AIM: To investigate the efficacy of tandospirone in patients with irritable bowel syndrome-diarrhea(IBS-D) and anxiety in a prospective, randomized, controlled study.METHODS: Two hundred patients with IBS-D and modera...AIM: To investigate the efficacy of tandospirone in patients with irritable bowel syndrome-diarrhea(IBS-D) and anxiety in a prospective, randomized, controlled study.METHODS: Two hundred patients with IBS-D and moderate anxiety were randomized to receive pinaverium and tandospirone(arm A) or pinaverium and placebo(arm B). Tandospirone or placebo was given thrice daily at a fixed dose of 10 mg and pinaverium was given thrice daily at a fixed dose of 50 mg. The duration of treatment was 8 wk. Patients were assessed for abdominal pain and diarrhea. Anxiety was evaluated using the Hamilton Rating Scale for Anxiety(HAM-A). The primary study endpoints were response rates forabdominal pain and diarrhea. The secondary study endpoints were response rates for anxiety. Adverse events were also evaluated.RESULTS: One hundred and seventy of 200 patients(82 patients in arm A and 88 patients in arm B) completed the study. Demographic and baseline characteristics of the 200 participants were comparable in the two arms. At week 8, the overall response rate for abdominal pain and diarrhea was 52.0% for arm A and 37.0% for arm B(P < 0.05). The HAM-A score showed that the response rate was 61.0% for arm A and 21.0% for arm B(P < 0.01). The treatments were well tolerated and no significant adverse events were reported.CONCLUSION: Tandospirone is effective and can be combined with pinaverium in IBS-D patients with anxiety.展开更多
BACKGROUND Non-Hodgkin’s lymphoma(NHL)can involve extralymphatic organs,resulting in diverse clinical manifestations,especially if the endocrine organs are affected.This type of involvement can often be difficult to ...BACKGROUND Non-Hodgkin’s lymphoma(NHL)can involve extralymphatic organs,resulting in diverse clinical manifestations,especially if the endocrine organs are affected.This type of involvement can often be difficult to detect accurately.Until now,no patients with NHL and concomitant bilateral adrenal and hypothalamic involvement have been reported.The purpose of this article is to discuss the diagnosis and treatment of lymphoma with bilateral adrenal gland and hypothalamic involvement so as to help physicians avoid misdiagnosis and missed diagnosis.CASE SUMMARY We describe a case of a 52-years-old male patient with bilateral adrenal masses,who presented with a fever of unknown origin on admission.Subsequently,hypopituitarism of the anterior pituitary followed by posterior pituitary developed.18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography(PET/CT)showed lesions with a high metabolism in both adrenal glands,hypothalamus,left supraclavicular lymph nodes,and other organs.The etiological diagnosis was determined based on a left supraclavicular lymph node biopsy.The patient,who eventually present with panhypopituitarism,was finally diagnosed with diffuse large B cell lymphoma with bilateral adrenal gland and hypothalamic involvement.After immunochemotherapy,glucocorticoids administration and desmopressin acetate replacement therapy,the symptoms of fever and panhypopituitarism improved,and all the lesions reduced in size.CONCLUSION This report demonstrates that,although synchronous involvement of two endocrine organs is rare in NHL,extra caution should be taken when dysfunction occurs in multiple endocrine organs.展开更多
Objective To study the chemical constituents from Pericarpium Citri Reticulatae (Citrus reticulata). Methods The chemical constituents were isolated and purified by silica gel column, Sephadex LH-20, and ODS column ...Objective To study the chemical constituents from Pericarpium Citri Reticulatae (Citrus reticulata). Methods The chemical constituents were isolated and purified by silica gel column, Sephadex LH-20, and ODS column chromatography. The structures were identified by spectral data. Results Nineteen compounds were isolated and identified as 4',5,6,7-tetramethoxyflavone (1), 3,3',4',5,6,7,8-heptmethoxyflavone (2), sinensetin (3), 5-O-demethylnobiletin (4), tangeretin (5), nobiletin (6), apigenin (7), 5-O- desmethyltangeretin (8), 5,7-dihydroxy-3,3',4',6-tetramethoxyflavone (9), pachypodol (10), 4',5,6,7-tetramethoxyflavanone (11), 3',4',5,7,8-pentamethoxyflavanone (12), agestricin C (13), scoparone (14), isoscopoletin (15), hesperidin (16), didymin (17), methylhesperidine (18), and naringin (19). Conclusion Compounds 9-15 are obtained from this plant for the first time.展开更多
Objective To study the chemical constituents from the roots of Millettia speciosa.Methods The chemical constituents were isolated and purified by silica gel, Sephadex LH-20, and ODS column chromatography. The structur...Objective To study the chemical constituents from the roots of Millettia speciosa.Methods The chemical constituents were isolated and purified by silica gel, Sephadex LH-20, and ODS column chromatography. The structures were identified by means of spectral data. Results Fifteen compounds were isolated and identified as naringenin(1), liquiritigenin(2), garbanzol(3), 7-hydroxy-6,4′- dimethoxyisoflavone(4), calycosin(5), 2′,5′,7-trihydroxy-4′-methoxyisoflavone(6), 2′-hydroxybiochanin A(7), 6-methoxycalopogonium isoflavone A(8), demethylmedicarpin(9), 4,4′-dihydroxy-2′-methoxychalcone(10), 2′,4′-dihydroxy-4-methoxychalcone(11), rhododendrol(12), secoisolariciresinol(13), bisdihydrosiringenin(14), and polystachyol(15). Conclusion All compounds are obtained from this plant for the first time.展开更多
Objective: To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in Chinese population, we performed a meta-analysis in this paper. Meth...Objective: To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in Chinese population, we performed a meta-analysis in this paper. Methods: We searched PubMed, Embase, the Science Citation Index (SCI), the China Biological Medicine database (CBM), the China National Knowledge Infrastructure (CNKI), and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: The lit- erature search yielded 448 studies, in which 10 case-control studies including 1 694 cases and 1 456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 (95% CI, 0.89-1.34) for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 (95% CI, 1.09-1.49) in the B1B1 carriers versus B2B2 or B1B2 carriers. Conclusions: In the present study, the TaqIB poly- morphism of CETP was found to be associated with CAD in the Chinese population.展开更多
文摘AIM: To investigate the efficacy of tandospirone in patients with irritable bowel syndrome-diarrhea(IBS-D) and anxiety in a prospective, randomized, controlled study.METHODS: Two hundred patients with IBS-D and moderate anxiety were randomized to receive pinaverium and tandospirone(arm A) or pinaverium and placebo(arm B). Tandospirone or placebo was given thrice daily at a fixed dose of 10 mg and pinaverium was given thrice daily at a fixed dose of 50 mg. The duration of treatment was 8 wk. Patients were assessed for abdominal pain and diarrhea. Anxiety was evaluated using the Hamilton Rating Scale for Anxiety(HAM-A). The primary study endpoints were response rates forabdominal pain and diarrhea. The secondary study endpoints were response rates for anxiety. Adverse events were also evaluated.RESULTS: One hundred and seventy of 200 patients(82 patients in arm A and 88 patients in arm B) completed the study. Demographic and baseline characteristics of the 200 participants were comparable in the two arms. At week 8, the overall response rate for abdominal pain and diarrhea was 52.0% for arm A and 37.0% for arm B(P < 0.05). The HAM-A score showed that the response rate was 61.0% for arm A and 21.0% for arm B(P < 0.01). The treatments were well tolerated and no significant adverse events were reported.CONCLUSION: Tandospirone is effective and can be combined with pinaverium in IBS-D patients with anxiety.
文摘BACKGROUND Non-Hodgkin’s lymphoma(NHL)can involve extralymphatic organs,resulting in diverse clinical manifestations,especially if the endocrine organs are affected.This type of involvement can often be difficult to detect accurately.Until now,no patients with NHL and concomitant bilateral adrenal and hypothalamic involvement have been reported.The purpose of this article is to discuss the diagnosis and treatment of lymphoma with bilateral adrenal gland and hypothalamic involvement so as to help physicians avoid misdiagnosis and missed diagnosis.CASE SUMMARY We describe a case of a 52-years-old male patient with bilateral adrenal masses,who presented with a fever of unknown origin on admission.Subsequently,hypopituitarism of the anterior pituitary followed by posterior pituitary developed.18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography(PET/CT)showed lesions with a high metabolism in both adrenal glands,hypothalamus,left supraclavicular lymph nodes,and other organs.The etiological diagnosis was determined based on a left supraclavicular lymph node biopsy.The patient,who eventually present with panhypopituitarism,was finally diagnosed with diffuse large B cell lymphoma with bilateral adrenal gland and hypothalamic involvement.After immunochemotherapy,glucocorticoids administration and desmopressin acetate replacement therapy,the symptoms of fever and panhypopituitarism improved,and all the lesions reduced in size.CONCLUSION This report demonstrates that,although synchronous involvement of two endocrine organs is rare in NHL,extra caution should be taken when dysfunction occurs in multiple endocrine organs.
基金Project of Guangdong Natural Science Foundation(No.2015A030310284,No.2015A030312001)Project of Chinese Public Welfare Industry Special(Agriculture)Research(No.201503142-03)Project of Agricultural Research in Guangdong Province(No.2015A020209065)
文摘Objective To study the chemical constituents from Pericarpium Citri Reticulatae (Citrus reticulata). Methods The chemical constituents were isolated and purified by silica gel column, Sephadex LH-20, and ODS column chromatography. The structures were identified by spectral data. Results Nineteen compounds were isolated and identified as 4',5,6,7-tetramethoxyflavone (1), 3,3',4',5,6,7,8-heptmethoxyflavone (2), sinensetin (3), 5-O-demethylnobiletin (4), tangeretin (5), nobiletin (6), apigenin (7), 5-O- desmethyltangeretin (8), 5,7-dihydroxy-3,3',4',6-tetramethoxyflavone (9), pachypodol (10), 4',5,6,7-tetramethoxyflavanone (11), 3',4',5,7,8-pentamethoxyflavanone (12), agestricin C (13), scoparone (14), isoscopoletin (15), hesperidin (16), didymin (17), methylhesperidine (18), and naringin (19). Conclusion Compounds 9-15 are obtained from this plant for the first time.
基金Project of Chinese 12th Five-year Science and Technology(No.2015BAD16B09)Guangdong Natural Science Foundation(No.2015A030310284)Project of Chinese Public Welfare Industry Special(Agriculture) Research(No.201503142-03)
文摘Objective To study the chemical constituents from the roots of Millettia speciosa.Methods The chemical constituents were isolated and purified by silica gel, Sephadex LH-20, and ODS column chromatography. The structures were identified by means of spectral data. Results Fifteen compounds were isolated and identified as naringenin(1), liquiritigenin(2), garbanzol(3), 7-hydroxy-6,4′- dimethoxyisoflavone(4), calycosin(5), 2′,5′,7-trihydroxy-4′-methoxyisoflavone(6), 2′-hydroxybiochanin A(7), 6-methoxycalopogonium isoflavone A(8), demethylmedicarpin(9), 4,4′-dihydroxy-2′-methoxychalcone(10), 2′,4′-dihydroxy-4-methoxychalcone(11), rhododendrol(12), secoisolariciresinol(13), bisdihydrosiringenin(14), and polystachyol(15). Conclusion All compounds are obtained from this plant for the first time.
基金Project supported by the National Natural Science Foundation of China(Nos. 30900526 and 81070250)the Fundamental Research Funds for the Central Universitiesthe China Postdoctoral Science Foundation(No. 20100471616)
文摘Objective: To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in Chinese population, we performed a meta-analysis in this paper. Methods: We searched PubMed, Embase, the Science Citation Index (SCI), the China Biological Medicine database (CBM), the China National Knowledge Infrastructure (CNKI), and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: The lit- erature search yielded 448 studies, in which 10 case-control studies including 1 694 cases and 1 456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 (95% CI, 0.89-1.34) for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 (95% CI, 1.09-1.49) in the B1B1 carriers versus B2B2 or B1B2 carriers. Conclusions: In the present study, the TaqIB poly- morphism of CETP was found to be associated with CAD in the Chinese population.