With the increasingly widespread application of traditional Chinese medicine in clinical practice,the safety of traditional Chinese medicine has been given more attention.The occurrence of adverse drug reactions of tr...With the increasingly widespread application of traditional Chinese medicine in clinical practice,the safety of traditional Chinese medicine has been given more attention.The occurrence of adverse drug reactions of traditional Chinese medicine will harm the health of patients,leading to a certain incidence rate and mortality rate,and serious adverse drug reactions of traditional Chinese medicine will lead to increased treatment costs of patients,bringing huge economic burden to patients and society[1-3].展开更多
BACKGROUND:Few studies investigated serum uric acid levels in patients with acute STelevation myocardial infarction(STEMI).The study was to assess the clinical value of serum uric acid levels in patients with acute ST...BACKGROUND:Few studies investigated serum uric acid levels in patients with acute STelevation myocardial infarction(STEMI).The study was to assess the clinical value of serum uric acid levels in patients with acute ST-elevation myocardial infarction(STEMI).METHODS:Totally 502 consecutive patients with STEMI were retrospectively studied from January 2005 to December 2010.The level of serum lipid,echocardiographic data and in-hospital major adverse cardiovascular events(MACE) in patients with hyperuricemia(n=119) were compared with those in patients without hyperuricemia(n=383).The relationship between the level of serum uric acid and the degree of diseased coronary artery was analyzed.All data were analyzed with SPSS version 17.0 software for Student's t test,the Chi-square test and Pearson's correlation coefficient analysis.RESULTS:Serum uric acid level was positively correlated with serum triglyceride level.Hyperlipidemia was more common in hyperuricemia patients than in non-hyperuricemia patients(43.7%vs.33.7%,P=0.047),and serum triglyceride level was significantly higher in hyperuricemia patients(2.11±1.24 vs.1.78±1.38,P=0.014).But no significant association was observed between serum uric acid level and one or more diseased vessels(P>0.05).Left ventricular end-diastolic diameter(LVEDd) was larger in hyperuricemia patients than in non-hyperuricemia patients(53.52±6.19 vs.52.18±4.89,P=0.041).The higher rate of left systolic dysfunction and diastolic dysfunction was discovered in hyperuricemia patients(36.4%vs.15.1%,P<0.001;68.2%vs.55.8%,P=0.023).Also,hyperuricemia patients were more likely to have in-hospital MACE(P<0.05).CONCLUSIONS:Serum uric acid level is positively correlated with serum triglyceride level,but not with the severity of coronary artery disease.Hyperuricemia patients with STEMI tend to have a higher rate of left systolic dysfunction and diastolic dysfunction and more likely to have more in-hospital MACE.展开更多
Weak signal detection has become an important means of mechanical fault detections. In order to solve the problem of poor signal detection performance in classical tristable stochastic resonance system(CTSR), a novel ...Weak signal detection has become an important means of mechanical fault detections. In order to solve the problem of poor signal detection performance in classical tristable stochastic resonance system(CTSR), a novel unsaturated piecewise linear symmetric tristable stochastic resonance system(PLSTSR) is proposed. Firstly, by making the analysis and comparison of the output and input relationship between CTSR and PLSTSR, it is verified that the PLSTSR has good unsaturation characteristics. Then, on the basis of adiabatic approximation theory, the Kramers escape rate, the mean first-passage time(MFPT), and output signal-to-noise ratio(SNR) of PLSTSR are deduced, and the influences of different system parameters on them are studied. Combined with the adaptive genetic algorithm to synergistically optimize the system parameters, the PLSTSR and CTSR are used for numerically simulating the verification and detection of low-frequency, high-frequency,and multi-frequency signals. And the results show that the SNR and output amplitude of the PLSTSR are greatly improved compared with those of the CTSR, and the detection effect is better. Finally, the PLSTSR and CTSR are applied to the bearing fault detection under Gaussian white noise and Levy noise. The experimental results also show that the PLSTSR can obtain larger output amplitude and SNR, and can detect fault signals more easily, which proves that the system has better performance than other systems in bearing fault detection, and has good theoretical significance and practical value.展开更多
Background:The detrimental outcomes of right ventricular pacing on left ventricular electromechanical function ultimately result in heart failure,a phenomenon termed pacing-induced cardiomyopathy(PICM)in clinical rese...Background:The detrimental outcomes of right ventricular pacing on left ventricular electromechanical function ultimately result in heart failure,a phenomenon termed pacing-induced cardiomyopathy(PICM)in clinical research.This study aimed to validate prognostic factors that can be used to identify patients with higher susceptibility to progress to the stage of cardiomyopathy before pacemaker implantation.Methods:This observational analysis enrolled 256 patients between January 2013 and June 2016,23(8.98%)of whom progressed to PICM after 1 year of follow-up.A Cox proportional hazard model was used to analyze the prognostic factors associated with PICM.Dose-response analysis was used to evaluate the relationship between significant indicators in multifactor analysis and PICM.Results:The mean values of left ventricular ejection fraction before and after pacemaker implantation in 23 patients diagnosed with PICM were 62.3%and 42.7%,respectively.Univariate analysis showed that sex,atrio-ventricular block,paced QRS duration,and ventricular pacing percentage were significantly associated with PICM.In the multivariate analysis,male sex(hazard ratio:1.20,95%confidence interval[CI]:1.09-1.33,P<0.005),paced QRS duration(hazard ratio:1.95 per 1 ms increase,95%CI:1.80-2.12,P<0.001),and ventricular pacing percentage(hazard ratio:1.65 per 1%increase,95%CI:1.51-1.79,P<0.001)were independent prognostic factors associated with the development of PICM.The ventricular pacing percentage and paced QRS duration level defined by the dose-response analysis were positively associated with PICM(P<0.05).Conclusions:Our findings indicated that paced QRS duration and ventricular pacing percentage were the most sensitive prognostic factors for PICM.展开更多
文摘With the increasingly widespread application of traditional Chinese medicine in clinical practice,the safety of traditional Chinese medicine has been given more attention.The occurrence of adverse drug reactions of traditional Chinese medicine will harm the health of patients,leading to a certain incidence rate and mortality rate,and serious adverse drug reactions of traditional Chinese medicine will lead to increased treatment costs of patients,bringing huge economic burden to patients and society[1-3].
文摘BACKGROUND:Few studies investigated serum uric acid levels in patients with acute STelevation myocardial infarction(STEMI).The study was to assess the clinical value of serum uric acid levels in patients with acute ST-elevation myocardial infarction(STEMI).METHODS:Totally 502 consecutive patients with STEMI were retrospectively studied from January 2005 to December 2010.The level of serum lipid,echocardiographic data and in-hospital major adverse cardiovascular events(MACE) in patients with hyperuricemia(n=119) were compared with those in patients without hyperuricemia(n=383).The relationship between the level of serum uric acid and the degree of diseased coronary artery was analyzed.All data were analyzed with SPSS version 17.0 software for Student's t test,the Chi-square test and Pearson's correlation coefficient analysis.RESULTS:Serum uric acid level was positively correlated with serum triglyceride level.Hyperlipidemia was more common in hyperuricemia patients than in non-hyperuricemia patients(43.7%vs.33.7%,P=0.047),and serum triglyceride level was significantly higher in hyperuricemia patients(2.11±1.24 vs.1.78±1.38,P=0.014).But no significant association was observed between serum uric acid level and one or more diseased vessels(P>0.05).Left ventricular end-diastolic diameter(LVEDd) was larger in hyperuricemia patients than in non-hyperuricemia patients(53.52±6.19 vs.52.18±4.89,P=0.041).The higher rate of left systolic dysfunction and diastolic dysfunction was discovered in hyperuricemia patients(36.4%vs.15.1%,P<0.001;68.2%vs.55.8%,P=0.023).Also,hyperuricemia patients were more likely to have in-hospital MACE(P<0.05).CONCLUSIONS:Serum uric acid level is positively correlated with serum triglyceride level,but not with the severity of coronary artery disease.Hyperuricemia patients with STEMI tend to have a higher rate of left systolic dysfunction and diastolic dysfunction and more likely to have more in-hospital MACE.
基金Project supported by the National Natural Science Foundation of China(Grant No.61771085)the Research Project of Chongqing Educational Commission,China(Grant Nos.KJ1600407 and KJQN201900601)the Natural Science Foundation of Chongqing,China(Grant No.cstc2021jcyj-msxm X0836)。
文摘Weak signal detection has become an important means of mechanical fault detections. In order to solve the problem of poor signal detection performance in classical tristable stochastic resonance system(CTSR), a novel unsaturated piecewise linear symmetric tristable stochastic resonance system(PLSTSR) is proposed. Firstly, by making the analysis and comparison of the output and input relationship between CTSR and PLSTSR, it is verified that the PLSTSR has good unsaturation characteristics. Then, on the basis of adiabatic approximation theory, the Kramers escape rate, the mean first-passage time(MFPT), and output signal-to-noise ratio(SNR) of PLSTSR are deduced, and the influences of different system parameters on them are studied. Combined with the adaptive genetic algorithm to synergistically optimize the system parameters, the PLSTSR and CTSR are used for numerically simulating the verification and detection of low-frequency, high-frequency,and multi-frequency signals. And the results show that the SNR and output amplitude of the PLSTSR are greatly improved compared with those of the CTSR, and the detection effect is better. Finally, the PLSTSR and CTSR are applied to the bearing fault detection under Gaussian white noise and Levy noise. The experimental results also show that the PLSTSR can obtain larger output amplitude and SNR, and can detect fault signals more easily, which proves that the system has better performance than other systems in bearing fault detection, and has good theoretical significance and practical value.
文摘Background:The detrimental outcomes of right ventricular pacing on left ventricular electromechanical function ultimately result in heart failure,a phenomenon termed pacing-induced cardiomyopathy(PICM)in clinical research.This study aimed to validate prognostic factors that can be used to identify patients with higher susceptibility to progress to the stage of cardiomyopathy before pacemaker implantation.Methods:This observational analysis enrolled 256 patients between January 2013 and June 2016,23(8.98%)of whom progressed to PICM after 1 year of follow-up.A Cox proportional hazard model was used to analyze the prognostic factors associated with PICM.Dose-response analysis was used to evaluate the relationship between significant indicators in multifactor analysis and PICM.Results:The mean values of left ventricular ejection fraction before and after pacemaker implantation in 23 patients diagnosed with PICM were 62.3%and 42.7%,respectively.Univariate analysis showed that sex,atrio-ventricular block,paced QRS duration,and ventricular pacing percentage were significantly associated with PICM.In the multivariate analysis,male sex(hazard ratio:1.20,95%confidence interval[CI]:1.09-1.33,P<0.005),paced QRS duration(hazard ratio:1.95 per 1 ms increase,95%CI:1.80-2.12,P<0.001),and ventricular pacing percentage(hazard ratio:1.65 per 1%increase,95%CI:1.51-1.79,P<0.001)were independent prognostic factors associated with the development of PICM.The ventricular pacing percentage and paced QRS duration level defined by the dose-response analysis were positively associated with PICM(P<0.05).Conclusions:Our findings indicated that paced QRS duration and ventricular pacing percentage were the most sensitive prognostic factors for PICM.
