Fast radio bursts(FRBs) are highly dispersed millisecond-duration radio bursts,[1,2]of which the physical origin is still not fully understood. FRB 20201124A is one of the most actively repeating FRBs. In this paper, ...Fast radio bursts(FRBs) are highly dispersed millisecond-duration radio bursts,[1,2]of which the physical origin is still not fully understood. FRB 20201124A is one of the most actively repeating FRBs. In this paper, we present the collection of 1863 burst dynamic spectra of FRB 20201124A measured with the Five-hundred-meter Aperture Spherical radio Telescope(FAST). The current collection, taken from the observation during the FRB active phase from April to June 2021, is the largest burst sample detected for any FRB so far. The standard PSRFITs format is adopted, including dynamic spectra of the burst, and the time information of the dynamic spectra, in addition, mask files help readers to identify the pulse positions are also provided. The dataset is available in Science Data Bank, with the link https://www.doi.org/10.57760/sciencedb.j00113.00076.展开更多
Background:Long non-coding RNAs(lncRNAs)can influence the necroptosis process,which is essential in malignant tumors.But no studies have looked at the predictive value of necroptosis-related lncRNAs in cervical cancer...Background:Long non-coding RNAs(lncRNAs)can influence the necroptosis process,which is essential in malignant tumors.But no studies have looked at the predictive value of necroptosis-related lncRNAs in cervical cancer(CC).Using necroptosis-related lncRNAs,we developed a prediction signature to predict the prognosis of CC patients.Method:We gathered the RNA-seq and related clinical data for patients with CC from the Cancer Genome Atlas(TCGA)database.To identify lncRNAs linked to necroptosis,we then conducted univariate and multivariate Cox regression analyses.Co-expression network analysis,least absolute shrinkage selection operator(LASSO)regression analysis and multivariate Cox regression analyses were subsequently used to further filter necroptosis-related lncRNAs signature and construct a predictive model.Finally,we examined the medication sensitivity between the two risk groups.We performed a single-sample gene set enrichment analysis(ssGSEA)to investigate the association between the predictive signature and the tumor immune microenvironment.Result:Six necroptosis-related lncRNAs(AL021807.1,AC026803.2,AC015819.1,AC233728.1,AL158166.1,NKILA)that are independently connected to the overall survival(OS)time of CC patients make up the signature we created.For predicting the 1-,3-,and 5-year survival rates,the areas under the receiver operating characteristic(ROC)curve(AUC)were 0.72,0.791,and 0.808.It was determined that the risk score model was a separate prognostic component.The Kaplan-Meier analysis revealed that the prognosis for CC patients in the high-risk category was worse.Low-risk CC patients had more active immune systems and responded better to PD1/L1 immunotherapy.Conclusion:The signature based on necroptosis-related lncRNAs is a reliable biomarker,which is more likely to independently predict the prognosis of patients with CC and offer a foundation for the pathogenesis of necroptosis-related lncRNAs in CC.It can also be utilized to direct the tailored therapy of CC patients.展开更多
In this study,we investigated the astronomical implications of Rastall gravity,particularly its behavior amidst a radiation field compared to Reissner-Nordström(RN)black holes.We found a crucial correlation betwe...In this study,we investigated the astronomical implications of Rastall gravity,particularly its behavior amidst a radiation field compared to Reissner-Nordström(RN)black holes.We found a crucial correlation between the dynamics of the accretion disk and the parameters Q and Nr,which properly reflect the influence of spacetime metrics on the disk’s appearance.Elevated electric charge Q causes contraction in the disk’s orbit due to enhanced gravitational effects,while higher Nr values lead to outward expansion,influenced by the attributes of the radiation field.Interestingly,the charged black holes surrounded by radiation fields exhibit distinct visual disparities from RN black holes.Brightness decreases and expansion occurs within the innermost stable circular orbit of the accretion disk with rising Nr values.Our study also reveals the process by which the accretion disk transitions from a conventional disk-like structure to a hat-like form at different observation angles,with the redshift effect gradually intensifying.Moreover,the results of the considered Rastall gravity radiation field are consistent with the constraints of the gravitational lensing of the host galaxy on Rastall gravity parameters,thereby enhancing the consistency between theoretical predictions and actual observations.展开更多
The image of a black hole(BH)consists of direct and secondary images that depend on the observer position.We investigate the optical appearance of a Schwarzschild BH in the context of a string cloud to reveal how the...The image of a black hole(BH)consists of direct and secondary images that depend on the observer position.We investigate the optical appearance of a Schwarzschild BH in the context of a string cloud to reveal how the BH’s observable characteristics are influenced by the inclination angle,string cloud parameter,and impact parameter.Following Luminet’s work[Astron.Astrophys.75,228(1979)],we adopt a semi-analytic method to calculate the total bending angle of the light ray and derive the direct and secondary images of the Schwarzschild string cloud BH.Our results show that an increase in the inclination angle leads to a more pronounced separation of the images.We consider the gravitational redshift and present the redshift distribution of the direct image while illustrating the flux distribution.We observe that the direct image exhibits blueshift and redshift simultaneously,and the asymmetry of the flux distribution increases with the inclination angle.Finally,we obtain the Schwarzschild string cloud BH image via a numerical simulation,which provides an approximate illustration of the EHT resolution.展开更多
基金supported by the National SKA Program of China (Grant Nos. 2020SKA0120100 and 2020SKA0120200)the National Natural Science Foundation of China (Grant Nos. 12041304, 11873067, 11988101, 12041303, 11725313, 11725314, 11833003, 12003028, 12041306, 12103089, U2031209, U2038105, and U1831207)+8 种基金the National Key Research and Development Program of China (Grant Nos. 2019YFA0405100, 2017YFA0402602, 2018YFA0404204, and 2016YFA0400801)Key Research Program of the Chinese Academy of Sciences (Grant No. QYZDJ-SSW-SLH021)Natural Science Foundation of Jiangsu Province (Grant No. BK20211000)Cultivation Project for FAST Scientific Payoff and Research Achievement of CAMS-CAS, the Strategic Priority Research Program on Space Science, the Western Light Youth Project of Chinese Academy of Sciences (Grant Nos. XDA15360000, XDA15052700, and XDB23040400)funding from the MaxPlanck Partner Group, the science research grants from the China Manned Space Project (Grant Nos. CMS-CSST2021-B11 and CMS-CSST-2021-A11)PKU development (Grant No. 7101502590)support from the XPLORER PRIZEsupported by Fundamental Research Funds for the Central Universities (Grant No. 14380046)the Program for Innovative Talents, Entrepreneur in Jiangsu。
文摘Fast radio bursts(FRBs) are highly dispersed millisecond-duration radio bursts,[1,2]of which the physical origin is still not fully understood. FRB 20201124A is one of the most actively repeating FRBs. In this paper, we present the collection of 1863 burst dynamic spectra of FRB 20201124A measured with the Five-hundred-meter Aperture Spherical radio Telescope(FAST). The current collection, taken from the observation during the FRB active phase from April to June 2021, is the largest burst sample detected for any FRB so far. The standard PSRFITs format is adopted, including dynamic spectra of the burst, and the time information of the dynamic spectra, in addition, mask files help readers to identify the pulse positions are also provided. The dataset is available in Science Data Bank, with the link https://www.doi.org/10.57760/sciencedb.j00113.00076.
文摘Background:Long non-coding RNAs(lncRNAs)can influence the necroptosis process,which is essential in malignant tumors.But no studies have looked at the predictive value of necroptosis-related lncRNAs in cervical cancer(CC).Using necroptosis-related lncRNAs,we developed a prediction signature to predict the prognosis of CC patients.Method:We gathered the RNA-seq and related clinical data for patients with CC from the Cancer Genome Atlas(TCGA)database.To identify lncRNAs linked to necroptosis,we then conducted univariate and multivariate Cox regression analyses.Co-expression network analysis,least absolute shrinkage selection operator(LASSO)regression analysis and multivariate Cox regression analyses were subsequently used to further filter necroptosis-related lncRNAs signature and construct a predictive model.Finally,we examined the medication sensitivity between the two risk groups.We performed a single-sample gene set enrichment analysis(ssGSEA)to investigate the association between the predictive signature and the tumor immune microenvironment.Result:Six necroptosis-related lncRNAs(AL021807.1,AC026803.2,AC015819.1,AC233728.1,AL158166.1,NKILA)that are independently connected to the overall survival(OS)time of CC patients make up the signature we created.For predicting the 1-,3-,and 5-year survival rates,the areas under the receiver operating characteristic(ROC)curve(AUC)were 0.72,0.791,and 0.808.It was determined that the risk score model was a separate prognostic component.The Kaplan-Meier analysis revealed that the prognosis for CC patients in the high-risk category was worse.Low-risk CC patients had more active immune systems and responded better to PD1/L1 immunotherapy.Conclusion:The signature based on necroptosis-related lncRNAs is a reliable biomarker,which is more likely to independently predict the prognosis of patients with CC and offer a foundation for the pathogenesis of necroptosis-related lncRNAs in CC.It can also be utilized to direct the tailored therapy of CC patients.
基金the National Natural Science Foundation of China(42230207)the Fundamental Research Funds for the Central Universities,China University of Geosciences(Wuhan)(G1323523064)the Sichuan Youth Science and Technology Innovation Research Team(21CXTD0038)。
文摘In this study,we investigated the astronomical implications of Rastall gravity,particularly its behavior amidst a radiation field compared to Reissner-Nordström(RN)black holes.We found a crucial correlation between the dynamics of the accretion disk and the parameters Q and Nr,which properly reflect the influence of spacetime metrics on the disk’s appearance.Elevated electric charge Q causes contraction in the disk’s orbit due to enhanced gravitational effects,while higher Nr values lead to outward expansion,influenced by the attributes of the radiation field.Interestingly,the charged black holes surrounded by radiation fields exhibit distinct visual disparities from RN black holes.Brightness decreases and expansion occurs within the innermost stable circular orbit of the accretion disk with rising Nr values.Our study also reveals the process by which the accretion disk transitions from a conventional disk-like structure to a hat-like form at different observation angles,with the redshift effect gradually intensifying.Moreover,the results of the considered Rastall gravity radiation field are consistent with the constraints of the gravitational lensing of the host galaxy on Rastall gravity parameters,thereby enhancing the consistency between theoretical predictions and actual observations.
基金Supported by the National Natural Science Foundation of China(11903025)the Natural Science Foundation of Sichuan Province,China(2022NSFSC1833)。
文摘The image of a black hole(BH)consists of direct and secondary images that depend on the observer position.We investigate the optical appearance of a Schwarzschild BH in the context of a string cloud to reveal how the BH’s observable characteristics are influenced by the inclination angle,string cloud parameter,and impact parameter.Following Luminet’s work[Astron.Astrophys.75,228(1979)],we adopt a semi-analytic method to calculate the total bending angle of the light ray and derive the direct and secondary images of the Schwarzschild string cloud BH.Our results show that an increase in the inclination angle leads to a more pronounced separation of the images.We consider the gravitational redshift and present the redshift distribution of the direct image while illustrating the flux distribution.We observe that the direct image exhibits blueshift and redshift simultaneously,and the asymmetry of the flux distribution increases with the inclination angle.Finally,we obtain the Schwarzschild string cloud BH image via a numerical simulation,which provides an approximate illustration of the EHT resolution.