Inflammation-related indicators to distinguish between gastric stromal tumors and leiomyomas:A retrospective study

BACKGROUND Gastric leiomyomas and gastric stromal tumors are the most common types of gastric tumors encountered.In recent years,the incidence of the two types of tumors has been increasing,but the differential diagnosis is still a challenge in clinical work.However,as there are many reports on stromal tumors and inflammation-related indicators are gradually being paid attention to as important factors in predicting tumor prognosis,the two main purposes of this study were to explore the inflammation-related differences between the two types of tumors and to develop a nomogram as a predictive model.AIM To explore the differences in platelet-lymphocyte ratio(PLR),neutrophillymphocyte ratio(NLR),lymphocyte mononuclear cell ratio(LMR),and SII between the two types of tumors,and simultaneously create the nomogram model.METHODS This study enrolled 88 patients in the gastric stromal tumor group and 56 patients in the gastric leiomyoma group,and the relevant data of the two groups were entered into the system for an integrated analysis.The primary objective of this study was to identify the differences in the inflammation index between the two types of tumors.RESULTS There were statistically significant differences between the two groups in sex,age,and tumor location.In comparison,gastric leiomyomas seem to be more common in women,young patients,and gastric cardia,which is in line with our previous research;the groups showed the following statistical differences:PLR(158.2%vs 134.3%,P=0.028),NLR(2.35 vs 1.68,P=0.000),LMR(5.75 vs 10.8,P=0.004),and SII(546.2 vs 384.3,P=0.003).The results of the multivariate logistic regression analysis showed that sex,age,tumor location,and LMR were independent risk factors for the identification of the two types of tumors.After considering the risk factors selected by the above analysis into the predictive model,a predictive model for distinguishing gastrointestinal stromal tumors from gastric leiomyomas was established as the nomogram.CONCLUSION Gastric leiomyomas and gastric stromal tumors are not only different in factors such as age of the patient,but also in inflammatory indicators such as LMR and PLR.We have established a predictive model related to the laboratory indicators and are looking forward to further research conducted in this clinical area.

Structure and mechanical properties of nc-TiC/a-C:H nanocomposite films deposited by filtered cathodic arc technique

nc-Ti C/a-C：H nanocomposite films were prepared by filtered cathodic arc technique. The influence of C_2H_2/Ar flow ratio on the composition, structure, and mechanical properties of films was investigated by X-ray photoelectron spectroscopy（XPS）, X-ray diffraction（XRD）, Fourier transform infrared spectroscopy（FTIR）,Raman spectroscopy, nanoindentation, and ball-on-disc tribometry. The films show a nanocomposite structure in which Ti C crystallites are embedded in the amorphous matrix of a-C：H phase. C content in films increases with the flow ratio of C_2H_2/Ar, simultaneously, the crystallite size of TiC decreases. Contrary to the nc-Ti C/a-C：H films deposited by magnetron sputtering in which the sp3 C content increases with C_2H_2 flow rate, the increase of C_2H_2 flow rate leads to the increase of sp2 C content in films deposited by filtered cathodic arc technique. The nc-Ti C/a-C：H films deposited by cathodic arc technique have a pronounced hardness maximum of 30 GPa under the C_2H_2/Ar flow ratio of 12. Tribological performance of films is controlled by the sp2 content in films. Higher sp2 content promotes the formation of graphite-like transfer layer during sliding,and results in lower wear rate and friction coefficient.