Sharp corners usually are used on glass contours to meet the highly increasing demand for personalized products,but they result in a broken wheel center toolpath in edge grinding.To ensure that the whole wheel center ...Sharp corners usually are used on glass contours to meet the highly increasing demand for personalized products,but they result in a broken wheel center toolpath in edge grinding.To ensure that the whole wheel center toolpath is of G1 continuity and that the grinding depth is controllable at the corners,a transition toolpath generation method based on a velocity-blending algorithm is proposed.Taking the grinding depth into consideration,the sharp-corner grinding process is planned,and a velocity-blending algorithm is introduced.With the constraints,such as traverse displacement and grinding depth,the sharp-corner transition toolpath is generated with a three-phase motion arrangement and with confirmations of the acceleration/deceleration positions.A piece of glass with three sharp corners is ground on a three-axis numerical-control glass grinding equipment.The experimental results demonstrate that the proposed algorithm can protect the sharp corners from breakage efficiently and achieve satisfactory shape accuracy.This research proposed a toolpath generation method based on a velocity-blending algorithm for the manufacturing of personalized glass products,which generates the transition toolpath as needed around a sharp corner in real time.展开更多
A new optical system for an augmented reality(AR) display is proposed in this paper.The optical system mainly includes a ray deflector, coupling input grating, optical waveguide, and coupling output grating.Both the r...A new optical system for an augmented reality(AR) display is proposed in this paper.The optical system mainly includes a ray deflector, coupling input grating, optical waveguide, and coupling output grating.Both the ray deflector and the coupling input grating are designed based on the diffraction characteristics of the polarization grating, and the coupling output grating is the Bragg reflection grating.Compared with other AR schemes, this AR optical system not only reduces the number of projections from two to one, but also improves the efficiency of light coupling into the optical waveguides.The energy loss is reduced by utilizing the single-order diffraction characteristics of the polarization grating in its coupling input structure.The light deflector uses the polarization selectivity of the polarization grating and the characteristics of the rotating light of the twisted nematic liquid crystal layer to realize beam deflection.The working principle of the optical system is experimentally and theoretically demonstrated.展开更多
Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation o...Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner.展开更多
In this Letter, an all-optical logic sequence generator based on two different polarization holographic gratings has been proposed and demonstrated, which has one input port and four output ports. The polarization sta...In this Letter, an all-optical logic sequence generator based on two different polarization holographic gratings has been proposed and demonstrated, which has one input port and four output ports. The polarization state of input light signal determines logic output signals. It can produce four kinds of logic sequence output signals:1000, 0100, 0010, and 0001, corresponding to the input light signal of four different polarization states: the p-linear, s-linear, left-handed circular, and right-handed circular. The two polarization gratings have been fabricated, and the working principle of the logic sequence generator has been proved by diffraction pattern analysis of polarization gratings.展开更多
基金Supported by National Key R&D Program of China(Grant No.2017YFB0309800)National Natural Science Foundation of China(Grant No.51405445)
文摘Sharp corners usually are used on glass contours to meet the highly increasing demand for personalized products,but they result in a broken wheel center toolpath in edge grinding.To ensure that the whole wheel center toolpath is of G1 continuity and that the grinding depth is controllable at the corners,a transition toolpath generation method based on a velocity-blending algorithm is proposed.Taking the grinding depth into consideration,the sharp-corner grinding process is planned,and a velocity-blending algorithm is introduced.With the constraints,such as traverse displacement and grinding depth,the sharp-corner transition toolpath is generated with a three-phase motion arrangement and with confirmations of the acceleration/deceleration positions.A piece of glass with three sharp corners is ground on a three-axis numerical-control glass grinding equipment.The experimental results demonstrate that the proposed algorithm can protect the sharp corners from breakage efficiently and achieve satisfactory shape accuracy.This research proposed a toolpath generation method based on a velocity-blending algorithm for the manufacturing of personalized glass products,which generates the transition toolpath as needed around a sharp corner in real time.
基金Project supported by the National Natural Science Foundation of China(Grant No.11574211)
文摘A new optical system for an augmented reality(AR) display is proposed in this paper.The optical system mainly includes a ray deflector, coupling input grating, optical waveguide, and coupling output grating.Both the ray deflector and the coupling input grating are designed based on the diffraction characteristics of the polarization grating, and the coupling output grating is the Bragg reflection grating.Compared with other AR schemes, this AR optical system not only reduces the number of projections from two to one, but also improves the efficiency of light coupling into the optical waveguides.The energy loss is reduced by utilizing the single-order diffraction characteristics of the polarization grating in its coupling input structure.The light deflector uses the polarization selectivity of the polarization grating and the characteristics of the rotating light of the twisted nematic liquid crystal layer to realize beam deflection.The working principle of the optical system is experimentally and theoretically demonstrated.
基金We thank Quentin Liu’s lab members for their critical comments and technical support.We thank Eric W.-F.Lam for his critical reading of the manuscript and insightful suggestions.This research work was supported by the National Natural Science Foundation of China(No.81820108024 to Q.L.,No.81630005 to Q.L.,No.81830088 to Y.W.,No.81873441 to B.-L.J.,No.82103659 to S.-S.L.,No.8210113819 to Y.-F.Q.,No.81972786 to J.X.,No.82003141 to F.P.,No.82002960 to B.C.,No.31801100 to X.-.D.D.)National Key R&D Program of China(2019YFA0110300 to Q.L.and 2017YFA0505600-04 to Q.L.)+12 种基金Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China(No.IRT_17R15)Innovative Research Team in University of Liaoning(No.LT2017001 to Q.L.)Heilongjiang Postdoctoral Fund(No.LBH-Z20074 to S.-S.L.)Harbin Medical University Doctor Green Seedling Ground-breaking Project(No.QMPT-1909 to S.-S.L.)the Natural Science Foundation of Liaoning(No.2019-BS-081 to F.P.)the“Seedling cultivation”program for young scientific and technological talents of Liaoning(No.LZ2020044 to F.P.,No.LZ2019067 to B.C.)Dalian Science and Technology program-The central government guiding local funding projects for scientific and technological development(2021 to F.P.)Dalian High-level Talents Innovation Support Program-Young Science and Technology Star(2021RQ004 to B.C.)the program for climbing Scholars of Liaoning,the Science and Technology Innovation Foundation of Dalian(No.2020JJ25CY008 to Q.L.)International Scientific and Technological Cooperation of Dalian(2015F11GH095 to Q.L.)the Natural Science Foundation of Guangdong(2016A030311038 and 2017A030313608 to Q.L.)the Science and Technology Planning Project of Guangzhou(No.201804020044 to Q.L.)the Scientific Research Project of Guangzhou(No.201904010492 to B.-L.J.).
文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner.
基金supported by the National Natural Science Foundation of China(No.11574211)
文摘In this Letter, an all-optical logic sequence generator based on two different polarization holographic gratings has been proposed and demonstrated, which has one input port and four output ports. The polarization state of input light signal determines logic output signals. It can produce four kinds of logic sequence output signals:1000, 0100, 0010, and 0001, corresponding to the input light signal of four different polarization states: the p-linear, s-linear, left-handed circular, and right-handed circular. The two polarization gratings have been fabricated, and the working principle of the logic sequence generator has been proved by diffraction pattern analysis of polarization gratings.