A layered multifunctional framework based on polyacrylonitrile and MOF derivatives for stable lithium metal anode

Composite Li metal anodes based on three-dimensional(3D) porous frameworks have been considered as an effective material for achieving stable Li metal batteries with high energy density.However,uneven Li deposition behavior still occurs at the top of 3D frameworks owing to the local accumulation of Li ions.To promote uniform Li deposition without top dendrite growth,herein,a layered multifunctional framework based on oxidation-treated polyacrylonitrile(OPAN) and metal-organic framework(MOF) derivatives was proposed for rationally regulating the distribution of Li ions flux,nucleation sites,and electrical conductivity.Profiting from these merits,the OPAN/carbon nano fiber-MOF(CMOF) composite framework demonstrated a reversible Li plating/stripping behavior for 500 cycles with a stable Coulombic efficiency of around 99.0% at the current density of 2 mA/cm~2.Besides,such a Li composite anode exhibited a superior cycle lifespan of over 1300 h under a low polarized voltage of 18 mV in symmetrical cells.When the Li composite anode was paired with LiFePO_(4)(LFP) cathode,the obtained full cell exhibited a stable cycling over 500 cycles.Moreover,the COMSOL Multiphysics simulation was conducted to reveal the effects on homogeneous Li ions distribution derived from the above-mentioned OPAN/CMOF framework and electrical insulation/conduction design.These electrochemical and simulated results shed light on the difficulties of designing stable and safe Li metal anode via optimizing the 3D frameworks.

TWO NEW OLEANOLIC ACID SAPONINS FROM ASTER YUNNANENSIS

Two new oleanolic acid saponins named asteryunnanoside F and G were isolated from the roots. of Aster yunnenensis. The chemical structures were determined as oleanolic acid-28-O-βD-glucopyranosyl-(1→6)-β-D-glucO and 3-O-β-Dglucopyranosyl-oleanolic acid-28-O-βD-glucopyranosyl-(1→6)[-rhamn by speCtral data,especially 2D NMR anajysis (COSY, HETCOR, HOHAHA and ROESY), and Chemical transformations.

ASTERYUNNANOSIDE A AND B，TWO NEW TRITERPENOID SAPONINS FROM ASTER YUNNANENSIS FRANCH

Two new oleanane-type triterpenoid saponins.sateryunn3noside A and B,were isolated from the roots of Aster yunnanensis Franch,and their Structures were elucidated based on spectral evidence and chemical hydrolysis. They have the same aglycone,Which has been assigned as 2a,3 .23-trihydroxyolean-12-en-28-cio acid,and the deference consisted only in 28-O-linked sugar moieties. Asteryunnanoside A is a 28-O-a-L-rhamnopyranosyl-(1-2)- -D-glucopyranoside and B is 28-O- -D-glucopyranosyl-(1 -2),-D-glucopyranoside of the corresponding aglycone.

ASTERYUNNANOSIDE E,A NEW TRITERPENOID SAPONIN FROM ASTER YUNNANENSIS FRANCH

A new oleanane-type triterpene saponin. asteryunnanoside E. has been isolated from the roots of Astir yunnanensis Franch. and its structure elucidated as 3-O-β-D-glucopyranosyl-bayogenin-28-O-β-glucopyranoside by means of spectral data particularly 2D NMR including COSY. HETCOR, HOHAHA and ROESY techniques and chemical transformation.

Analysis of fluidized zone in transparent soil under jet induced by pipe leakage

Jets caused by burst tubes erode the surrounding soil, eventually leading to issues such as ground collapse. It is therefore highly important to study the mechanisms of soil erosion caused by jets after pipeline leakage. To investigate the water-soil interaction mechanisms of pipe leakage, this study used transparent soil and developed a three-dimensional experimental device to observe the fluidization process. Changes in the boundary of the fluidization transition area were investigated, and a formula for calculating the soil damage area was derived. The results showed three different shapes of the fluidized cavity appearing in the fluidization process. The particles initially moved upward and then gradually transitioned into a state of backflow. The effects of particle size, upper load, and porosity on fluidization were also analyzed. It was found that soil with a large particle size and a lower porosity under a heavy upper load can effectively restrain fluidization. Therefore, large-diameter and dense soil can be used as pipe-covering material.

不同清洗方式对义齿白色假丝酵母菌生物膜清除效果的影响

目的比较不同清洁方式对义齿白色假丝酵母菌生物膜的清除能力。方法制作并消毒树脂片,在其表面培养白色假丝酵母菌生物膜,分别以化学(浸泡)、机械(刷洗)和复合(浸泡与刷洗并用)等方式处理覆有白色假丝酵母菌生物膜的树脂片,再将其浸入新鲜培养液进行残留生物膜的恢复培养,分别在0、6、24h后利用菌落计数进行效果评价。结果机械清除效果与牙膏种类密切相关,单纯的化学处理没有明显的清除作用,保丽净义齿清洁片复合处理清除白色假丝酵母菌生物膜的效果最佳,其处理后的树脂片培养24h仍未检出白色假丝酵母菌。结论不同的义齿清洗方法对附着在义齿表面的白色假丝酵母菌生物膜的清除能力有差异。其中,以保丽净义齿清洁片复合效果最好且能够持续地发挥抑菌作用。

高效义齿清洁剂去除菌斑染色的体外实验研究

目的:以食物色素染色模型为基础,对一种新型浸泡式义齿清洁剂去除染色的效果进行量化评估。方法:为了便于形成均一的菌斑生长表面及后期的染色测量,本研究采用聚甲基丙烯酸甲酯树脂片片来模拟义齿表面。树脂片经过消毒灭菌后浸泡于ToddHewitt肉汤培养基和人工唾液中培养18h(37℃)。处理后的树脂片取出晾干后被分为实验组和对照组,均置于咖啡、茶、蓝莓酱和红酒混合液中染色18h。使用分光光谱仪(PR650)定量测量染色前树脂片的颜色。染色后的实验组和对照组树脂片分别用义齿清洁泡腾片(Polident)和蒸馏水中浸泡5min(150mL水,40℃)。最后再次使用PR650测量树脂片颜色参数,并计算试样间色差。结果:配对t检验显示实验组和对照组的L*,a*,b*3个颜色参数以及总色差ΔE之间存在显著性差异(P<0.001)。义齿清洁泡腾片(Polident)显著地清除了色素。结论:义齿泡腾片(Polident)能清除由红酒、茶等色素引起的义齿表面着色。

视疲劳调查量表在调节性视疲劳患者中的应用

目的:应用视疲劳调查量表调查调节性视疲劳患者的视疲劳情况及治疗前后评分差异,评价其在该人群中的信度、效度及反应度。方法:对112例上海中医药大学附属曙光医院眼科就诊及线上招募的调节性视疲劳患者,使用视疲劳调查量表进行调查,再随机抽取48例调查对象于1wk后重测,采用多种信度、效度及反应度指标对量表进行评价。结果:量表条目的总体Cronbach’sα系数为0.91;分半信度系数为0.86;量表总分的重复测量相关系数为0.74,前后无差异(P>0.05);验证性因子分析结果表明三因子结构模型绝对拟合指数χ^(2)/df<2.0,RMSEA=0.08;相关分析中各维度总分和量表总分的相关系数分别为0.92、0.90、0.83;标准关联效度分析显示组间有差异(P<0.01)。反应度分析显示治疗前后有差异(P<0.01)。结论:ASS量表用于调节性视疲劳的临床评价具有较高的信度、效度及反应度,是视疲劳人群临床研究或筛检的有效工具。

海藻酸钠-g-聚丙烯酰胺/氧化石墨烯复合水凝胶的制备及控释行为

以海藻酸、丙烯酰胺为单体,氧化石墨烯为原料制备了海藻酸钠-g-聚丙烯酰胺/氧化石墨烯(NaAlg-g-PAAm/GO)复合水凝胶,采用傅里叶变换红外光谱和扫描电镜对其结构和形貌进行了表征;当GO的质量分数从0.6%增至3.2%时,溶胀率从37%减至21%;阳离子对水凝胶的溶胀性的影响能力是Fe3+>Ca2+>K+;以5-氟尿嘧啶(5-FU)为抗癌药物模型,模拟胃腔和小肠的环境,研究了在pH=1.2和pH=7.4的缓冲溶液中复合水凝胶的控制释放行为,实验结果表明水凝胶在pH=7.4的缓冲溶液中的累积释放率明显高于在pH=1.2的溶液中的累积释放率,所以该类水凝胶有望成为靶向药物释放的载体。

Mn3O4包覆对LiNi0.5Mn1.5O4正极材料界面电化学性能的提高

本文采用化学湿磨法,首次将金属氧化物Mn3O4包覆于LiNi(0.5)Mn(1.5)O4颗粒表面,使得电极材料的电子电导率从1.53×10^-7S/cm提高到3.15×10^-5S/cm.电化学测试结果表明Mn3O4包覆大大提高LiNi(0.5)Mn(1.5)O4正极材料的倍率性能和高温循环稳定性.最佳包覆样品为2.6wt%Mn3O4包覆的LiNi(0.5)Mn(1.5)O4,在10 C倍率下具有108 mAh/g的高放电容并且在55℃下100次循环后仍有78%的容量保持率,远大于未包覆样品67%的容量保持率.

Hot deformation behaviors of a 9Cr oxide dispersion-strengthened steel and its microstructure characterization

The hot deformation behaviors of a 9 Cr oxide dispersion-strengthened(9 Cr-ODS) steel fabricated by mechanical alloying and hot isostatic pressing(HIP) were investigated. Hot compression deformation experiments were conducted on a Gleeble 3500 simulator in a temperature range of 950–1100°C and strain rate range of 0.001–1 s^(-1). The constitutive equation that can accurately describe the relationship between the rheological stress and the strain rate of the 9 Cr-ODS steel was established, and the deformation activation energy was calculated as 780.817 kJ/mol according to the data obtained. The processing maps of 9 Cr-ODS in the strain range of 0.1–0.6 were also developed. The results show that the region with high power dissipation efficiency corresponds to a completely recrystallized structure. The optimal processing conditions were determined as a temperature range of 1000–1050°C with strain rate between 0.003 and 0.01 s^(-1).

高性能的钛掺杂O3相Na1-xCr1-xTixO2（x=0,003,005）用于钠离子电池正极材料的研究（英文）

本文通过凝胶热聚合路线合成了层状的03相正极材料Na1—xCr1—xTixO2(x=0,0.03,0.05),采用X射线衍射、扫描电子显微镜来分析其晶体结构和微观形貌.研究发现,适量的钛掺杂有助于形成更均匀的颗粒并且会改变样品的颜色.作为钠离子电池正极材料,Na//Na0.97Cr0.97Ti0.03O2具有非常高的库伦效率(首次高于96%),并且在2.0-3.6V的电化学窗口下,用0.2C的倍率循环100次,只有4%的容量衰减;在32C倍率下有110mAh/g的比容量.

Synthesis and Characterization of Novel Polyimides Based on Pyridine-containing Diamine

A new aromatic diamine monomer containing pyridine unit, 2,6-bis （4-aminophenoxy- 4＇-benzoyl）pyridine（BABP）, was synthesized in three steps, starting from 2,6-pyridinedicarboxyl chloride. A series of novel pyridine-containing polyimides were prepared v/a the polycondensation of BABP with various aromatic dianhydrides through poly（amic acid） precursors, and thermal or chemical imidization of the precursors. The polyimides exhibit desirable properties, e.g., good solubility in N-methyl-2-pyrrolidone and m-cresol, excellent thermal stability and film-forming capability, as well as high inherent viscosity, indicating high molecular weight.

STRUCTURAL ELUCIDATION AND SYNTHESIS OF ASTERBATANOSIDE A FROM ASTER BATANFENSIS

A new p-acetylphenyl glycoside,asterbatanoside A has been isolated from the roots of Aster batangensis, and its structure has been elucidated as p-hydroxyacetophenone- -O-α-D-xylopyranosyl-(1,6) -β-D-glucopyranoside by chemical and spectral means.For the confirmation of this structure. the synthesis of this compound was also reported in this paper.

Down-regulation of N-methyl-D-aspartate receptor subunits 1 affects neurogenesis of hippocampal neural stem cells

Schizophrenia is a common and serious mental illness characterized by severe impairments in thinking,emotions,and behaviors.Usually,the cognitive deficits of schizophrenia are closely associated with abnormal neurogenesis due to the hypofunction of certain neural receptors such as N-methyl-D-aspartate receptors(NMDARs),which mediates neurotransmission.However,little is known about the involvement of NMDAR1 in regulating hippocampal neurogenesis in schizophrenia.In the current study,we present evidence suggesting that NMDAR1 regulates hippocampal neurogenesis as lentivirus-mediated shRNA silencing NMDAR1 gene or blocking with MK-801 results in abnormal neurogenesis consistently found in schizophrenia.The important finding was clearly demonstrated by the multiparametric assessments,including morphology,immunofluorescence,western blotting,and flow cytometry.Simultaneously,our results indicated that knockdown and blockade of NMDAR1 significantly attenuated the proliferation of hippocampal neural stem cells(hNSCs)and decreased the differentiation to neurons.More importantly,the blockade of NMDAR1 with MK-801 aggravated the apoptosis of hNSCs.Thus,it is likely that NMDAR1 functions as a new target for the treatment of schizophrenia.Our present study may provide a novel insight for further investigation of the pathogenesis of schizophrenia.

PD-1 inhibitor in combination with fruquintinib therapy for initial unresectable colorectal cancer:A case report

BACKGROUND PD-1 inhibitors in combination with fruquintinib have not previously been reported as neoadjuvant therapy for patients with colorectal cancer.In this case report,the combination of a PD-1 inhibitor and fruquintinib demonstrated good efficacy in patients with MSI-H colorectal cancer.CASE SUMMARY The patient was a young man in his 30s who had MSI-H type colon cancer.The patient underwent four cycles of neoadjuvant therapy with a PD-1 inhibitor combined with fruquintinib before surgery,resulting in regression of the mass and a successful surgery.CONCLUSION Some patients with colorectal cancer have the MSI-H type,and the first-line chemotherapy regimen is not effective.However,PD-1 monoclonal antibody immunotherapy has a good therapeutic effect,which can be improved by combination therapy with fruquintinib.We recommend that patients with a history of colon or rectal cancer receive universal MSI testing;then,neoadjuvant therapy should be used.

INULOSIDE A AND B． TWO NEW DITERPENE GLYCOSIDES FROM INULA BRITANNICAL． VAR CHINENSIS

Two new diterpene glycosides, inulosides A and B, have been isolated from Inula britsnnica L. var chinensis and their structures established as (-)-17-O-β-D-glucopyranosyl-16α-kauran-19-oic acid and (-)-17-O-β-D-glucopyran-osyl-l6α-kauran-19-cio acid-19-O-β-D-glucopyranoside, respectively. through spectral data. and chemical and enzymatical methods.

OLIGOPEPTIDES FROM THE ROOTS OF ASTER TATARICUS L. f.

Two new oligopeptides, Asterin A and B, have been isolated from the roots of Aster tataricus L. f., and their structures were elucidated on the basis of spectroscop- ic, chemical and enzymatic methods.

Active Template Synthesis of Protein[n]Catenanes Using Engineered Peptide–Peptide Ligation Tools

The expansion of protein topological diversity requires new and efficient synthetic tools.Herein,we report the second and third generations of the SpyStapler-mediated SpyTag/BDTag ligation system for the efficient synthesis of 4-arm star proteins and the repurposing of the third generation as an active template to enable the synthesis of higher-order protein[n]catenanes(n=3,4,and 5).SpyStapler003 has a higher affinity to its cognate SpyTag and BDTag reactive pairs relative to the original SpyStapler.Hence,it can overcome much more profound steric hindrance in protein ligation and improve the efficiency of the resulting active template tool to facilitate the construction of radial protein[n]catenanes.Various proteins of interest,such as dihydrofolate reductase and the nanobody KN035,can be modularly incorporated into the[n]catenanes with intact activity.Combination of passive and active template strategies gives rise to linear protein[4]catenanes,which further expands the current topological diversity.Moreover,higher-order protein catenation not only leads to enhanced thermal stability and proteolytic resistance but also higher affinity of the nanobody via multivalent effects.Our study provides tools useful for bioconjugation and new topological protein scaffolds for the multivalent display of enzymes and antibodies.

Unconventional 2D Periodic Nanopatterns Based on Block Molecules

This review summarizes the self-assembly of block molecules forming unconventional two-dimensional(2D)periodic nanopatterns.Especially,we emphasize the structural evolution from simple columnar phases to complex 2D tiling morphologies in soft materials including block copolymers,liquid crystals,giant molecules,etc.Then,the state-of-the-art nanofabrication technologies for making sophisticated nanostructures with specific functions via combining both bottom-up assembly and top-down lithography-based methods are discussed,highlighting the use of directed self-assembly processes.Finally,we provide our perspective on this area.By further increasing the complexity of block molecules and the designability of lithography,low-dimensional ordered morphologies will be particularly promising for further application in nanotechnology.