A retrospective clinical study of patients with pregnancy-associated breast cancer among multiple centers in China (CSBrS-008)

Background:Pregnancy-associated breast cancer(PABC)is a special type of breast cancer that occurs during pregnancy and within 1 year after childbirth.With the rapid social development and the adjustment of reproductive policies in China,the average age of females at first childbirth is increasing,which is expected to lead to an increase in the incidence of PABC.This study aimed to accumulate clinical experience and to investigate and summarize the prevalence,diagnosis,and treatment of PABC based on large multicenter samples in China.Methods:According to the Chinese Society of Breast Surgery,a total of 164 patients with PABC in 27 hospitals from January 2016 to December 2018 were identified.The pregnancy status,clinicopathological features,comprehensive treatment methods,and outcomes were retrospectively analyzed.Survival curves were plotted using the Kaplan-Meier method.Results:A total of 164 patients of PABC accounted for 0.30%of the total number of cases in the same period;of which,83 patients were diagnosed during pregnancy and 81 patients during lactation.The median age of PABC was 33 years(24–47 years).Stage Ⅰ patients accounted for 9.1%(15/164),stage Ⅱ 54.9%(90/164),stage Ⅲ 24.4%(40/164),and stage Ⅳ 2.4%(4/164).About 9.1%(15/164)of patients were luminal A.Luminal B patients accounted the most(43.3%[71/164]).About 15.2%(25/164)of patients were human epidermal growth factor receptor 2(Her-2)overexpression and 18.9%(31/164)of patients were triple-negative breast cancer.For pregnancy breast cancer,36.1%(30/83)of patients received direct surgery and 20.5%(17/83)received chemotherapy during pregnancy.About 31.3%(26/83)chose abortion or induction of labor.The median follow-up time was 36 months(3–59 months);11.0%(18/164)patients had local recurrence or distant metastasis and 3.0%(5/164)died.Conclusions:It is safe and feasible to standardize surgery and chemotherapy for PABC.

Microscopic Phase-Field Simulation for the Influence of Interatomic Potential on the Precipitation Process of Ni_(75)Al_(14)Mo_(11) Alloy

Abstract The process of γ＇ phase precipitating from Ni75Al14MO11 is studied by a computational simulation technique based on microscopic phase-field kinetics model. We studied the phase transformation with the purpose of clarifying the influence of the nearest interatomic potential V Ni-Al （the nearest interatomic potential） on the precipitation process of γ＇ phase. The result demonstrates that there are two kinds of ordered phases, respective Llo and L12 in the early stage, and Llo phase transforms into L12 phase subsequently. For L12 phase, Ni atoms mainly occupy α site （face center positions）, while Al and Mo atoms occupy fl sites （the vertex positions）. When VNi-Al is increased by 10 MeV, the occupation probability of Ni atoms on α sites and Al atoms on β sites are enhanced. Enhanced VNi-Al facilitates clustering and ordering of Al atom, which promotes the formation of the γ＇ phase. At last, the simulation result was discussed by employing the thermodynamic stability.

Phase-field simulation of tip splitting in dendritic growth of Fe-C alloy

Two types of dendrite tip splitting including dendrite orientation transition and twinned-like dendrites in Fe-C alloys were investigated by phase-field method. In equiaxed growth, the possible dendrite growth directions and the effect of supersaturation on tip splitting were discussed; the dendrite orientation transition was observed, and it was found that the orientation regions of anisotropy parameters were reduced from three to two with increasing the supersaturation, which was due to the effect of interracial anisotropy controlled by the solute in front of S/L interface changing with the increase of supersaturation. In directional solidification, it was found that the twinned like dendrites were formed with the fixed anisotropy couples and no seaweed dendrites were observed; these were concluded from the results of competition between process anisotropy and inherent anisotropy. The formation process of twinned-like dendrite was investigated by tip splitting phenomenon, which was related to the chan ges of dendrite tips growth velocity. Then, the critical speed of tips splitting and solute concentration of twinned-like dendrites were investigated, and a new type of microsegregation in Fe-C alloys was proposed to supplement the dendrite growth theories.