A visible-light-driven rhodamine B-catalyzed transition-metal-free 3-ethoxycarbonylmethylation of 2-aryl-2H-indazoles and imidazo[1,2-a]pyridines(40 examples)using commercially availableα-bromoesters was realized in ...A visible-light-driven rhodamine B-catalyzed transition-metal-free 3-ethoxycarbonylmethylation of 2-aryl-2H-indazoles and imidazo[1,2-a]pyridines(40 examples)using commercially availableα-bromoesters was realized in water.This protocol features sustainability,operational simplicity,mild reaction conditions,and remarkable substrate scope.Importantly,α-bromoamides are also appropriate substrates for affording 3-carbamylmethylation products.It could be used for the synthesis of the drug zolpidem and the late-stage modification of natural products.展开更多
基金We acknowledge the financial support from the National Natural Science Foundation of China(82003585 and 21971224)the Postgraduate Education Reform Project of Henan Province(2019SJGLX008Y and 2019SJGLX034Y)the Postgraduate Education Reform and Quality Improvement Project of Henan Province(YJS2021AL079).
文摘A visible-light-driven rhodamine B-catalyzed transition-metal-free 3-ethoxycarbonylmethylation of 2-aryl-2H-indazoles and imidazo[1,2-a]pyridines(40 examples)using commercially availableα-bromoesters was realized in water.This protocol features sustainability,operational simplicity,mild reaction conditions,and remarkable substrate scope.Importantly,α-bromoamides are also appropriate substrates for affording 3-carbamylmethylation products.It could be used for the synthesis of the drug zolpidem and the late-stage modification of natural products.
