Mesenchymal stem cell-derived exosomes regulate microglia phenotypes:a promising treatment for acute central nervous system injury

There is growing evidence that long-term central nervous system(CNS)inflammation exacerbates secondary deterioration of brain structures and functions and is one of the major determinants of disease outcome and progression.In acute CNS injury,brain microglia are among the first cells to respond and play a critical role in neural repair and regeneration.However,microglial activation can also impede CNS repair and amplify tissue damage,and phenotypic transformation may be responsible for this dual role.Mesenchymal stem cell(MSC)-derived exosomes(Exos)are promising therapeutic agents for the treatment of acute CNS injuries due to their immunomodulatory and regenerative properties.MSC-Exos are nanoscale membrane vesicles that are actively released by cells and are used clinically as circulating biomarkers for disease diagnosis and prognosis.MSC-Exos can be neuroprotective in several acute CNS models,including for stroke and traumatic brain injury,showing great clinical potential.This review summarized the classification of acute CNS injury disorders and discussed the prominent role of microglial activation in acute CNS inflammation and the specific role of MSC-Exos in regulating pro-inflammatory microglia in neuroinflammatory repair following acute CNS injury.Finally,this review explored the potential mechanisms and factors associated with MSCExos in modulating the phenotypic balance of microglia,focusing on the interplay between CNS inflammation,the brain,and injury aspects,with an emphasis on potential strategies and therapeutic interventions for improving functional recovery from early CNS inflammation caused by acute CNS injury.

Sensitivity analysis of spacecraft in micrometeoroids and orbital debris environment based on panel method

To reduce the risk of mission failure caused by the MM/OD impact of the spacecraft,it is necessary to optimize the design of the spacecraft.Spacecraft survivability assessment is the key technology in the optimal design of spacecraft.Spacecraft survivability assessment includes spacecraft impact sensitivity analysis and spacecraft component vulnerability analysis under MM/OD environment.The impact sensitivity refers to the probability of a spacecraft encountering an MM/OD impact while in orbit.Vulnerability refers to the probability that each component of a spacecraft may fail or malfunction when impacted by space debris.Yet this paper mainly analyzes the impact sensitivity and proposes a spacecraft sensitivity assessment method under the MM/OD environment based on a panel method.Under this panel method,a spacecraft geometric model is discretized into small panels,and whether they are impacted by MM/OD or not is determined through the analysis of the shielding or shadowing relationships between panels.The number of impacts on each panel is obtained through calculation,and accordingly the probability of each spacecraft component encountering MM/OD impact can be acquired,thus generating the impact sensibility.This paper extracts data from the NASA’s ORDEM2000,the ESA’s MASTER8 as well as the SDEEM2015(Space Debris Environmental Engineering Model developed by HIT),and uses the PCHIP(Piecewise Cubic Hermite Interpolating Polynomial)method to interpolate and fit the size-flux relationship of space debris.Compared with linear interpolation and cubic spline interpolation,the fitting results through the method are relatively more accurate.The feasibility of this method is also demonstrated through two actual examples shown in this paper,whose results are close to those from ESABASE,although there are some minor errors mainly due to different debris data input.Through the cross-check by three risk assessment software-BUMPER,MDPANTO and MODAOST-under standard operating conditions,the feasibility of this method is again verified.

Computer Assisted Assignments of Rotationally Resolved Molecular Spectra

为旋转地解决的分子的系列的任务的一个图形地面向的交互节目被设计了。由组织的程序函数光谱以第二个差别原则，和 graphing 排队光谱在选择的组的一张工具条图的紧张对频率，由颜色或线类型区分了。这允许在观察光谱埋葬的常规模式的容易的察觉。而且，它为帮助在包括一个 LoomisWood 看法光谱任务。作为一个例子，节目在在氦气体缓冲的打印机控制语言 3 的分泌物分配生产的分子的光谱被使用，它可以属于几种。结果建议节目在任务和分子的系列的分析高度有效、相当有用，特别那些对称的最高的、稍微不对称的顶和线性分子。这个程序的精确性和效率将多半在处理分子的系列保证它的宽应用程序。