Clinical features and treatment outcomes of primary ocular adnexal mucosa-associated lymphoid tissue lymphoma: a single center retrospective analysis of 64 patients in China

AIM: To investigate the clinical features, treatment and prognosis of primary ocular adnexal mucosa-associated lymphoid tissue lymphoma(POAML).METHODS: A retrospective analysis was performed on 64 patients with POAML who were admitted to the First Affiliated Hospital of Zhengzhou University from January 2006 to December 2018.RESULTS: With a median follow-up of 61 mo(range, 2-156 mo), estimated overall survival(OS) rate and progressionfree survival(PFS) rate at 10 y reached 94.5% and 61.5%, respectively. Median OS time and PFS time were not reached. During this period, only 3 patients died, but none of them died directly due to disease progression. One patient(1.6%) developed transformation to diffuse large B-cell lymphoma(DLBCL). Of the 56 patients achieved complete remission after first-line treatment, 5(8.9%) developed local and/or systemic relapse eventually. Patients ≥60 y had significantly shorter PFS than younger patients(P=0.01). For patients with early stages(Ann Arbor stage I and stage II), univariate analysis confirmed that radiotherapydose lower than 32 Gy were independently associated with shorter PFS(P=0.04). Other factors including gender, bone marrow involvement, the initial location of the disease, and the laterality were not associated with PFS.CONCLUSION: The data from our center indicate that POAML has a slow clinical progression and has an excellent clinical outcome. Patients with POAML harbor a continual risk of relaps and transformation to aggressive subtype of lymphoma.

Experimental and numerical investigations of the collapse of a laser-induced cavitation bubble near a solid wall

With the collapse of cavitation bubbles near the wall,micro-jets and shock waves will be formed,to generate a high-pressure load and to cause the cavitation damage on the surface of the hydraulic machinery.Due to the rapid development of the cavitation bubble collapse process(in the time scale of hundred nanoseconds),the time resolution of the conventional high-speed cameras should reach more than one million frames per second,which will limit the spatial resolution,and obscure the details of the cavitation bubble shape near the cavitation bubble collapse moment.In this paper,with the help of the laser cavitation bubble photogrammetry system with nanosecond-micron space-time resolution,the experiment is carried out for the cavitation bubble collapse morphology evolution near the wall.The morphological characteristics of the cavitation bubble collapse at specific times are analyzed.With the help of the OpenFOAM code,the collapse process of the cavitation bubble near the solid wall is calculated.It is shown that the cavitation bubble near the wall collapses in an axial symmetric heart shape and the micro-jet directed to the wall will pull the cavitation bubble towards the wall.The counter-jet generated in the rebound stage will drive the cavitation bubble to move away from the wall.The numerical simulation of the cavitation bubble shape in the collapse period is well consistent with the experimental results,but the ability to capture the shock wavefront needs to be improved.Under the conditions studied in this paper,the cavitation bubble collapse micro-jet velocity can reach up to a hundred meters per second both in the experiment and the numerical simulation.