Association of hidradenitis suppurativa with Crohn’s disease

Hidradenitis suppurativa(HS)is a chronic inflammatory skin disorder characterized by recurrent nodules,abscesses,and sinus tracts.Crohn’s disease(CD)is characterized by inflammation of the entire digestive tract and belongs to the group of inflammatory bowel diseases,and there are many extraintestinal manifestations,among which hidradenitis suppurativa is one of the rare extraintestinal manifestations.There appears to be a strong association between CD and HS based on clinical and histological similarities(sinus tract development,granulomatous inflammation,and scarring),intersections in pathogenesis(genetic loci,immune dysregulation mechanisms,and microbiome changes),and commonality in treatment.In this review,we summarize recent studies on the association between HS and CD.

Differential coupling contributes to synchronization via a capacitor connection between chaotic circuits

Nonlinear oscillators and circuits can be coupled to reach synchronization and consensus. The occurrence of complete synchronization means that all oscillators can maintain the same amplitude and phase, and it is often detected between identical oscillators. However, phase synchronization means that the coupled oscillators just keep pace in oscillation even though the amplitude of each node could be different. For dimensionless dynamical systems and oscillators, the synchronization approach depends a great deal on the selection of coupling variable and type. For nonlinear circuits, a resistor is often used to bridge the connection between two or more circuits, so voltage coupling can be activated to generate feedback on the coupled circuits. In this paper, capacitor coupling is applied between two Pikovsk-Rabinovich(PR) circuits, and electric field coupling explains the potential mechanism for differential coupling. Then symmetric coupling and cross coupling are activated to detect synchronization stability, separately. It is found that resistor-based voltage coupling via a single variable can stabilize the synchronization, and the energy flow of the controller is decreased when synchronization is realized. Furthermore, by applying appropriate intensity for the coupling capacitor, synchronization is also reached and the energy flow across the coupling capacitor is helpful in regulating the dynamical behaviors of coupled circuits, which are supported by a continuous energy exchange between capacitors and the inductor. It is also confirmed that the realization of synchronization is dependent on the selection of a coupling channel. The approach and stability of complete synchronization depend on symmetric coupling, which is activated between the same variables. Cross coupling between different variables just triggers phase synchronization. The capacitor coupling can avoid energy consumption for the case with resistor coupling, and it can also enhance the energy exchange between two coupled circuits.