非酒精性脂肪性肝炎的诊治进展

非酒精性脂肪性肝炎(NASH)是晚期肝病的重要病因,其较高的发病率和严重的并发症给社会带来巨大的负担。肝脏活体组织病理检查是诊断NASH的金标准,目前尚无有效的无创性检查可对NASH进行诊断和评估。已有多种评分系统和超声检查技术应用于临床,对肝纤维化的评估有较高的价值。纠正不良生活方式是治疗NASH的重要措施,此外,近年来已有多种新的药物或治疗方法在临床试验中获得了良好的效果。该文就NASH诊断和治疗的研究进展作一综述。

Immunometabolism:A novel perspective of liver cancer microenvironment and its influence on tumor progression

The initiation and progression of liver cancer, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, are dependent on its tumor microenvironment. Immune cells are key players in the liver cancer microenvironment and show complicated crosstalk with cancer cells. Emerging evidence has shown that the functions of immune cells are closely related to cell metabolism. However, the effects of metabolic changes of immune cells on liver cancer progression are largely undefined. In this review, we summarize the recent findings of immunometabolism and relate these findings to liver cancer progression. We also explore the translation of the understanding of immunometabolism for clinical use.

Intratumoral heterogeneity of hepatocellular carcinoma: From singlecell to population-based studies

Hepatocellular carcinoma(HCC)is characterized by high heterogeneity in both intratumoral and interpatient manners.While interpatient heterogeneity is related to personalized therapy,intratumoral heterogeneity(ITH)largely influences the efficacy of therapies in individuals.ITH contributes to tumor growth,metastasis,recurrence,and drug resistance and consequently limits the prognosis of patients with HCC.There is an urgent need to understand the causes,characteristics,and consequences of tumor heterogeneity in HCC for the purposes of guiding clinical practice and improving survival.Here,we summarize the studies and technologies that describe ITH in HCC to gain insight into the origin and evolutionary process of heterogeneity.In parallel,evidence is collected to delineate the dynamic relationship between ITH and the tumor ecosystem.We suggest that conducting comprehensive studies of ITH using single-cell approaches in temporal and spatial dimensions,combined with population-based clinical trials,will help to clarify the clinical implications of ITH,develop novel intervention strategies,and improve patient prognosis.

Effect of auricular plaster for primary hypertension in older people:A meta-analysis

BACKGROUND Hypertension is a critical public health problem globally.Antihypertensive drugs can create an extra burden on hypertension patients'self-regulation leading to an imbalance of blood supply and demand.This study aimed to evaluate the effect of auricular plaster therapy combined with western medicine to treat primary hypertension in older people.AIM To carry out a systematic review and meta-analysis for the effect of auricular plaster in elderly hypertension patients.METHODS Multiple databases like PubMed,EMBASE,Cochrane Library,Chinese Biomedical Literature on Disc,China National Knowledge Infrastructure,Wan Fang and Chinese Science and Technology Periodical Database were used to search for the relevant studies and full-text articles involved in the evaluation of auricular plaster combined with western medicine and western medicine alone for primary hypertension in older people.All included articles were quality assessed and the data analysis was conducted with the Review Manager(5.4).Forest plots,sensitivity analysis and funnel plots were also performed on the included articles.RESULTS In this analysis,fourteen(14)relevant studies were included.The Meta-analysis showed a significant difference in the effective ratio(OR=3.62;95%CI,2.46 to 5.33;P<0.00001),diastolic blood pressure change(5.68 mmHg;95%CI,3.49 to 7.87;P<0.00001),systolic blood pressure change(MD=8.78 mmHg;95%CI,5.04 to 12.53;P<0.00001)and symptom score(MD=3.20;95%CI,1.23 to 5.18;P=0.001)between auricular plaster combined with western medicine group and western medicine alone group.One bias was detected as selection bias and another two in reporting bias.Sensitivity analysis fulfilled the stability of the results.CONCLUSION Our study suggested that auricular plaster combined with western medicine improved primary hypertension better than western medicine alone.Limited by the quality of included studies,further studies should be performed to confirm our findings.

Medium-range order endows a bulk metallic glass with enhanced tensile ductility

Developing ductile bulk metallic glasses(BMGs)can benefit from an in-depth understanding of the structure-property relation during plastic deformation.However,endowing BMGs with tensile ductility in BMGs needs to reveal the response of critical structure units during deformation.Here,we report the experimental results of an in-situ synchrotron high-energy X-ray study of a Zr-based BMG under uniaxial tension after preprocessing by canning compression of the three-dimensional compressive stress state.It is revealed that the canning-compressed BMG(CC-BMG)sample has better tensile ductility and higher ultimate strength than the as-cast sample,which possesses heterogeneous and loosely packed local struc-tures on medium-range scales.The experimental results revealed two stages of plastic deformation in the CC-BMGs compared with one stage of plastic deformation in the as-cast BMG.Moreover,the shift in the first sharp diffraction peak along the tension direction for the canning-compressed sample is substan-tially more pronounced than that of the as-cast sample.Furthermore,the real-space analysis illustrates a competition mechanism between the 2-atom and 3-atom connection modes on medium-range order during the plastic deformation of the CC-BMG.Additionally,the ordering on the medium-range scale de-creases in the first plastic deformation stage but increases in the second plastic deformation stage.There-fore,a structural crossover phenomenon occurs in the CC-BMG during plastic deformation.Our results demonstrate a structure-property correlation for the CC-BMGs of heterogeneous medium-range ordered structures,which may be beneficial for endowing BMGs with ductility based on medium-range order engineering techniques.

Quorum sensing systems regulate heterotrophic nitrification-aerobic denitrification by changing the activity of nitrogen-cycling enzymes

Heterotrophic nitrification-aerobic denitrification(HNAD)is essential in diverse nitrogen-transforming processes.How HNAD is modulated by quorum sensing(QS)systems is still ambiguous.The QS system in Pseudomonas aeruginosa manipulates colony behavior.Here,we described the influence of the Pseudomonas quinolone signal(PQS)and N-acyl-L-homoserine lactone(AHL)on HNAD.The HNAD of P.aeruginosa was inhibited by the oversecretion of PQS.AHL-or PQS-deficient P.aeruginosa mutants had a higher ability for nitrogen removal.QS inhibited heterotrophic nitrification mainly via controlling the activity of nitrite oxidoreductase(NXR)and the depressed aerobic denitrification by regulating the catalytic abilities of nitric oxide reductase(NOR),nitrite reductase(NIR),and nitrate reductase(NAR).The addition of citrate as the sole carbon source increased the nitrogen removal efficiency compared with other carbon sources.Nitrite,as the sole nitrogen source,could be used entirely with only the moderate concentration of PQS contained.AHL and PQS controlled both nitrification and denitrification,suggesting that QS plays an important role in nitrogen cycle under aerobic conditions.

Exact solutions of the nonlocal Gerdjikov-Ivanov equation

The nonlocal nonlinear Gerdjikov-Ivanov(GI)equation is one of the most important integrable equations,which can be reduced from the third generic deformation of the derivative nonlinear Schr?dinger equation.The Darboux transformation is a successful method in solving many nonlocal equations with the help of symbolic computation.As applications,we obtain the bright-dark soliton,breather,rogue wave,kink,W-shaped soliton and periodic solutions of the nonlocal GI equation by constructing its 2 n-fold Darboux transformation.These solutions show rich wave structures for selections of different parameters.In all these instances we practically show that these solutions have different properties than the ones for local case.