We report a^19F nuclear magnetic resonance(NMR)study on single-crystal KCa2 Fe4As4F2(Tc^33.3 K).The 19F NMR spectral shape of KCa2Fe4As4F2 is weakly dependent on temperature and the Knight shift is small,which implies...We report a^19F nuclear magnetic resonance(NMR)study on single-crystal KCa2 Fe4As4F2(Tc^33.3 K).The 19F NMR spectral shape of KCa2Fe4As4F2 is weakly dependent on temperature and the Knight shift is small,which implies weak coupling between the Ca F layer and the Fe As layer.The temperature dependence of 1/^19T1 shows a hump below Tc,however the 1/^75T1 decreases just below Tc,which implies that there are strong in-plane magnetic fluctuations in the Ca F layers than in the Fe As layers.This may be caused by the motion of vortices.The absence of the coherence peak suggests unconventional superconductivity in KCa2Fe4As4F2.展开更多
Virus-induced asthma is prevalent among children,but its underlying mechanisms are unclear.Accumulated evidence indicates that early-life respiratory virus infection increases susceptibility to allergic asthma.Nonethe...Virus-induced asthma is prevalent among children,but its underlying mechanisms are unclear.Accumulated evidence indicates that early-life respiratory virus infection increases susceptibility to allergic asthma.Nonetheless,the relationship between systemic virus infections,such as enterovirus infection,and the ensuing effects on allergic asthma development is unknown.Early-life enterovirus infection was correlated with higher risks of allergic diseases in children.Adult mice exhibited exacerbated mite allergen-induced airway inflammation following recovery from EV-A71 infection in the neonatal period.Bone marrow-derived macrophages(BMDMs)from recovered EV-A71-infected mice showed sustained innate immune memory(trained immunity)that could drive naïve T helper cells toward Th2 and Th17 cell differentiation when in contact with mites.Adoptive transfer of EV-A71-trained BMDMs induced augmented allergic inflammation in naïve recipient mice,which was inhibited by 2-deoxy-D-glucose(2-DG)pretreatment,suggesting that trained macrophages following enterovirus infection are crucial in the progression of allergic asthma later in life.展开更多
基金Supported by the National Key Research and Development Program of China under Grant No 2017YFA0302901the National Basic Research Program of China under Grant No 2015CB921304+1 种基金the National Science Foundation of China under Grant Nos11674375 and 11634015the Strategic Priority Research Program and Key Research Program of Frontier Sciences of the Chinese Academy of Sciences under Grant No XDB07020200
文摘We report a^19F nuclear magnetic resonance(NMR)study on single-crystal KCa2 Fe4As4F2(Tc^33.3 K).The 19F NMR spectral shape of KCa2Fe4As4F2 is weakly dependent on temperature and the Knight shift is small,which implies weak coupling between the Ca F layer and the Fe As layer.The temperature dependence of 1/^19T1 shows a hump below Tc,however the 1/^75T1 decreases just below Tc,which implies that there are strong in-plane magnetic fluctuations in the Ca F layers than in the Fe As layers.This may be caused by the motion of vortices.The absence of the coherence peak suggests unconventional superconductivity in KCa2Fe4As4F2.
基金This study was,in part,supported by the Centre of Allergy and Mucosal Immunity,Headquarters of University Advancement at the National Cheng Kung University,Ministry of Education,Taiwan.H.J.T is supported in part by a grant from the National Health Research Institutes(PI:Tsai,PH-101-PP-14,PH-101-SP-14,and PH-108-PP-08).
文摘Virus-induced asthma is prevalent among children,but its underlying mechanisms are unclear.Accumulated evidence indicates that early-life respiratory virus infection increases susceptibility to allergic asthma.Nonetheless,the relationship between systemic virus infections,such as enterovirus infection,and the ensuing effects on allergic asthma development is unknown.Early-life enterovirus infection was correlated with higher risks of allergic diseases in children.Adult mice exhibited exacerbated mite allergen-induced airway inflammation following recovery from EV-A71 infection in the neonatal period.Bone marrow-derived macrophages(BMDMs)from recovered EV-A71-infected mice showed sustained innate immune memory(trained immunity)that could drive naïve T helper cells toward Th2 and Th17 cell differentiation when in contact with mites.Adoptive transfer of EV-A71-trained BMDMs induced augmented allergic inflammation in naïve recipient mice,which was inhibited by 2-deoxy-D-glucose(2-DG)pretreatment,suggesting that trained macrophages following enterovirus infection are crucial in the progression of allergic asthma later in life.
