Sneddon's syndrome concurrent with cerebral venous sinus thrombosis:A case report

BACKGROUND This report delves into the diagnostic and therapeutic journey undertaken by a patient with Sneddon's syndrome(SS)and cerebral venous sinus thrombosis(CVST).Particular emphasis is placed on the comprehensive elucidation of SS's clinical manifestations,the intricate path to diagnosis,and the exploration of potential underlying mechanisms.CASE SUMMARY A 26-year-old woman presented with recurrent episodes of paroxysmal unilateral limb weakness accompanied by skin mottling,seizures,and cognitive impairment.Digital subtraction angiography revealed CVST.Despite negative antiphospholipid antibody results,skin biopsy indicated chronic inflammatory cell infiltration.The patient was treated using anticoagulation,antiepileptic therapy,and supportive care,which resulted in symptom improvement.The coexistence of SS and CVST is rare and the underlying pathophysiology remains uncertain.This case underscores the challenge in diagnosis and highlights the need for early clinical differentiation to facilitate accurate assessment and prompt intervention.CONCLUSION This article has reported and analyzed the clinical data,diagnosis,treatment,and prognosis of a case of SS with CVST and reviewed the relevant literature to improve the clinical understanding of this rare condition.

Effects of Calcium Ions on Thermodynamic Properties of Mixed Bilirubin/Cholesterol Monolayers

bilirubin/cholesterol 的混合单层行为通过表面压力区域被学习(包含钙离子的各种各样的集中的水的溶液上的 -A) 等温线。把等温线基于 A 的数据，吝啬的区域每分子，倒塌压力，表面压缩的可能性模量，分子的区域，混合的免费精力，和过量释放的过量在不同 subphases 上单层混合的精力被计算。结果证明在有在 subphase 的 Ca2+ 的混合单层的结构的扩大，并且在空气 / 水接口的部件的非理想的混合在过量从添加规则与积极偏差被观察分子的区域。在部件之间的可混和性随 subphase 的 Ca2+ 的集中的增加被削弱。事实显示在 Ca2+ 和二个部件之间的协作的存在。混合单层，到胆固醇的 bilirubin 的臼齿的比率在是 3:2，从纯水上的一个热力学的观点是更稳定的。但是稳定的 3:2 stoichiometry 建筑群随 subphase 的 Ca2+ 的集中的增加被破坏。否则，混合单层在 Ca2+ subphase 上在更低的表面压力有更多的热力学的稳定性。

Leptin enhances the release of cytokines by peripheral blood mononuclear cells from acute multiple sclerosis patients

Objective To explore the effect of leptin on cytokine production by PBMCs obtained from MS patients either in acute （relapse） or in stable （nonrelapse） phase of disease. Methods PBMCs were collected from 25 untreated acute MS patients, 11 stable MS patients and 20 healthy controls. PBMCs were cultured either with RPMI-1640 alone or with leptin （ 1.25 nmol/ml）, phytohemagglutinin （PHA） （ 100 μg/ml）, and leptin ＋ PHA. 72 h later the supemate of the culture medium were collected and stored at -70℃. The pro-inflammatory cytokine （IFN-γ） concentration were determined using an enzyme-linked immunosorbent assay （ELISA）, and the anti-inflammatory cytokine （IL-4） concentration were investigated by radioimmunity methods. Results Our data showed that leptin induced IFN-γ production by PBMCs of patients in an acute phase of disease but not in a stable phase or in healthy controls. Moreover, we found that PHA induced IL-4 production by PBMCs of patients in an acute phase of disease, but leptin inhibited this ability of PHA. Conelusion Leptin can affect on pro- and anti-inflammatory cytokine production by PBMCs collected from MS patients, may be this connected with leptln increase the susceptiveness of MS.

Guillain-Barrésyndrome and hemophagocytic syndrome heralding the diagnosis of diffuse large B cell lymphoma:A case report

BACKGROUND Central nervous system(CNS)lesions and peripheral neuropathy are rare among patients with non-Hodgkin’s lymphoma(NHL).Lymphomatous infiltration or local oppression usually accounts for CNS or peripheral nerve lesions.The incidence of peripheral neuropathy was 5%.Guillain-Barrésyndrome(GBS)is rare and may occur in less than 0.3%of patients with NHL.Hemophagocytic syndrome(HPS)is a rare complication of NHL.It has been reported that 1%of patients with hematological malignancies develop HPS.Diffuse large B-cell lymphoma(DLBCL)combined with GBS has been reported in 10 cases.CASE SUMMARY We report the case of a 53-year-old man who was initially hospitalized because of abnormal feelings in the lower limbs and urinary incontinence.He was finally diagnosed with DLBCL combined with GBS and HPS after 16 d,which was earlier than previously reported.Immunoglobulin pulse therapy,dexamethasone,and etoposide were immediately administered.The neurological symptoms did not improve,but cytopenia was relieved.However,GBS-related clinical symptoms were relieved partially after one cycle of rituximab-cyclophosphamide,hydroxydaunorubicin,vincristine,and prednisone(R-CHOP)chemotherapy and disappeared after six cycles of R-CHOP.CONCLUSION GBS and HPS heralding the diagnosis of Epstein-Barr virus DLBCL are rare.Herein,we report a rare case of DLBCL combined with GBS and HPS,and share our clinical experience.Traditional therapies may be effective if GBS occurs before lymphoma is diagnosed.Rapid diagnosis and treatment of DLBCL are crucial.

In situ sol-gel synthesis of Ti2Nb10O29/C nanoparticles with enhanced pseudocapacitive contribution for a high-rate lithium-ion battery

Ti2Nb10O29/C nanoparticles with a carbon content of 13 wt%and a mean size of 50 nm were fabricated through a convenient and effective in situ sol-gel process.The small grain size and carbon modification can improve the pseudocapacitive effect of the Ti2Nb10O29/C nanoparticles,leading to excellent rate capacity,especially at high current rate.Specifically,the discharge capacity of the Ti2Nb10O29/C electrode is 258.3,236.0,216.6,184.5 and161.5 mAh·g-1 at different current densities of 1C,5C,10C,20C and 30C.Nevertheless,the discharge capacity of the Ti2Nb10O29 electrode is 244.9 mAh·g-1 at 1C,which is rapidly reduced to 89.7 mAh·g-1 at 30C.In addition,the small size and carbon layer of the Ti2Nb10O29/C nanoparticles can supply abundant active sites for Li+storage as well as enhance the electronic conductivity and Li+diffusion,endowing these nanoparticles with a high discharge capacity and excellent cycle performance.

In Vivo Degradation Behavior of Porous Composite Scaffolds of Poly(lactide-co-glycolide) and Nano-hydroxyapatite Surface Grafted with Poly(L-lactide)

The biodegradable porous composite scaffold, composed of poly（lactide-co-glycolide） （PLGA） and hydroxyapatite nanoparticles （n-HAP） surface-grafted with poly（L-lactide） （PLLA） （g-HAP） （g-HAP/PLGA）, was fabricated using the solvent casting/particulate leaching method, and its in vivo degradation behavior was investigated by the intramuscular implantation in rabbits. The composite of un-grafted n-HAP/PLGA and neat PLGA were used as controls. The scaffolds had interconnected pore structures with average pore sizes between 137 μm and 148 μm and porosities between 83% and 86%. There was no significant difference in the pore size and porosity among the three scaffolds. Compared with n-HAP/PLGA, the thermo-degradation temperature （Tc） of g-HAP/PLGA decreased while its glass transition temperature （Tg） increased. The weight change, grey value analysis of radiographs and SEM observation showed that the composite scaffolds of g-HAP/PLGA and n-HAP/PLGA showed slower degradation and higher mineralization than the pure PLGA scaffold after the intramuscular implantation. The rapid degradation of PLGA, g-HAP/PLGA and n-HAP/PLGA occurred at 8-12 weeks, 12-16 weeks and 16-20 weeks, respectively. Compared with n-HAP/PLGA, g-HAP/PLGA showed an improved absorption and biomineralization property mostly because of its improved distribution of HAP nanoparticles. The levels of both calcium and phosphorous in serum and urine could be affected to some extent at 3-4 weeks after the implantation of g-HAP/PLGA, but the biochemical detection of serum AST, ALT, ALP, and GGT as well as BUN and CRE showed no obvious influence on the functions of liver and kidney.