Experiments were conducted to evaluate the healing of drying cracks in air-dried bentonite-sand blocks after hydration and swelling in groundwater,providing justifications to simplify the protection of blocks prior to...Experiments were conducted to evaluate the healing of drying cracks in air-dried bentonite-sand blocks after hydration and swelling in groundwater,providing justifications to simplify the protection of blocks prior to installation in a high-level radioactive waste repository.Synthetic groundwater was prepared to represent the geochemistry of Beishan groundwater,and was used to hydrate the blocks during the swelling pressure and swelling strain measurements,as Beishan is the most promising site for China's repository.Healing of the surface cracks was recorded by photography,and healing of the internal cracks was visualized by CT images and hydraulic conductivity of air-dried blocks.The results indicate that the maximum swelling pressure and swelling strain are primarily affected by the geochemistry of Beishan groundwater,but not affected by the drying cracks.The maximum swelling pressure and swelling strain of air-dried blocks are comparable to or even higher than the pressure and strain of fresh blocks.The maximum swelling pressure measured in strong(i.e.high ion strength)Beishan groundwater was 44%of the pressure measured in deionized(DI)water,and the maximum swelling strain was reduced to 23%of the strain measured in DI water.Nevertheless,the remained swelling of the blocks hydrated in strong Beishan groundwater was sufficient to heal the surface and internal drying cracks,as demonstrated by the pictures of surface cracks and CT images.The hydraulic conductivity of the air-dried block permeated with strong groundwater was comparable(3.7×higher)to the hydraulic conductivity of the fresh block,indicating the self-healing of drying cracks after hydration and swelling in groundwater.A simplified method of protecting the block with plastic wraps before installation is recommended,since the remained swelling of the block hydrated in Beishan groundwater is sufficient to heal the drying cracks.展开更多
Failure analyses of piezoelectric structures and devices are of engineering and scientific significance.In this paper,a fourth-order phase-field fracture model for piezoelectric solids is developed based on the Hamilt...Failure analyses of piezoelectric structures and devices are of engineering and scientific significance.In this paper,a fourth-order phase-field fracture model for piezoelectric solids is developed based on the Hamilton principle.Three typical electric boundary conditions are involved in the present model to characterize the fracture behaviors in various physical situations.A staggered algorithm is used to simulate the crack propagation.The polynomial splines over hierarchical T-meshes(PHT-splines)are adopted as the basis function,which owns the C1continuity.Systematic numerical simulations are performed to study the influence of the electric boundary conditions and the applied electric field on the fracture behaviors of piezoelectric materials.The electric boundary conditions may influence crack paths and fracture loads significantly.The present research may be helpful for the reliability evaluation of the piezoelectric structure in the future applications.展开更多
The global distributions of the air-sea CO2 transfer velocity and flux are retrieved from TOPEX/Poseidon and Jason altimeter data from October 1992 to December 2009 using a combined algorithm. The 17 a average global,...The global distributions of the air-sea CO2 transfer velocity and flux are retrieved from TOPEX/Poseidon and Jason altimeter data from October 1992 to December 2009 using a combined algorithm. The 17 a average global, area-weighted, Schmidt number-corrected mean gas transfer velocity is 21.26 cm/h, and the full exploration of the uncertainty of this estimate awaits further data. The average total CO2 flux （calculated by carbon） from atmosphere to ocean during the 17 a was 2.58 Pg/a. The highest transfer velocity is in the circumpolar current area, because of constant high wind speeds and currents there. This results in strong CO2 fluxes. CO2 fluxes are strong but opposite direction in the equatorial east Pacific Ocean, because the air-sea CO2 partial pressure difference is the largest in the global cceans. The results differ from the previous studies calculated using the wind speed. It is demonstrated that the air-sea transfer velocity is very important for estimating air-sea CO2 flux. It is critical to have an accurate estimation for improving calculation of CO2 flux within climate change studies.展开更多
Using data from the European remote sensing scatterometer （ERS-2） from July 1997 to August 1998, glob- al distributions of the air-sea CO2 transfer velocity and flux are retrieved. A new model of the air-sea CO2 tra...Using data from the European remote sensing scatterometer （ERS-2） from July 1997 to August 1998, glob- al distributions of the air-sea CO2 transfer velocity and flux are retrieved. A new model of the air-sea CO2 transfer velocity with surface wind speed and wave steepness is proposed. The wave steepness （6） is re- trieved using a neural network （NN） model from ERS-2 scatterometer data, while the wind speed is directly derived by the ERS-2 scatterometer. The new model agrees well with the formulations based on the wind speed and the variation in the wind speed dependent relationships presented in many previous studies can be explained by this proposed relation with variation in wave steepness effect. Seasonally global maps of gas transfer velocity and flux are shown on the basis of the new model and the seasonal variations of the transfer velocity and flux during the 1 a period. The global mean gas transfer velocity is 30 cm/h after area-weighting and Schmidt number correction and its accuracy remains calculation with in situ data. The highest transfer velocity occurs around 60°N and 60°S, while the lowest on the equator. The total air to sea CO2 flux （calcu- lated by carbon） in that year is 1.77 Pg. The strongest source of CO2 is in the equatorial east Pacific Ocean, while the strongest sink is in the 68°N. Full exploration of the uncertainty of this estimate awaits further data. An effectual method is provided to calculate the effect of waves on the determination of air-sea CO2 transfer velociW and fluxes with ERS-2 scatterometer data.展开更多
The numerous factors influencing the air-sea carbon dioxide（CO_2） transfer velocity have been discussed for many years, yet the contributions of various factors have undergone little quantitative estimation. To bett...The numerous factors influencing the air-sea carbon dioxide（CO_2） transfer velocity have been discussed for many years, yet the contributions of various factors have undergone little quantitative estimation. To better understand the mechanism of air-sea transfer, the effects of different factors are discussed on the air-sea transfer velocity and the various parametric models describing the phenomenon are classified and compared.Then, based on GAS EX-98 and ASGAMAGE data, wind models are evaluated and the effects of some factors are discussed quantitatively, including bubbles, waves, wind and so on by considering their interaction through a piecewise average approach. It is found that the air-sea CO_2 transfer velocity is not only the function of the wind speed, but is also affected by bubbles, wave parameters and other factors. Stepwise and linear regressions are used. When considering the wind speed, bubbles mediated and the significant wave height, the root mean square error is reduced from 34.53 cm/h to 16.96 cm/h. Discussing the various factors quantitatively can be useful in future assessments of a large spatial scale and long-term air-sea CO_2 flux and global change.展开更多
An improved moving least square meshless method is developed for the numerical solution of the nonlinear improved Boussinesq equation. After the approximation of temporal derivatives, nonlinear systems of discrete alg...An improved moving least square meshless method is developed for the numerical solution of the nonlinear improved Boussinesq equation. After the approximation of temporal derivatives, nonlinear systems of discrete algebraic equations are established and are solved by an iterative algorithm. Convergence of the iterative algorithm is discussed. Shifted and scaled basis functions are incorporated into the method to guarantee convergence and stability of numerical results. Numerical examples are presented to demonstrate the high convergence rate and high computational accuracy of the method.展开更多
The emerging rocking-chair aqueous zinc-ion battery(AZIB)configuration provides a promising approach for realizing their practical applications by avoiding the critical drawbacks of Zn metal anodes including unsatisfa...The emerging rocking-chair aqueous zinc-ion battery(AZIB)configuration provides a promising approach for realizing their practical applications by avoiding the critical drawbacks of Zn metal anodes including unsatisfactory Coulombic efficiency and low Zn utilization.Therefore,exploiting appropriate insertion-type anodes with fast charge-transfer kinetics is of great importance,and many modifications focusing on the improvement of electron transport and bulk Zn^(2+)diffusion have been proposed.However,the interfacial Zn^(2+)transfer determined by the desolvation process actually dominates the kinetics of overall battery reactions,which is mainly overlooked.Herein,the interlayer structure of Mo S_(2)is rationally co-intercalated with water and ethylene glycol(EG)molecules(Mo S2@EG),giving rise to a fast non-desolvation Zn^(2+)storage mechanism,which is verified by the extraordinarily smaller activation energy of interfacial Zn^(2+)transfer(4.66 k J mol^(-1))compared with that of pristine Mo S_(2)(56.78 k J mol^(-1)).Furthermore,the results of theoretical calculations,in-situ Raman and ex-situ characterizations also indicate the enhanced structural integrity of Mo S2@EG during cycling due to the enlarged interlayer spacing and charge screening effect induced by interlaminar EG molecules.Consequently,the Mo S_(2)@EG anode enables excellent cycling stability of both high-energy-density Mo_S2@EG||PVO(polyaniline intercalated V_(2)O_(5))and high-voltage Mo S2@EG||Na_(3)V_(2)(PO_(4))_2O_(2)F(NVPF)full batteries with neglectable capacity decay at-20℃.展开更多
Aqueous zinc-ion batteries(ZIBs) have attracted significant attentions because of low cost and high reliability. However, conventional ZIBs are severely limited by the development of high energy density cathode materi...Aqueous zinc-ion batteries(ZIBs) have attracted significant attentions because of low cost and high reliability. However, conventional ZIBs are severely limited by the development of high energy density cathode materials with reversible Zn^(2+)insertion/extraction. Herein, a conducting polymer intercalated MoO_(3)(PMO) with extensively extended interlayer spacing is developed as a high-performance ZIBs cathode material. The interlayer spacing of PMO is prominently increased which results in an improved Zn^(2+)mobility during charge and discharge process. More significantly, the electrochemical results reveals that the intercalation of PANI facilitates the charge storage and reinforces the layered structure of MoO_(3), leading to a high capacity and good cycling stability. DFT calculation further reveals the intercalation of PANI into MoO_(3)significantly lower Zn^(2+)diffusion barrier. Benefit from these advantages, the ZIBs based on PMO electrode delivers a considerable capacity of 157 m Ah/g at 0.5 A/g and ameliorative stability with 63.4%capacity retention after 1000 cycles.展开更多
The analytical solution of a thermo-poro-elastic medium in static state weakened by a Griffith crack with finite width is presented.By virtue of the Fourier cosine and sine integral transform techniques,the mixed boun...The analytical solution of a thermo-poro-elastic medium in static state weakened by a Griffith crack with finite width is presented.By virtue of the Fourier cosine and sine integral transform techniques,the mixed boundary-value problem is formulated as three pairs of dual integral equations,which are solved with the help of the Abel transform.In addition,the stress intensity factor of mode Ⅰ and the crack surface displacement are presented analytically.Numerical examples are performed to show the distribution of displacement and stress over the thermo-poro-elastic medium.The results indicate that the thermal load will increase or decrease the crack surface displacement,but has a weak influence on the stress intensity factor.The present work may benefit future engineering applications.展开更多
Objective: The aim of this study was to identify the potential pharmacological mechanisms of Gualou-Xiebai-Banxia decoction(GLXBBX) against unstable angina(UA). Materials and Methods: The active compounds of GLXBBX we...Objective: The aim of this study was to identify the potential pharmacological mechanisms of Gualou-Xiebai-Banxia decoction(GLXBBX) against unstable angina(UA). Materials and Methods: The active compounds of GLXBBX were collected from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, and their targets were predicted using the Swiss Target Prediction database. The targets associated with UA were obtained from the Online Mendelian Inheritance in Man, Gene Cards, and Therapeutic Target Database. Individual targets associated with UA and GLXBBX were cross-checked to identify the targets of GLXBBX involved in the treatment of UA. A protein–protein interaction network was built using the STRING online database. Cytoscape 3.7.2 software was used to screen out hub genes. Additional gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed using the cluster Profiler package in R. Results: A total of 28 bioactive compounds and 320 protein targets of GLXBBX associated with UA were screened out. Enrichment analysis indicated that the therapeutic effect of GLXBBX may be mediated through the PI3K/AKT, MAPK, and HIF-1 signaling pathways. Molecular docking suggested that the active compounds including Vitamin E, cavidine, and baicalein can bind to their protein receptors. Conclusions: This research confirmed the multifactorial effects of GLXBBX in the treatment of UA and laid the foundation for the experimental research on GLXBBX.展开更多
Centrifugal granulation is one key step to enable waste heat recovery from the molten slag in the iron and steel industry.Yet,it remains unknown about the granulation characteristics of molten slag with different chem...Centrifugal granulation is one key step to enable waste heat recovery from the molten slag in the iron and steel industry.Yet,it remains unknown about the granulation characteristics of molten slag with different chemical compositions,especially at high throughput.In this work,we provided an experimental study on centrifugal granulation with four types of molten slags.The stage-specific centrifugal granulation was recorded and analyzed at first.Both effects of atomizer configuration and chemical compositions on granulation were investigated in detail.The cup-type atomizer favors film-mode disintegration and possesses better anti-adhesion capacity although the final granule size was not strongly affected by the atomizer configuration.Most importantly,centrifugal granulation has been demonstrated with appreciable adaptability to composition-specific blast furnace(BF)slag with binary basicity of 0.9-1.3.The present study not only sheds light on the modest effect of the chemical composition of molten slag on centrifugal granulation characteristics,but also gains credit for the adaptivity of CGATER.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.41972265)the Fundamental Research Funds for the Central Universities(Grant No.lzujbky-2021-57)+1 种基金the Gansu Province Science Foundation(Grant No.20JR10RA492)Special thanks to the Environmental Research and Education Foundation for supporting the first author(Y.Tan)through a fellowship for his study at the University of Wisconsin-Madison.
文摘Experiments were conducted to evaluate the healing of drying cracks in air-dried bentonite-sand blocks after hydration and swelling in groundwater,providing justifications to simplify the protection of blocks prior to installation in a high-level radioactive waste repository.Synthetic groundwater was prepared to represent the geochemistry of Beishan groundwater,and was used to hydrate the blocks during the swelling pressure and swelling strain measurements,as Beishan is the most promising site for China's repository.Healing of the surface cracks was recorded by photography,and healing of the internal cracks was visualized by CT images and hydraulic conductivity of air-dried blocks.The results indicate that the maximum swelling pressure and swelling strain are primarily affected by the geochemistry of Beishan groundwater,but not affected by the drying cracks.The maximum swelling pressure and swelling strain of air-dried blocks are comparable to or even higher than the pressure and strain of fresh blocks.The maximum swelling pressure measured in strong(i.e.high ion strength)Beishan groundwater was 44%of the pressure measured in deionized(DI)water,and the maximum swelling strain was reduced to 23%of the strain measured in DI water.Nevertheless,the remained swelling of the blocks hydrated in strong Beishan groundwater was sufficient to heal the surface and internal drying cracks,as demonstrated by the pictures of surface cracks and CT images.The hydraulic conductivity of the air-dried block permeated with strong groundwater was comparable(3.7×higher)to the hydraulic conductivity of the fresh block,indicating the self-healing of drying cracks after hydration and swelling in groundwater.A simplified method of protecting the block with plastic wraps before installation is recommended,since the remained swelling of the block hydrated in Beishan groundwater is sufficient to heal the drying cracks.
基金Project supported by the National Natural Science Foundation of China(Nos.12072297 and12202370)the Natural Science Foundation of Sichuan Province of China(No.24NSFSC4777)。
文摘Failure analyses of piezoelectric structures and devices are of engineering and scientific significance.In this paper,a fourth-order phase-field fracture model for piezoelectric solids is developed based on the Hamilton principle.Three typical electric boundary conditions are involved in the present model to characterize the fracture behaviors in various physical situations.A staggered algorithm is used to simulate the crack propagation.The polynomial splines over hierarchical T-meshes(PHT-splines)are adopted as the basis function,which owns the C1continuity.Systematic numerical simulations are performed to study the influence of the electric boundary conditions and the applied electric field on the fracture behaviors of piezoelectric materials.The electric boundary conditions may influence crack paths and fracture loads significantly.The present research may be helpful for the reliability evaluation of the piezoelectric structure in the future applications.
基金The Public Science and Technology Research Funds Projects of Ocean of State Oceanic Administration People’s Republic of China under contract No.200905012a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions of China
文摘The global distributions of the air-sea CO2 transfer velocity and flux are retrieved from TOPEX/Poseidon and Jason altimeter data from October 1992 to December 2009 using a combined algorithm. The 17 a average global, area-weighted, Schmidt number-corrected mean gas transfer velocity is 21.26 cm/h, and the full exploration of the uncertainty of this estimate awaits further data. The average total CO2 flux （calculated by carbon） from atmosphere to ocean during the 17 a was 2.58 Pg/a. The highest transfer velocity is in the circumpolar current area, because of constant high wind speeds and currents there. This results in strong CO2 fluxes. CO2 fluxes are strong but opposite direction in the equatorial east Pacific Ocean, because the air-sea CO2 partial pressure difference is the largest in the global cceans. The results differ from the previous studies calculated using the wind speed. It is demonstrated that the air-sea transfer velocity is very important for estimating air-sea CO2 flux. It is critical to have an accurate estimation for improving calculation of CO2 flux within climate change studies.
基金Public Science and Technology Research Funds Projects of Ocean under contract No.200905012a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD) of China
文摘Using data from the European remote sensing scatterometer （ERS-2） from July 1997 to August 1998, glob- al distributions of the air-sea CO2 transfer velocity and flux are retrieved. A new model of the air-sea CO2 transfer velocity with surface wind speed and wave steepness is proposed. The wave steepness （6） is re- trieved using a neural network （NN） model from ERS-2 scatterometer data, while the wind speed is directly derived by the ERS-2 scatterometer. The new model agrees well with the formulations based on the wind speed and the variation in the wind speed dependent relationships presented in many previous studies can be explained by this proposed relation with variation in wave steepness effect. Seasonally global maps of gas transfer velocity and flux are shown on the basis of the new model and the seasonal variations of the transfer velocity and flux during the 1 a period. The global mean gas transfer velocity is 30 cm/h after area-weighting and Schmidt number correction and its accuracy remains calculation with in situ data. The highest transfer velocity occurs around 60°N and 60°S, while the lowest on the equator. The total air to sea CO2 flux （calcu- lated by carbon） in that year is 1.77 Pg. The strongest source of CO2 is in the equatorial east Pacific Ocean, while the strongest sink is in the 68°N. Full exploration of the uncertainty of this estimate awaits further data. An effectual method is provided to calculate the effect of waves on the determination of air-sea CO2 transfer velociW and fluxes with ERS-2 scatterometer data.
基金The Shanghai Sailing Program of Science and Technology Commission of Shanghai Municipality of China under contract No.14YF1410300the Special Fund for Basic Scientific Research Business of Central Public Research Institutes of 2015 of China under contract No.JG1503+3 种基金the Postdoctoral Research Projects in Zhejiang Province of China under contract No.BSH1502044the Shanghai Young University Teachers Training Support Plan of Shanghai Municipal Education Commission of China under contract Nos A1-2035-15-0021-11and ZZegd14015the 2014 Research Projects of Shanghai Second Polytechnic University of China under contract No.A01GY14GX33the Project Funded by the Local College Capacity Building Program of Science and Technology Commission of Shanghai Municipality of China under contract No.13230502000
文摘The numerous factors influencing the air-sea carbon dioxide（CO_2） transfer velocity have been discussed for many years, yet the contributions of various factors have undergone little quantitative estimation. To better understand the mechanism of air-sea transfer, the effects of different factors are discussed on the air-sea transfer velocity and the various parametric models describing the phenomenon are classified and compared.Then, based on GAS EX-98 and ASGAMAGE data, wind models are evaluated and the effects of some factors are discussed quantitatively, including bubbles, waves, wind and so on by considering their interaction through a piecewise average approach. It is found that the air-sea CO_2 transfer velocity is not only the function of the wind speed, but is also affected by bubbles, wave parameters and other factors. Stepwise and linear regressions are used. When considering the wind speed, bubbles mediated and the significant wave height, the root mean square error is reduced from 34.53 cm/h to 16.96 cm/h. Discussing the various factors quantitatively can be useful in future assessments of a large spatial scale and long-term air-sea CO_2 flux and global change.
基金Project supported by the National Natural Science Foundation of China(Grant No.11971085)the Fund from the Chongqing Municipal Education Commission,China(Grant Nos.KJZD-M201800501 and CXQT19018)the Chongqing Research Program of Basic Research and Frontier Technology,China(Grant No.cstc2018jcyjAX0266)。
文摘An improved moving least square meshless method is developed for the numerical solution of the nonlinear improved Boussinesq equation. After the approximation of temporal derivatives, nonlinear systems of discrete algebraic equations are established and are solved by an iterative algorithm. Convergence of the iterative algorithm is discussed. Shifted and scaled basis functions are incorporated into the method to guarantee convergence and stability of numerical results. Numerical examples are presented to demonstrate the high convergence rate and high computational accuracy of the method.
基金supported by the National Natural Science Foundation of China(22109030,22021001)the Fundamental Research Funds for the Central Universities(20720220073)+3 种基金the Key Research and Development Program of Yunnan Province(202103AA080019)the Fujian Industrial Technology Development and Application Plan(2022I0002)the Guangdong Basic and Applied Basic Research Foundation(2019A1515111069,2021A1515010177)the financial support from Guangdong Basic and Applied Basic Research Foundation(2020A1515010886)。
文摘The emerging rocking-chair aqueous zinc-ion battery(AZIB)configuration provides a promising approach for realizing their practical applications by avoiding the critical drawbacks of Zn metal anodes including unsatisfactory Coulombic efficiency and low Zn utilization.Therefore,exploiting appropriate insertion-type anodes with fast charge-transfer kinetics is of great importance,and many modifications focusing on the improvement of electron transport and bulk Zn^(2+)diffusion have been proposed.However,the interfacial Zn^(2+)transfer determined by the desolvation process actually dominates the kinetics of overall battery reactions,which is mainly overlooked.Herein,the interlayer structure of Mo S_(2)is rationally co-intercalated with water and ethylene glycol(EG)molecules(Mo S2@EG),giving rise to a fast non-desolvation Zn^(2+)storage mechanism,which is verified by the extraordinarily smaller activation energy of interfacial Zn^(2+)transfer(4.66 k J mol^(-1))compared with that of pristine Mo S_(2)(56.78 k J mol^(-1)).Furthermore,the results of theoretical calculations,in-situ Raman and ex-situ characterizations also indicate the enhanced structural integrity of Mo S2@EG during cycling due to the enlarged interlayer spacing and charge screening effect induced by interlaminar EG molecules.Consequently,the Mo S_(2)@EG anode enables excellent cycling stability of both high-energy-density Mo_S2@EG||PVO(polyaniline intercalated V_(2)O_(5))and high-voltage Mo S2@EG||Na_(3)V_(2)(PO_(4))_2O_(2)F(NVPF)full batteries with neglectable capacity decay at-20℃.
基金financially supported by the National Natural Science Foundation of China (Nos. 51771058, 51801030)Natural Science Foundation of Guangdong Province (No. 2018A030310571)。
文摘Aqueous zinc-ion batteries(ZIBs) have attracted significant attentions because of low cost and high reliability. However, conventional ZIBs are severely limited by the development of high energy density cathode materials with reversible Zn^(2+)insertion/extraction. Herein, a conducting polymer intercalated MoO_(3)(PMO) with extensively extended interlayer spacing is developed as a high-performance ZIBs cathode material. The interlayer spacing of PMO is prominently increased which results in an improved Zn^(2+)mobility during charge and discharge process. More significantly, the electrochemical results reveals that the intercalation of PANI facilitates the charge storage and reinforces the layered structure of MoO_(3), leading to a high capacity and good cycling stability. DFT calculation further reveals the intercalation of PANI into MoO_(3)significantly lower Zn^(2+)diffusion barrier. Benefit from these advantages, the ZIBs based on PMO electrode delivers a considerable capacity of 157 m Ah/g at 0.5 A/g and ameliorative stability with 63.4%capacity retention after 1000 cycles.
基金supported by the National Natural Science Foundation of China(No.12202370)the Research Startup Fund of Chengdu University of Technology(No.10912-KYQD2022-09841).
文摘The analytical solution of a thermo-poro-elastic medium in static state weakened by a Griffith crack with finite width is presented.By virtue of the Fourier cosine and sine integral transform techniques,the mixed boundary-value problem is formulated as three pairs of dual integral equations,which are solved with the help of the Abel transform.In addition,the stress intensity factor of mode Ⅰ and the crack surface displacement are presented analytically.Numerical examples are performed to show the distribution of displacement and stress over the thermo-poro-elastic medium.The results indicate that the thermal load will increase or decrease the crack surface displacement,but has a weak influence on the stress intensity factor.The present work may benefit future engineering applications.
基金financially supported by the National Natural Science Foundation of China(No.81774141)。
文摘Objective: The aim of this study was to identify the potential pharmacological mechanisms of Gualou-Xiebai-Banxia decoction(GLXBBX) against unstable angina(UA). Materials and Methods: The active compounds of GLXBBX were collected from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, and their targets were predicted using the Swiss Target Prediction database. The targets associated with UA were obtained from the Online Mendelian Inheritance in Man, Gene Cards, and Therapeutic Target Database. Individual targets associated with UA and GLXBBX were cross-checked to identify the targets of GLXBBX involved in the treatment of UA. A protein–protein interaction network was built using the STRING online database. Cytoscape 3.7.2 software was used to screen out hub genes. Additional gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed using the cluster Profiler package in R. Results: A total of 28 bioactive compounds and 320 protein targets of GLXBBX associated with UA were screened out. Enrichment analysis indicated that the therapeutic effect of GLXBBX may be mediated through the PI3K/AKT, MAPK, and HIF-1 signaling pathways. Molecular docking suggested that the active compounds including Vitamin E, cavidine, and baicalein can bind to their protein receptors. Conclusions: This research confirmed the multifactorial effects of GLXBBX in the treatment of UA and laid the foundation for the experimental research on GLXBBX.
基金supported by the National Natural Science Foundation of China(Grant No.:52206070)Innovative Research Group Project of National Natural Science Foundation of China(Grant No.:52021004)+1 种基金Venture&Innovation Support Program for Chongqing Overseas Returnees(Grant No.:cx2021080)National Natural Science Foundation of China(Grant No.:52106074).
文摘Centrifugal granulation is one key step to enable waste heat recovery from the molten slag in the iron and steel industry.Yet,it remains unknown about the granulation characteristics of molten slag with different chemical compositions,especially at high throughput.In this work,we provided an experimental study on centrifugal granulation with four types of molten slags.The stage-specific centrifugal granulation was recorded and analyzed at first.Both effects of atomizer configuration and chemical compositions on granulation were investigated in detail.The cup-type atomizer favors film-mode disintegration and possesses better anti-adhesion capacity although the final granule size was not strongly affected by the atomizer configuration.Most importantly,centrifugal granulation has been demonstrated with appreciable adaptability to composition-specific blast furnace(BF)slag with binary basicity of 0.9-1.3.The present study not only sheds light on the modest effect of the chemical composition of molten slag on centrifugal granulation characteristics,but also gains credit for the adaptivity of CGATER.
