire extinguishing system when a transformer fire occurs,a 3D experimental model of a transformer is established in this work by employing Fire Dynamics Simulator(FDS)software.More specifically,by setting different parameters,the process of the highpressure water mist fire extinguishing system with the presence of both diverse ambient temperatures and water mist sprinkler laying conditions is simulated.In addition,the fire extinguishing effect of the employed high-pressure water mist system with the implementation of different strategies is systematically analyzed.The extracted results show that a fire source farther away fromthe centerline leads to a lower local temperature distribution.In addition,as the ambient temperature increases,the temperature above the fire source decreases,while the temperature and the concentrationof theupperflue gas layer bothdecrease.Interestingly,after thehigh-pressurewatermist sprinkler begins to operate,both the temperature distribution above the fire source and the concentration of the flue gas decrease,which indicates that the high-pressure water mist system plays the role of cooling and dust removal.By comparing various sprinkler laying methods,it is found that the lower sprinkler height has a better effect on the temperature above the fire source,the temperature of the upper flue gas layer,and the concentration of the flue gas.Moreover,when the sprinkler is spread over thewhole transformer,the cooling effect on both the temperature above the fire source and the temperature of the upper flue gas layer is good,whereas the change in the concentration of the flue gas above the fire source is not obvious compared to the case where the sprinkler is not fully spread.

Analyzing the Flow Field in the Oil Chamber of a Hydrostatic Guide Rail Used for Ultra-Precision Machining: Numerical Simulation and Performance Optimization

In order to explore the impact of different structural design parameters and environmental factors on the performance of the hydrostatic guide rail,the flow field inside its oil chamber is simulated,which provides direction and guidance for the design and optimization of the guide rail system.Based on the theory of fluid lubrication and the Reynolds equation,numerical simulations are performed through a mathematical model.The results suggest that the bearing capacity of the oil film increases with the oil supply pressure.The film thickness and the film stiffness share a positive correlation.Different oil film thickness and different input pressure parameters can have a significant impact on bearing capacity and oil film stiffness.The correlations identified in the present analysis can be used as a basis to optimize the guide rail design.

A Numerical Study on the Extinguishing Performances of High-Pressure Water Mist on Power-Transformer Fires for Different Flow Rates and Particle Velocities

In order to study the extinguishing performance of high-pressure-water-mist-based systems on the fires originating from power transformers the PyroSim software is used.Different particle velocities and flow rates are considered.The evolution laws of temperature around transformer,flue gas concentration and upper layer temperature of flue gas are analyzed under different boundary conditions.It is shown that the higher the particle velocity is,the lower the smoke concentration is,the better the cooling effect on the upper layer temperature of flue gas layer is,the larger the flow rate is and the better the cooling effect is.

Oral delivery of superoxide dismutase by lipid polymer hybrid nanoparticles for the treatment of ulcerative colitis

Protein-based drugs have received extensive attention in the field of drug research in recent years.However,protein-based drug activity is difficult to maintain during oral delivery,which limits its application.This study developed bifunctional oral lipid polymer hybrid nanoparticles(R8-PEG-PPNPs)that deliver superoxide dismutase(SOD)for the treatment of ulcerative colitis(UC).R8-PEG-PPNPs was composed of PCADK,PLGA,lecithin,and co-modified with stearic acid-octa-arginine and polyethylene glycol.The nanoparticles(NPs)are uniformly dispersed with a complete spherical structure.In vitro stability and release studies showed that R8-PEG-PPNPs exhibited good stability and protection.In vitro cell culture experiments demonstrated that R8-PEG-PPNPs as carriers have no significant toxic effects on cells at concentration below 1000µg/mL and promote cellular uptake.In experiments with ulcerative colitis mice,R8-PEG-PPNPs were able to enhance drug absorption by intestinal epithelial cells and accumulate effectively at the site of inflammation.Its therapeutic effect further demonstrates that R8-PEG-PPNPs are a promising delivery system for oral delivery of protein-based drugs.