Objective:To investigate the role of Runx3 protein and TGF-β<sub>1</sub> in the pathogenesis of irritable bowel syndrome（IBS）,as well as the correlation of these two proteins.Methods:Colonic tissue was ...Objective:To investigate the role of Runx3 protein and TGF-β<sub>1</sub> in the pathogenesis of irritable bowel syndrome（IBS）,as well as the correlation of these two proteins.Methods:Colonic tissue was collected from patients with IBS and normal persons.The colonic expression of Runx3 protein and TGF-β<sub>1</sub> was detected with immunohislochemistry method.Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.Results:Compared with their counterparts,patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β<sub>1</sub>（P】0.05）.Interestingly,there was a significant correlation between Runx3 protein and TGF-β<sub>1</sub> in patients with IBS（P【0.05）.Conclusions:The role of Runx3 protein and TGF-β<sub>1</sub> in the pathogenesis of IBS remains to be further studied.展开更多
Gastric cancer is one of the most common malignancies of the digestive system,and the number of deaths continues to increase.The standardized management of the diagnosis and treatment of gastric cancer is challenging ...Gastric cancer is one of the most common malignancies of the digestive system,and the number of deaths continues to increase.The standardized management of the diagnosis and treatment of gastric cancer is challenging due to the great differences in the diagnosis and treatment of gastric cancer in different regions.The Gastric Cancer Expert Committee of the National Cancer Quality Control Center(NCQCC)identified a lack of authoritative quality control standards as an opportunity to utilize its multidisciplinary membership to improve the standardized diagnosis and treatment of gastric cancer.The Gastric Cancer Expert Committee of the NCQCC aims to promote quality control and national standardization,uniformity,and normalization of gastric cancer diagnosis and treatment,which ultimately improved the survival rate and quality of life of gastric cancer patients.A panel of experts with gastrointestinal cancer surgery,gastrointestinal cancer medicine,medical imaging,pathology and radiotherapy were drawn together and determined the quality control standards for the standardized diagnosis and treatment of gastric cancer.The authors then utilized a modified Delphi approach to generate consensus recommendations.展开更多
We perform a computational simulation of light emissions from two sonoluminescent bubbles in water. Our simulation includes the radii of two bubbles, radiation acoustic pressures, and light emission spectra by numeric...We perform a computational simulation of light emissions from two sonoluminescent bubbles in water. Our simulation includes the radii of two bubbles, radiation acoustic pressures, and light emission spectra by numerically solving the pulsing equations of a two-bubble system and the equations of gas dynamics. The simulation results demonstrate that the motion of each bubble in the two-bubble system is restrained because of the radiation acoustic pressures from the other pulsing bubble. The restrained oscillation of a bubble with a small ambient radius is stronger than that of a bubble with a large ambient radius under the same driving acoustic pressure. This effect increases when the distance between the two bubbles decreases. When compared to single-bubble sonoluminescence, the interaction between two bubbles leads to generation of different spectral characteristics.展开更多
The most recent spectroscopic studies of moving-single bubble sonoluminescence(MSBSL)and multi-bubble sonoluminescence(MBSL)have revealed that hydrated electrons(e^(-)_(aq))are generated in MSBSL but absent in MBSL.To...The most recent spectroscopic studies of moving-single bubble sonoluminescence(MSBSL)and multi-bubble sonoluminescence(MBSL)have revealed that hydrated electrons(e^(-)_(aq))are generated in MSBSL but absent in MBSL.To explore the mechanism of this phenomenon,we numerically simulate the ionization processes in single-and multi-bubble sonoluminescence in aqueous solution of terbium chloride(TbCl_(3)).The results show that the maximum degree of ionization of single-bubble sonoluminescence(SBSL)is approximately 10000 times greater than that of MBSL under certain special physical parameters.The hydrated electrons(e^(-)_(aq))formed in SBSL are far more than those in MBSL provided these electrons are ejected from a bubble into a liquid.Therefore,the quenching of e^(-)_(aq)to SBSL spectrum is stronger than that of the MBSL spectrum.This may be the reason that the trivalent terbium[Tb(Ⅲ)]ion line intensities from SBSL in the TbCl_(3) aqueous solutions with the acceptor of e^(-)_(aq)are stronger than those of TbCl_(3) aqueous solutions without the acceptor of e^(-)_(aq).Whereas the Tb(Ⅲ)ion line intensities from MBSL are not variational,which is significant for exploring the mechanism behind the cavitation and sonoluminescence.展开更多
Molecular imaging(MI)is a novel imaging discipline that has been continuously developed in recent years.It combines biochemistry,multimodal imaging,biomathematics,bioinformatics,cell&molecular physiology,biophysic...Molecular imaging(MI)is a novel imaging discipline that has been continuously developed in recent years.It combines biochemistry,multimodal imaging,biomathematics,bioinformatics,cell&molecular physiology,biophysics,and pharmacology,and it provides a new technology platform for the early diagnosis and quantitative analysis of diseases,treatment monitoring and evaluation,and the development of comprehensive physiology.Fluorescence Molecular Tomography(FMT)is a type of optical imaging modality in MI that captures the three-dimensional distribution of fluorescence within a biological tissue generated by a specific molecule of fluorescent material within a biological tissue.Compared with other optical molecular imaging methods,FMT has the characteristics of high sensitivity,low cost,and safety and reliability.It has become the research frontier and research hotspot of optical molecular imaging technology.This paper took an overview of the recent methodology advances in FMT,mainly focused on the photon propagation model of FMT based on the radiative transfer equation(RTE),and the reconstruction problem solution consist of forward problem and inverse problem.We introduce the detailed technologies utilized in reconstruction of FMT.Finally,the challenges in FMT were discussed.This survey aims at summarizing current research hotspots in methodology of FMT,fromwhich future research may benefit.展开更多
基金Supported by Natural Scienee Foundation of Hainan Province(No 30855)
文摘Objective:To investigate the role of Runx3 protein and TGF-β<sub>1</sub> in the pathogenesis of irritable bowel syndrome（IBS）,as well as the correlation of these two proteins.Methods:Colonic tissue was collected from patients with IBS and normal persons.The colonic expression of Runx3 protein and TGF-β<sub>1</sub> was detected with immunohislochemistry method.Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.Results:Compared with their counterparts,patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β<sub>1</sub>（P】0.05）.Interestingly,there was a significant correlation between Runx3 protein and TGF-β<sub>1</sub> in patients with IBS（P【0.05）.Conclusions:The role of Runx3 protein and TGF-β<sub>1</sub> in the pathogenesis of IBS remains to be further studied.
基金supported by“Beijing Municipal Administration of Hospitals Incubating Program”(No.PX2018043)。
文摘Gastric cancer is one of the most common malignancies of the digestive system,and the number of deaths continues to increase.The standardized management of the diagnosis and treatment of gastric cancer is challenging due to the great differences in the diagnosis and treatment of gastric cancer in different regions.The Gastric Cancer Expert Committee of the National Cancer Quality Control Center(NCQCC)identified a lack of authoritative quality control standards as an opportunity to utilize its multidisciplinary membership to improve the standardized diagnosis and treatment of gastric cancer.The Gastric Cancer Expert Committee of the NCQCC aims to promote quality control and national standardization,uniformity,and normalization of gastric cancer diagnosis and treatment,which ultimately improved the survival rate and quality of life of gastric cancer patients.A panel of experts with gastrointestinal cancer surgery,gastrointestinal cancer medicine,medical imaging,pathology and radiotherapy were drawn together and determined the quality control standards for the standardized diagnosis and treatment of gastric cancer.The authors then utilized a modified Delphi approach to generate consensus recommendations.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11864007 and 11564006)the Science and Technology Planning Project of Guizhou Province of China(Grant No.[2018]5769).
文摘We perform a computational simulation of light emissions from two sonoluminescent bubbles in water. Our simulation includes the radii of two bubbles, radiation acoustic pressures, and light emission spectra by numerically solving the pulsing equations of a two-bubble system and the equations of gas dynamics. The simulation results demonstrate that the motion of each bubble in the two-bubble system is restrained because of the radiation acoustic pressures from the other pulsing bubble. The restrained oscillation of a bubble with a small ambient radius is stronger than that of a bubble with a large ambient radius under the same driving acoustic pressure. This effect increases when the distance between the two bubbles decreases. When compared to single-bubble sonoluminescence, the interaction between two bubbles leads to generation of different spectral characteristics.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11864007 and 11564006)。
文摘The most recent spectroscopic studies of moving-single bubble sonoluminescence(MSBSL)and multi-bubble sonoluminescence(MBSL)have revealed that hydrated electrons(e^(-)_(aq))are generated in MSBSL but absent in MBSL.To explore the mechanism of this phenomenon,we numerically simulate the ionization processes in single-and multi-bubble sonoluminescence in aqueous solution of terbium chloride(TbCl_(3)).The results show that the maximum degree of ionization of single-bubble sonoluminescence(SBSL)is approximately 10000 times greater than that of MBSL under certain special physical parameters.The hydrated electrons(e^(-)_(aq))formed in SBSL are far more than those in MBSL provided these electrons are ejected from a bubble into a liquid.Therefore,the quenching of e^(-)_(aq)to SBSL spectrum is stronger than that of the MBSL spectrum.This may be the reason that the trivalent terbium[Tb(Ⅲ)]ion line intensities from SBSL in the TbCl_(3) aqueous solutions with the acceptor of e^(-)_(aq)are stronger than those of TbCl_(3) aqueous solutions without the acceptor of e^(-)_(aq).Whereas the Tb(Ⅲ)ion line intensities from MBSL are not variational,which is significant for exploring the mechanism behind the cavitation and sonoluminescence.
基金supported by Ministry of Science and Technology of China under Grant No.2017YFA0205200,2016YFC0103702National Natural Science Foundation of China under Grant No.81227901,81527805‘Chinese Academy of Sciences under Grant No.GJJSTD20170004’Beijing Municipal Science&Technology Commission No.Z161100002616022by the General Financial Grant from the China Postdoctoral Science Foundation under Grant 2017 M620952.
文摘Molecular imaging(MI)is a novel imaging discipline that has been continuously developed in recent years.It combines biochemistry,multimodal imaging,biomathematics,bioinformatics,cell&molecular physiology,biophysics,and pharmacology,and it provides a new technology platform for the early diagnosis and quantitative analysis of diseases,treatment monitoring and evaluation,and the development of comprehensive physiology.Fluorescence Molecular Tomography(FMT)is a type of optical imaging modality in MI that captures the three-dimensional distribution of fluorescence within a biological tissue generated by a specific molecule of fluorescent material within a biological tissue.Compared with other optical molecular imaging methods,FMT has the characteristics of high sensitivity,low cost,and safety and reliability.It has become the research frontier and research hotspot of optical molecular imaging technology.This paper took an overview of the recent methodology advances in FMT,mainly focused on the photon propagation model of FMT based on the radiative transfer equation(RTE),and the reconstruction problem solution consist of forward problem and inverse problem.We introduce the detailed technologies utilized in reconstruction of FMT.Finally,the challenges in FMT were discussed.This survey aims at summarizing current research hotspots in methodology of FMT,fromwhich future research may benefit.
