A series of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives were designed and synthesized.Their structures were confirmed by melting points, IR,1H NMR,13 C NMR, and HRMS or elemental analysis. Biological acti...A series of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives were designed and synthesized.Their structures were confirmed by melting points, IR,1H NMR,13 C NMR, and HRMS or elemental analysis. Biological activities of all title compounds including fungicidal activity and antivirus activity were evaluated systematically. Preliminary bioassays indicated that these compounds exhibited good fungicidal activity at 50 mg/m L, compounds 4b and 4i exhibited over 50% activity against six fungi tested.Most compounds showed good activity against TMV with different models in vivo at 100 mg/m L.Compounds 4c and 4e stood out with high effects against TMV in vivo in all models tested, including protective, inactivative, curative, and inductive activities. These data demonstrate a new strategy for fungi and virus control.展开更多
Since its inception,the full Lagrangian meshless smoothed particle hydrodynamics(SPH)has experienced a tremendous enhancement in methodology and impacted a range of multi-physics applications in science and engineerin...Since its inception,the full Lagrangian meshless smoothed particle hydrodynamics(SPH)has experienced a tremendous enhancement in methodology and impacted a range of multi-physics applications in science and engineering.This review presents a concise survey on latest developments and achievements of the SPH method,including:(1)Brief review of theory and fundamental with kernel corrections,(2)The Riemann-based SPH method with dissipation limiting and high-order data reconstruction by using MUSCL,WENO and MOOD schemes,(3)Particle neighbor searching with particle sorting and efficient dual-criteria time stepping schemes,(4)Total Lagrangian formulation with stablized,dynamics relaxation and hourglass control schemes,(5)Fluid-structure interaction scheme with interface treatments and multi-resolution discretizations,(6)Novel applications of particle relaxation in SPH methodology for mesh and particle generations.Last but not least,benchmark tests for validating computational accuracy,convergence,robustness and efficiency are also supplied accordingly.展开更多
基金supported by The International Science & Technology Cooperation Program of China (No.2014DFR41030)Nataliya P. Belskaya thanks Russian State Task of Ministry Education and Science (No.4.560.2014/K )Kalinina Tatiana thanks RFBF (No.13-03-00137)
文摘A series of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives were designed and synthesized.Their structures were confirmed by melting points, IR,1H NMR,13 C NMR, and HRMS or elemental analysis. Biological activities of all title compounds including fungicidal activity and antivirus activity were evaluated systematically. Preliminary bioassays indicated that these compounds exhibited good fungicidal activity at 50 mg/m L, compounds 4b and 4i exhibited over 50% activity against six fungi tested.Most compounds showed good activity against TMV with different models in vivo at 100 mg/m L.Compounds 4c and 4e stood out with high effects against TMV in vivo in all models tested, including protective, inactivative, curative, and inductive activities. These data demonstrate a new strategy for fungi and virus control.
基金This work was supported by the Deutsche Forschungsgemeinschaft(DFG)(Grant No.HU1527/12-4)。
文摘Since its inception,the full Lagrangian meshless smoothed particle hydrodynamics(SPH)has experienced a tremendous enhancement in methodology and impacted a range of multi-physics applications in science and engineering.This review presents a concise survey on latest developments and achievements of the SPH method,including:(1)Brief review of theory and fundamental with kernel corrections,(2)The Riemann-based SPH method with dissipation limiting and high-order data reconstruction by using MUSCL,WENO and MOOD schemes,(3)Particle neighbor searching with particle sorting and efficient dual-criteria time stepping schemes,(4)Total Lagrangian formulation with stablized,dynamics relaxation and hourglass control schemes,(5)Fluid-structure interaction scheme with interface treatments and multi-resolution discretizations,(6)Novel applications of particle relaxation in SPH methodology for mesh and particle generations.Last but not least,benchmark tests for validating computational accuracy,convergence,robustness and efficiency are also supplied accordingly.
