Objective:Thrombosis in patients with atrial arrhythmias might be associated with remodeling of the left atrium(LA).We aimed to describe this relationship and identify a novel factor,in addition to the CHA_(2)DS_(2)-V...Objective:Thrombosis in patients with atrial arrhythmias might be associated with remodeling of the left atrium(LA).We aimed to describe this relationship and identify a novel factor,in addition to the CHA_(2)DS_(2)-VASc score,to guide therapeutic strategies for preventing thromboembolism in the hope of improving the prognosis for such patients.Methods:Patients diagnosed with atrial arrhythmias and who met our inclusion criteria were enrolled in this study.Various clinical parameters were recorded;diameters reflecting remodeling of the LA were measured and thrombosis was diagnosed by enhanced CT.Results:Totally,192 patients were enrolled in the study.The overall prevalence of left atrial thrombosis was 8.3%.Patients with persistent atrial fibrillation exhibited the highest anteroposterior diameter of the LA(45.1±7.2 mm)and prevalence of thrombosis(15.6%).An anteroposterior LA diameter of≥50 mm was a strong independent impact risk factor for thrombosis(OR=10.1,95%CI:2.8-36.9,P<0.OO1).The prevalence of LA thrombosis in patients with and without anteroposterior LA diameter of≥50 mm was 25.8%and 5.0%,respectively.Conclusion:Marked remodeling of the LA characterized by an anteroposterior LA diameter of≥50 mm is a strong independent risk factor of thrombosis,and should be considered for the prevention of thromboembolism through various strategies.展开更多
Physiological and genetic variations exist richly in the cotton plants regenerated from somatic embryo. A stable homeotic variant (chv1) of cotton from regenerated plants was identified.Using light microscope and ... Physiological and genetic variations exist richly in the cotton plants regenerated from somatic embryo. A stable homeotic variant (chv1) of cotton from regenerated plants was identified.Using light microscope and scanning electron microscope to investigate the morphological changes in chv1, the results revealed that all the floral organs in the chvl1 plants converted into leaves, meanwhile the placenta and ovules bearing on the basal part in central leaf-like organs can be discerned.
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As a strategy for phytopathogen control through transgenic way, antimicrobial peptide genes have been employed over the last two decades.CEMA is a cationic antimicrobial chimeric peptide, which is produced by fusi... As a strategy for phytopathogen control through transgenic way, antimicrobial peptide genes have been employed over the last two decades.CEMA is a cationic antimicrobial chimeric peptide, which is produced by fusing eight amino acid residues from the antimicrobial peptide ceropin A with a modified meltin. Three transgenic cotton plants were generated by bombardment of cotton shoot tips using BioRad particle gun. The gold particles were coated with a cationic peptide, CEMA, DNA.
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基金supported by Yunnan Applied Basic Research Projects(Kunming Medical University Union Special Fund)[No.2018FE001(-154)]Yunnan Provincial Fund for High Level Reserve Talents in Health Science(No.H-2018037)+2 种基金Scientific Research Fund Project of Fuwai Yunnan Cardiovascular Hospital(No.2019YFKT-04)Young Scientists Fund(No.81501406)Yunnan Provincial Fund for High Level Reserve Talents in Health Science(No.H-2017068).
文摘Objective:Thrombosis in patients with atrial arrhythmias might be associated with remodeling of the left atrium(LA).We aimed to describe this relationship and identify a novel factor,in addition to the CHA_(2)DS_(2)-VASc score,to guide therapeutic strategies for preventing thromboembolism in the hope of improving the prognosis for such patients.Methods:Patients diagnosed with atrial arrhythmias and who met our inclusion criteria were enrolled in this study.Various clinical parameters were recorded;diameters reflecting remodeling of the LA were measured and thrombosis was diagnosed by enhanced CT.Results:Totally,192 patients were enrolled in the study.The overall prevalence of left atrial thrombosis was 8.3%.Patients with persistent atrial fibrillation exhibited the highest anteroposterior diameter of the LA(45.1±7.2 mm)and prevalence of thrombosis(15.6%).An anteroposterior LA diameter of≥50 mm was a strong independent impact risk factor for thrombosis(OR=10.1,95%CI:2.8-36.9,P<0.OO1).The prevalence of LA thrombosis in patients with and without anteroposterior LA diameter of≥50 mm was 25.8%and 5.0%,respectively.Conclusion:Marked remodeling of the LA characterized by an anteroposterior LA diameter of≥50 mm is a strong independent risk factor of thrombosis,and should be considered for the prevention of thromboembolism through various strategies.
文摘 Physiological and genetic variations exist richly in the cotton plants regenerated from somatic embryo. A stable homeotic variant (chv1) of cotton from regenerated plants was identified.Using light microscope and scanning electron microscope to investigate the morphological changes in chv1, the results revealed that all the floral organs in the chvl1 plants converted into leaves, meanwhile the placenta and ovules bearing on the basal part in central leaf-like organs can be discerned.
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文摘 As a strategy for phytopathogen control through transgenic way, antimicrobial peptide genes have been employed over the last two decades.CEMA is a cationic antimicrobial chimeric peptide, which is produced by fusing eight amino acid residues from the antimicrobial peptide ceropin A with a modified meltin. Three transgenic cotton plants were generated by bombardment of cotton shoot tips using BioRad particle gun. The gold particles were coated with a cationic peptide, CEMA, DNA.
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