Glioma is an aggressive malignant primary tumor in the central nervous system[1,2].Although the pathogenesis of glioma is unclear,the only identified environmental risk fac-tor is ionizing radiation[3].However,other f...Glioma is an aggressive malignant primary tumor in the central nervous system[1,2].Although the pathogenesis of glioma is unclear,the only identified environmental risk fac-tor is ionizing radiation[3].However,other factors also may alter the glioma risk,among which gene polymorphisms may play prominent role in glioma susceptibility.Base excision repair(BER)is a DNA repair mechanism that maintains genome integrity and guarantees DNA base modification properly.Many signifcant and common proteins involved in the BER pathway are associated with cancer.展开更多
基金supported by grants from the National Natural Science Foundation of China(81802346)the Discipline Promotion Project of the First Affiliated Hospital of Air Force Medical University(XJZT18MJ49).
文摘Glioma is an aggressive malignant primary tumor in the central nervous system[1,2].Although the pathogenesis of glioma is unclear,the only identified environmental risk fac-tor is ionizing radiation[3].However,other factors also may alter the glioma risk,among which gene polymorphisms may play prominent role in glioma susceptibility.Base excision repair(BER)is a DNA repair mechanism that maintains genome integrity and guarantees DNA base modification properly.Many signifcant and common proteins involved in the BER pathway are associated with cancer.
