目的评估经尿道前列腺等离子双极电切术(TUPKP)治疗良性前列腺增生(BPH)的相关并发症类型及其发生率。方法计算机检索PubMed、Embase、Web of Science、The Cochrane Library、中国知网、维普、中国生物医学文献数据库及万方数据库,搜...目的评估经尿道前列腺等离子双极电切术(TUPKP)治疗良性前列腺增生(BPH)的相关并发症类型及其发生率。方法计算机检索PubMed、Embase、Web of Science、The Cochrane Library、中国知网、维普、中国生物医学文献数据库及万方数据库,搜集有关TUPKP治疗BPH并发症发生率的横断面研究,检索时限均至2020年9月15日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用R软件meta程序包进行Meta分析。结果共纳入27项研究,包括5247例患者。文献中报告的并发症有尿道狭窄、暂时性尿失禁、排尿困难、需要输血等31种。Meta分析结果显示:发生率最高的并发症为术后6个月射精异常,其次是术后逆行性射精、术后尿路刺激症状,发生率分别为75.15%[95%CI(68.25%,81.47%)]、24.77%[95%CI(0.00%,73.81%)]和17.15%[95%CI(9.61%,26.22%)]。其他并发症发生率均低于10%,有21种并发症的发生率低于3%。15项研究报告了经尿道电切综合征,且发生率均为0。结论当前证据显示,TUPKP治疗BPH术后并发症种类较多,发生率差异较大。展开更多
Respiratory syncytial virus (RSV) infection is the primary cause of respiratory disease in infants. The formalin-inactivated RSV (FI-RSV) vaccine resulted in an enhanced respiratory disease (ERD) in infants upon natur...Respiratory syncytial virus (RSV) infection is the primary cause of respiratory disease in infants. The formalin-inactivated RSV (FI-RSV) vaccine resulted in an enhanced respiratory disease (ERD) in infants upon natural RSV infection, which is a major obstacle for development of safe and efficacious vaccines. Excessive and uncontrolled Th immune responses could be involved in the ERD. Agonists of TLRs are used as adjuvants to guide the type of immune response induced by vaccines. We evaluated the impact of lipopolysaccharide (LPS), the agonist of TLR4, on ERD as the adjuvant of FI-RSV. The results showed that LPS remarkably inhibited FI-RSV-enhanced lung inflammation, mucus production, airway inflammatory cell infiltration, and inflammatory cytokines following RSV challenge. Interestingly, LPS inhibited both Th2 and Th17 type cytokines in lungs of FI-RSV-immunized mice following RSV challenge, without an increase in the Thl type cytokines, suggesting a controlled immune response. In contrast, Pam3Cys and Poly(I:C), the agonist of TLR1/2 or TLR3, partly inhibited FI-RSV-enhanced lung inflammation. Pam3Cys inhibited Th17 type cytokine IL-17, but promoted both Th1 and Th2 type cytokines. Poly(I:C) inhibited Th2 and Th 17 type cytokines, but promoted Th1 type cytokines. In addition, LPS promoted IgG and IgG2a antibody production, which might provide protection from RSV challenge. These results suggest that LPS inhibits ERD without impairment in antibody production and protection, and the mechanism appears to be related with regulation of Th responses induced by FI-RSV.展开更多
Dear Editor,I am Dr.Yi Liu from Department of Ophthalmology,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing,China.I write to present a case of severe corneal acid-burn...Dear Editor,I am Dr.Yi Liu from Department of Ophthalmology,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing,China.I write to present a case of severe corneal acid-burn injury and describe a novel surgery namely,deep lamellar endothelial keratoplasty(DLEK)and anterior lamellar keratoplasty(ALK)with limbal allograft(LA).展开更多
文摘目的评估经尿道前列腺等离子双极电切术(TUPKP)治疗良性前列腺增生(BPH)的相关并发症类型及其发生率。方法计算机检索PubMed、Embase、Web of Science、The Cochrane Library、中国知网、维普、中国生物医学文献数据库及万方数据库,搜集有关TUPKP治疗BPH并发症发生率的横断面研究,检索时限均至2020年9月15日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用R软件meta程序包进行Meta分析。结果共纳入27项研究,包括5247例患者。文献中报告的并发症有尿道狭窄、暂时性尿失禁、排尿困难、需要输血等31种。Meta分析结果显示:发生率最高的并发症为术后6个月射精异常,其次是术后逆行性射精、术后尿路刺激症状,发生率分别为75.15%[95%CI(68.25%,81.47%)]、24.77%[95%CI(0.00%,73.81%)]和17.15%[95%CI(9.61%,26.22%)]。其他并发症发生率均低于10%,有21种并发症的发生率低于3%。15项研究报告了经尿道电切综合征,且发生率均为0。结论当前证据显示,TUPKP治疗BPH术后并发症种类较多,发生率差异较大。
基金This study was supported by grants from the National Natural Science Foundation of China (No. 81671635 and No. 31240084)Natural Science Foundation of Hebei Province (No.H2016206473).
文摘Respiratory syncytial virus (RSV) infection is the primary cause of respiratory disease in infants. The formalin-inactivated RSV (FI-RSV) vaccine resulted in an enhanced respiratory disease (ERD) in infants upon natural RSV infection, which is a major obstacle for development of safe and efficacious vaccines. Excessive and uncontrolled Th immune responses could be involved in the ERD. Agonists of TLRs are used as adjuvants to guide the type of immune response induced by vaccines. We evaluated the impact of lipopolysaccharide (LPS), the agonist of TLR4, on ERD as the adjuvant of FI-RSV. The results showed that LPS remarkably inhibited FI-RSV-enhanced lung inflammation, mucus production, airway inflammatory cell infiltration, and inflammatory cytokines following RSV challenge. Interestingly, LPS inhibited both Th2 and Th17 type cytokines in lungs of FI-RSV-immunized mice following RSV challenge, without an increase in the Thl type cytokines, suggesting a controlled immune response. In contrast, Pam3Cys and Poly(I:C), the agonist of TLR1/2 or TLR3, partly inhibited FI-RSV-enhanced lung inflammation. Pam3Cys inhibited Th17 type cytokine IL-17, but promoted both Th1 and Th2 type cytokines. Poly(I:C) inhibited Th2 and Th 17 type cytokines, but promoted Th1 type cytokines. In addition, LPS promoted IgG and IgG2a antibody production, which might provide protection from RSV challenge. These results suggest that LPS inhibits ERD without impairment in antibody production and protection, and the mechanism appears to be related with regulation of Th responses induced by FI-RSV.
文摘Dear Editor,I am Dr.Yi Liu from Department of Ophthalmology,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing,China.I write to present a case of severe corneal acid-burn injury and describe a novel surgery namely,deep lamellar endothelial keratoplasty(DLEK)and anterior lamellar keratoplasty(ALK)with limbal allograft(LA).
