NEW PARAMETER FOR DESCRIBING AND ANALYZING THE OPTICAL-ANISOTROPIC PROPERTIES OF BIOLOGICAL TISSUES

To characterize the degree of similarity inherent to parameters of the optically uniaxial birefringent protein-fibril networks of biological tissues,a new parameter-complex degree of mutual anisotropy-has been offered.The technique of polarization measuring the coordinate distributions of the complex degree of mutual anisotropy of biological tissues has been developed.It has been shown that statistical approach to the analysis of complex degree of mutual anisotropy distributions for biological tissues in various morphological and physiological states and for different optical thicknesses appears to be more sensitive and efficient in differentiation of physiological state,as compared to investigations of complex degree of mutual polarization in the corresponding laser images.

THE FEASIBILITIES OF USING THE STATISTICAL,FRACTAL AND SINGULAR PROCESSING OF HOMINAL BLOOD PLASMA PHASE IMAGES DURING THE DIAGNOSTICS AND DIFFERENTIATION OF MAMMARY GLAND PATHOLOGICAL STATES

Performed in this work are complex statistical,fractal and singular analyses of phase properties inherent to birefringence networks of protein crystals consisting of optically-thin layers prepared from blood plasma.Within the framework of a statistical approach,the authors have investigated values and ranges for changes of statistical moments of thefirst to the fourth orders that characterize coordinate distributions for phase shifts between orthogonal components of amplitudes inherent to laser radiation transformed by blood plasma with various pathologies.In the framework of the fractal approach,determined are the dimensions of self-similar coordinate phase distributions as well as features of transformation of logarithmic dependences for power spectra of these distributions for various types of hominal mammary gland pathologies.

Laser polarization-variable autofluorescence of the network of optically anisotropic biological tissues:Diagnostics and differentiation of early stages of cancer of cervia uteri

This research presents the results of investigation of laser_polarization fluorescence ofbiological layers(histological sections,cy tological smears)in the task of diagnostics and differ-en tiation of early stages of cancer:Dysplasia-cervical microinvasive carcinoma of cervic uteri.The analytical conditions of polarization-optimal probing of biological layers were determinedbasing on the model of linear birefringence and dichroism of birefringent(fibrllar,porphyrin)networks.The technique of polarization-variable laser autofluorescence was developed andexperimentally tested.The objective criteria(statistical moments)of differentiation of histo-logical sections autofluorescent images of endometrium biopsy and cytological smears of itmucous coat were defined.The operational characteristics(sensitivity,speifity,accuracy)ofthis technique were determined concerning the positions of probative medicine,and clinical efficiency.

Biomedical applications of Jones-matrix tomography to polycrystalline films of biological fuids

Algorithms for reconstruction of linear and circular birefringence-dichroism of optically thin anisotropic biological layers are presented.The technique of Jones matrix tomography of poly-crystalline films of biological fuids of various human organs has been developed and experimentally tested.The coordinate distributions of phase and amplitude anisotropy of bile films and synovial fuid taken from the knee joint are determined and statistically analyzed.Criteria(statistical moments of 3rd and 4th orders)of differential diagnostics of early stages of cholelithiasis and septic arthritis of the knee joint with excellent balanced accuracy were determined.Data on the diagnostic fficiency of the Jones matrix tomography method for polyerystalline plasma(liver disease),urine(albuminuria)and cytological smears(cervical cancer)are presented.

CLASSIFYING OPTICAL PROPERTIES OF SURFACE-AND BULK-SCATTERING BIOLOGICAL LAYERS WITH POLARIZATION SINGULAR STATES

The results of singular approach usage in the tasks of description and classification of appearance of optical anisotropy of different types of phase-inhomogeneous biological layers(surface-scattering,optically thin and optically thick)have been presented.The characteristic values of the fourth Stokes vector parameter(S_(4)=0-linear polarization-(L-state);S_(4)=±1-circular polarization-(C-state))have been chosen as the main analytical tool descni bing polarization-singular states.The value of S.has been deternined by the value of phase shift betwoen the ort hogonal components of amplitude in the point of biological layer laser image and therefore is azimuthally stable.Hence,statistic moments of the first to the fourth orders characterizing the distribution of the amount of characteristic values S4=0;S_(4)=±1 have been used for definition and di ferentiation of optical properties of diferent types of biological layers-surface scattering,optically thin and optically thick human skin.