Purpose–This study aims to explore the formation mechanism of aerodynamic noise of a high-speed maglev train and understand the characteristics of dipole and quadrupole sound sources of the maglev train at different ...Purpose–This study aims to explore the formation mechanism of aerodynamic noise of a high-speed maglev train and understand the characteristics of dipole and quadrupole sound sources of the maglev train at different speed levels.Design/methodology/approach–Based on large eddy simulation(LES)method and Kirchhoff–Ffowcs Williams and Hawkings(K-FWH)equations,the characteristics of dipole and quadrupole sound sources of maglev trains at different speed levels were simulated and analyzed by constructing reasonable penetrable integral surface.Findings–The spatial disturbance resulting from the separation of the boundary layer in the streamlined area of the tail car is the source of aerodynamic sound of the maglev train.The dipole sources of the train are mainly distributed around the radio terminals of the head and tail cars of the maglev train,the bottom of the arms of the streamlined parts of the head and tail cars and the nose tip area of the streamlined part of the tail car,and the quadrupole sources are mainly distributed in the wake area.When the train runs at three speed levels of 400,500 and 600 km$h1,respectively,the radiated energy of quadrupole source is 62.4%,63.3%and 71.7%,respectively,which exceeds that of dipole sources.Originality/value–This study can help understand the aerodynamic noise characteristics generated by the high-speed maglev train and provide a reference for the optimization design of its aerodynamic shape.展开更多
Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domain- containing 5 (FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates brow...Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domain- containing 5 (FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue (WAT) and uncoupling protein I (UCP1) expression, leading to an increase in total body energy expenditure by augmented UCPl-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones, including growth plate, trabecular bone, cortical bone, articular cartilage, and bone-tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal (IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-kB ligand (RANKL)- induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice.展开更多
Quantitative estimation of the influence of various factors,such as black carbon,snow grain,dust content,and water con tent on albedo is essential in obtaining an accurate albedo.In this paper,field measurement data,i...Quantitative estimation of the influence of various factors,such as black carbon,snow grain,dust content,and water con tent on albedo is essential in obtaining an accurate albedo.In this paper,field measurement data,including snow grain size,density,liquid water content,and snow depth was obtained.Black carbon and dust samples were collected from the snow surface.A simultaneous observation using ASD(Analytical Spectral Devices)spectral data was employed in the Qiyi glacier located on Qilian Mountain.The measurements were compared with results obtained from the Snow,Ice,and Aerosol Radiation(SNICAR)model.Additionally,a HYbrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)air mass backward trajectory model was used to track the source of black carbon.The simulation was found to correlate well with observed data.Liquid water content was the most influential factor of albedo among the several influencing fac tors,followed by black carbon content and snow grain size.Finally,snow density change had the least toward albedo.HYSPLIT atmospheric trajectories model can only approximately show the source of black carbon and not clearly indicate the source region of black carbon.展开更多
Damage caused by frost heave leads to costly maintenance in cold regions, like Hokkaido, Japan. Therefore, thestudy of the frost mechanism with experimental and numerical methods has been of great interest. Numerousmo...Damage caused by frost heave leads to costly maintenance in cold regions, like Hokkaido, Japan. Therefore, thestudy of the frost mechanism with experimental and numerical methods has been of great interest. Numerousmodels have been developed to describe the freezing process of saturated soil, which differs from the partiallysaturated conditions in the field. In fact, most subsurface soils are unsaturated. The freezing process of partiallysaturated soils is more complex than saturated soils, as the governing equations show strongly nonlinear characteristics. This study proposes a thermo-hydro-mechanical coupled model considering the heat transfer, waterinfiltration, and deformation of partially saturated soil to reproduce the freezing process of partially saturatedfrost susceptible soils distributed in Hokkaido. This model better considers the water-ice phase change and soilfreezing characteristic curve (SFCC) during freezing under field conditions. The results from the multiphysicssimulations agree well with the frost heave and water migration data from frost heave tests of Touryo soil andFujinomori soil. In addition, this study discussed the influence of the various factors on frost heave amount,including temperature gradients, overburden pressures, water supply conditions, cooling rates, and initial saturation. The simulation results indicate that the frost heave ratio is proportional to the initial degree of saturationand is inversely proportional to the cooling rate and overburden pressure.Moreover, simulation under the open system generates much more frost heave than under the closed system.Finally, the main features of the proposed model are revealed by simulating a closed-system frost heave test. Thesimulation results indicate that the proposed model adequately captures the coupling characteristics of water andice redistribution, temperature development, hydraulic conductivity, and suction in the freezing process. Togetherwith the decreased hydraulic conductivity, the increased suction controls the water flow in the freezing zone. Theinflow water driven by cryogenic suction gradient feeds the ice formation, leads to a rapid increase in total watercontent, expanding the voids that exceed the initial porosity and contributing to the frost heave.展开更多
Estimation of the influence of snow grain size and black carbon on albedo is essential in obtaining the accurate albedo. In this paper, field measurement data, including snow grain size, snow depth and density was obt...Estimation of the influence of snow grain size and black carbon on albedo is essential in obtaining the accurate albedo. In this paper, field measurement data, including snow grain size, snow depth and density was obtained. Black carbon samples were collected from the snow surface. A simultaneous observation using Analytical Spectral Devices was employed in the Qiyi Glacier located in the Qilian Mountain. Analytical Spectral Devices spectrum data were used to analyze spectral re- flectance of snow for different grain size and black carbon content. The measurements were compared with the results obtained from the Snow, Ice, and Aerosol Radiation model, and the simulation was found to correlate well with the ob- served data. However, the simulated albedo was near to 0.98 times of the measured albedo, so the other factors were as- sumed to be constant using the corrected Snow, Ice, and Aerosol Radiation model to estimate the influence of measured snow grain size and black carbon on albedo. Field measurements were controlled to fit the relationship between the snow grain size and black carbon in order to estimate the influence of these factors on the snow albedo.展开更多
In this paper, the significance and history of studying snow grain size is introduced. Based on the assumption that high reflectivity in the visible band and significant decreasing reflectivity of snow surface in the ...In this paper, the significance and history of studying snow grain size is introduced. Based on the assumption that high reflectivity in the visible band and significant decreasing reflectivity of snow surface in the infrared band, the grain size of snow, spherical and non-spherical, is sensitive to changes in remote sensing retrieval foundation. Also, models and algorithms applied in current studies are reviewed, together with their advantages and disadvantages. In addition, in order to obtain retrieval accuracy, some factors that may affect grain size are also discussed, such as temperature, wavelength, arid particle shape, as well as method authentication.展开更多
In recent years,computing art has developed rapidly with the in-depth cross study of artificial intelligence generated con-tent(AIGC)and the main features of artworks.Audio-visual content generation has gradually been...In recent years,computing art has developed rapidly with the in-depth cross study of artificial intelligence generated con-tent(AIGC)and the main features of artworks.Audio-visual content generation has gradually been applied to various practical tasks,including video or game score,assisting artists in creation,art education and other aspects,which demonstrates a broad application pro-spect.In this paper,we introduce innovative achievements in audio-visual content generation from the perspective of visual art genera-tion and auditory art generation based on artificial intelligence(Al).We outline the development tendency of image and music datasets,visual and auditory content modelling,and related automatic generation systems.The objective and subjective evaluation of generated samples plays an important role in the measurement of algorithm performance.We provide a cogeneration mechanism of audio-visual content in multimodal tasks from image to music and display the construction of specific stylized datasets.There are still many new op-portunities and challenges in the field of audio-visual synesthesia generation,and we provide a comprehensive discussion on them.展开更多
In this study, bimetallic nanoscale zero-valent iron particles(nZVI), including copper/nanoscale zero-valent iron particles(Cu/nZVI) and nickel/nanoscale zero-valent iron particles(Ni/nZVI), were synthesized by ...In this study, bimetallic nanoscale zero-valent iron particles(nZVI), including copper/nanoscale zero-valent iron particles(Cu/nZVI) and nickel/nanoscale zero-valent iron particles(Ni/nZVI), were synthesized by one-step liquid-phase reduction and applied for oxytetracycline(OTC) removal. The effects of contact time and initial p H on the removal efficiency were studied. The as-prepared nanoscale particles were characterized by scanning electron microscopy(SEM), energy dispersive spectroscopy(EDS) and X-ray diffraction(XRD). Finally, the degradation mechanisms of OTC utilizing the as-prepared nanoparticles were investigated by using X-ray photoelectron spectroscopy(XPS) and mass spectrometry(MS). Cu/n ZVI presented remarkable ability for OTC degradation and removed71.44% of OTC(100 mg/L) in 4 hr, while only 62.34% and 31.05% of OTC was degraded by Ni/nZVI and nZVI respectively. XPS and MS analysis suggested that OTC was broken down to form small molecules by ·OH radicals generated from the corrosion of Fe0. Cu/nZVI and Ni/n ZVI have been proved to have potential as materials for application in OTC removal because of their significant degradation ability toward OTC.展开更多
Cytokines exert powerful immunomodulatory effects that are critical to physiology and pathology in humans.The application of natural cytokines in clinical studies has not been clearly established,and there are often p...Cytokines exert powerful immunomodulatory effects that are critical to physiology and pathology in humans.The application of natural cytokines in clinical studies has not been clearly established,and there are often problems associated with toxicity or lack of efficacy.The key reasons can be attributed to the pleiotropy of cytokine receptors and undesired activation of off-target cells.With a deeper understanding of the structural principles and functional signals of cytokine-receptor interactions,artificial modification of cytokine signaling through protein engineering and synthetic immunology has become an increasingly feasible and powerful approach.Engineered cytokines are designed to selectively target cells.Herein,the theoretical and experimental evidence of cytokine engineering is reviewed,and the“supercytokines”resulting from structural enhancement and the“immunocytokines”generated by antibody fusion are described.Finally,the“engager cytokines”formed by the crosslinking of cytokines and bispecific immune engagers and other synthetic cytokines formed by nonnatural analogs are also discussed.展开更多
Semiconductor photocatalysis is one of the most widely used environment-friendly technologies for removing various contaminants.As a well-developed photocatalyst,titanium dioxide(TiO_(2))still has limits in its wide b...Semiconductor photocatalysis is one of the most widely used environment-friendly technologies for removing various contaminants.As a well-developed photocatalyst,titanium dioxide(TiO_(2))still has limits in its wide bandgap and rapid recombination rate of photogenerated charge carriers.Recently,black TiO_(2)appears as a strong candidate in the improvement of sunlight harvesting,because of its excellent absorption capacity and utilization of solar radiation.Despite extensive applications in both environmental and energy fields,the use of black TiO_(2)as a photocatalyst in pollutant removal is ambiguous.The primary objective of the review is to comprehensively evaluate the applications of black TiO_(2)in photocatalytic removal of contaminants,including conventional organic contaminants,emerging contaminants,microbes,and heavy metals.The basic properties,photocatalytic mechanism,and synthesis of black TiO_(2)have been summarized and analyzed.Moreover,the stability and recoverability of black TiO_(2)have also been discussed.Finally,the perspectives of the application of black TiO_(2)in pollutant removal have been further discussed.展开更多
Three binuclear rare earth based complexes combining RE ions with semirigid tricarboxylic ligand(H_(3)L).namely,[RE_(2)(L)_(2)(DMF)_(4)][RE=Gd,Tb,and Dy;H_(3)L=5-((4-Carboxybenzyl)oxy)isophthalic acid;DMF=N,N-dimethyl...Three binuclear rare earth based complexes combining RE ions with semirigid tricarboxylic ligand(H_(3)L).namely,[RE_(2)(L)_(2)(DMF)_(4)][RE=Gd,Tb,and Dy;H_(3)L=5-((4-Carboxybenzyl)oxy)isophthalic acid;DMF=N,N-dimethylformamide]complexes,were fabricated success fully.The RE_(2)(L)_(2)(DMF)_(4) co mplexe s consist of two central RE ions with the same coordination environment which were connected by two tridentate bridging carboxylic groups and two syn-syn bidentate bridging carboxylic groups originating from the L^(3-)ligands to form the{RE_(2)}dimeric unit,and thus provides the basis for further constructing a dense three-dimensional(3 D)network structure.Moreover,the present RE_(2)(L)_(2)(DMF)_(4) complexes can be described by a topology diagram with the topology point symbol of{4^(2)·6}_(2){4^(4)·6^(2)·8^(7)·10^(2)}.Weak antiferromagnetic(AFM)coupling between the adjacent RE ions for all the present complexes was found according to the magnetic calculations.The observed significant cryogenic magnetocaloric effect(MCE)with the maximum magnetic entropy change-ΔS_(M)^(max) to be 26.3 J/(kg·K)withΔH=7 T in Gd_(2)(L)_(2)(DMF)_(4) complex makes it competitive for the cryogenic magnetic refrigerant.Moreover,the slow magnetic relaxation behavior at 0.2 T dc field with an obvious large U_(eff)/k=45(4)K and τ_(0)=6.5(2)×10^(-10)s was confirmed in Dy_(2)(L)_(2)(DMF)_(4)complex.This work not only provides an effective strategy for obtaining molecular materials with high MCE,but also confirms that tricarboxylate ligands are the ideal choice for constructing stable high dimensional geometric structures.展开更多
The living cells have been emerged as useful platforms for drug delivery due to their advantages of good liquidity,stability,and low immunogenicity.In this review,we summarized the development of living cells-based dr...The living cells have been emerged as useful platforms for drug delivery due to their advantages of good liquidity,stability,and low immunogenicity.In this review,we summarized the development of living cells-based drug delivery systems.The drug loading methods,applications,and advantages of living cell drug delivery systems were summarized.Different living cells for drug delivery,the mechanisms of action,therapeutic applications,as well as main features were summarized and highlighted.The recent research progress and challenges were discussed.The future directions and prospects were proposed.展开更多
The drug resistance of chemotherapy is a major challenge to overcome for antineoplastic agents and the reverse of drug resistant is essential for cancer therapy. Herein, we developed a drug delivery system which can s...The drug resistance of chemotherapy is a major challenge to overcome for antineoplastic agents and the reverse of drug resistant is essential for cancer therapy. Herein, we developed a drug delivery system which can simultaneously detect/reverse the drug resistance and perform synergetic treatment of cancer. In this work, we integrated cyanine5(Cy5) modified mi RNA(let-7 i)(Cy5-mi RNA) and platinum onto nano-graphene oxide(NGO)(30-50 nm) platform to achieve simultaneously detection/reversion of drug resistance and synergetic treatment of cisplatin resistant SKOV3 cells(SKOV3 DDP cells). The Cy5-mi RNA adsorbed on NGO could selectively bind the drug resistance related m RNA follow by suppress the expression of drug resistance m RNA, and the binding simultaneously induced the release of Cy5-mi RNA from the NGO, thus the fluorescence signal of Cy5 recovered and could be used for drug resistance monitoring.Moreover, the mi RNA suppressed the Cyclin D1 protein expressions thus reversed the drug resistance. The loaded platinum(Ⅳ)(Pt(Ⅳ)) was converted to the therapeutic platinum(Ⅱ)(Pt(Ⅱ)) in both tumor acidic and reductive environment responsive behavior. NGO furtherly performed photothermal therapy under near infrared(NIR) laser irradiation and enhanced the therapeutic effect. All in all, this nanoplatform realized detection/reversion of the drug resistance as well as synergetic chemical-photothermal treatment of ovarian cancer cells, which holds great promise in the treatment of drug resistant cancer cells.展开更多
In this work,we printed a Nafion precursor membrane by fused deposition modeling(FDM)rapid prototyping technology and further fabricated IPMCs by electroless plating.The ion-exchange capacity of the Nafion membrane wa...In this work,we printed a Nafion precursor membrane by fused deposition modeling(FDM)rapid prototyping technology and further fabricated IPMCs by electroless plating.The ion-exchange capacity of the Nafion membrane was tested,and the morphology of IPMCs was observed.The electro-mechanical properties of IPMCs under AC voltage inputs were studied,and grasping experiments were performed.The results show that the Nafion membrane after hydrolysis has a good ion-exchange ability and water-holding capacity.SEM observed that the thickness of the IPMC’s electrode layer was about 400 nm,and the platinum layer was tightly combined with the substrate membrane.When using a square wave input of 3.5 V and 0.1 Hz,the maximum current of IPMCs reached 0.30 A,and the displacement and blocking force were 7.57 mm and 10.5 mN,respectively.The new fabrication process ensures the good driving performance of the printed IPMC.And two pieces of IPMCs can capture the irregular objects successfully,indicating the feasibility of printing IPMCs by FDM technology.This paper provides a new and simple method for the fabrication of three-dimensional IPMCs,which can be further applied in flexible grippers and soft robotics.展开更多
基金The research was supported by the National Key Research and Development Program(Grant No.2020YFA0710903)the Financial Funding Project for Central Colleges and Universities(Grant No.202045014)the Science and Technology Research and Development Program of China State Railway Group Co.,Ltd.(Grant No.P2019J008).
文摘Purpose–This study aims to explore the formation mechanism of aerodynamic noise of a high-speed maglev train and understand the characteristics of dipole and quadrupole sound sources of the maglev train at different speed levels.Design/methodology/approach–Based on large eddy simulation(LES)method and Kirchhoff–Ffowcs Williams and Hawkings(K-FWH)equations,the characteristics of dipole and quadrupole sound sources of maglev trains at different speed levels were simulated and analyzed by constructing reasonable penetrable integral surface.Findings–The spatial disturbance resulting from the separation of the boundary layer in the streamlined area of the tail car is the source of aerodynamic sound of the maglev train.The dipole sources of the train are mainly distributed around the radio terminals of the head and tail cars of the maglev train,the bottom of the arms of the streamlined parts of the head and tail cars and the nose tip area of the streamlined part of the tail car,and the quadrupole sources are mainly distributed in the wake area.When the train runs at three speed levels of 400,500 and 600 km$h1,respectively,the radiated energy of quadrupole source is 62.4%,63.3%and 71.7%,respectively,which exceeds that of dipole sources.Originality/value–This study can help understand the aerodynamic noise characteristics generated by the high-speed maglev train and provide a reference for the optimization design of its aerodynamic shape.
基金supported by a R01DE21464 through the National Institutes of Healthan Innovation in Oral Care Award through International Association for Dental Research and Glaxo Smith Kline Consumer Healthcare+2 种基金an Award through International Team of Implantology to JCby GZUCM Science Fund for Creative Research Groups(2016KYTD10)GZUCM Torch Program(A1-AFD015142Z08)to JZ
文摘Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domain- containing 5 (FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue (WAT) and uncoupling protein I (UCP1) expression, leading to an increase in total body energy expenditure by augmented UCPl-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones, including growth plate, trabecular bone, cortical bone, articular cartilage, and bone-tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal (IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-kB ligand (RANKL)- induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice.
基金provided by the National Natural Science Foundation of China(Grant Nos.41501069,41571415)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.XDA20060201,XDA19070302)Science&Technology Basic Resource Investigation Program of China(Grant No.2017YFC0404302).
文摘Quantitative estimation of the influence of various factors,such as black carbon,snow grain,dust content,and water con tent on albedo is essential in obtaining an accurate albedo.In this paper,field measurement data,including snow grain size,density,liquid water content,and snow depth was obtained.Black carbon and dust samples were collected from the snow surface.A simultaneous observation using ASD(Analytical Spectral Devices)spectral data was employed in the Qiyi glacier located on Qilian Mountain.The measurements were compared with results obtained from the Snow,Ice,and Aerosol Radiation(SNICAR)model.Additionally,a HYbrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)air mass backward trajectory model was used to track the source of black carbon.The simulation was found to correlate well with observed data.Liquid water content was the most influential factor of albedo among the several influencing fac tors,followed by black carbon content and snow grain size.Finally,snow density change had the least toward albedo.HYSPLIT atmospheric trajectories model can only approximately show the source of black carbon and not clearly indicate the source region of black carbon.
基金This research was supported in part by Grant-in-Aids for Scientific Research(A,16H02360)and(B,17H03307)from the Japan Society for the Promotion of Science(JSPS)KAKENHI.
文摘Damage caused by frost heave leads to costly maintenance in cold regions, like Hokkaido, Japan. Therefore, thestudy of the frost mechanism with experimental and numerical methods has been of great interest. Numerousmodels have been developed to describe the freezing process of saturated soil, which differs from the partiallysaturated conditions in the field. In fact, most subsurface soils are unsaturated. The freezing process of partiallysaturated soils is more complex than saturated soils, as the governing equations show strongly nonlinear characteristics. This study proposes a thermo-hydro-mechanical coupled model considering the heat transfer, waterinfiltration, and deformation of partially saturated soil to reproduce the freezing process of partially saturatedfrost susceptible soils distributed in Hokkaido. This model better considers the water-ice phase change and soilfreezing characteristic curve (SFCC) during freezing under field conditions. The results from the multiphysicssimulations agree well with the frost heave and water migration data from frost heave tests of Touryo soil andFujinomori soil. In addition, this study discussed the influence of the various factors on frost heave amount,including temperature gradients, overburden pressures, water supply conditions, cooling rates, and initial saturation. The simulation results indicate that the frost heave ratio is proportional to the initial degree of saturationand is inversely proportional to the cooling rate and overburden pressure.Moreover, simulation under the open system generates much more frost heave than under the closed system.Finally, the main features of the proposed model are revealed by simulating a closed-system frost heave test. Thesimulation results indicate that the proposed model adequately captures the coupling characteristics of water andice redistribution, temperature development, hydraulic conductivity, and suction in the freezing process. Togetherwith the decreased hydraulic conductivity, the increased suction controls the water flow in the freezing zone. Theinflow water driven by cryogenic suction gradient feeds the ice formation, leads to a rapid increase in total watercontent, expanding the voids that exceed the initial porosity and contributing to the frost heave.
基金supported by "Strategic Priority Research Program (B)" of the Chinese Academy of Sciences (Grant No. XDB03030204)SKLCS (No. SKLCS-OP-2014-03)Major Research of National Natural Science Foundation of China (Grant No. 41190084)
文摘Estimation of the influence of snow grain size and black carbon on albedo is essential in obtaining the accurate albedo. In this paper, field measurement data, including snow grain size, snow depth and density was obtained. Black carbon samples were collected from the snow surface. A simultaneous observation using Analytical Spectral Devices was employed in the Qiyi Glacier located in the Qilian Mountain. Analytical Spectral Devices spectrum data were used to analyze spectral re- flectance of snow for different grain size and black carbon content. The measurements were compared with the results obtained from the Snow, Ice, and Aerosol Radiation model, and the simulation was found to correlate well with the ob- served data. However, the simulated albedo was near to 0.98 times of the measured albedo, so the other factors were as- sumed to be constant using the corrected Snow, Ice, and Aerosol Radiation model to estimate the influence of measured snow grain size and black carbon on albedo. Field measurements were controlled to fit the relationship between the snow grain size and black carbon in order to estimate the influence of these factors on the snow albedo.
基金provided by National Science Fundamental Key Project(40930526,40901041)Science Research Program of Global Change Research of China(Grant No.2010CB951404)
文摘In this paper, the significance and history of studying snow grain size is introduced. Based on the assumption that high reflectivity in the visible band and significant decreasing reflectivity of snow surface in the infrared band, the grain size of snow, spherical and non-spherical, is sensitive to changes in remote sensing retrieval foundation. Also, models and algorithms applied in current studies are reviewed, together with their advantages and disadvantages. In addition, in order to obtain retrieval accuracy, some factors that may affect grain size are also discussed, such as temperature, wavelength, arid particle shape, as well as method authentication.
基金This work was supported by National Natural Science Foundation of China(No.62176006)the National Key Research and Development Program of China(No.2022YFF0902302).
文摘In recent years,computing art has developed rapidly with the in-depth cross study of artificial intelligence generated con-tent(AIGC)and the main features of artworks.Audio-visual content generation has gradually been applied to various practical tasks,including video or game score,assisting artists in creation,art education and other aspects,which demonstrates a broad application pro-spect.In this paper,we introduce innovative achievements in audio-visual content generation from the perspective of visual art genera-tion and auditory art generation based on artificial intelligence(Al).We outline the development tendency of image and music datasets,visual and auditory content modelling,and related automatic generation systems.The objective and subjective evaluation of generated samples plays an important role in the measurement of algorithm performance.We provide a cogeneration mechanism of audio-visual content in multimodal tasks from image to music and display the construction of specific stylized datasets.There are still many new op-portunities and challenges in the field of audio-visual synesthesia generation,and we provide a comprehensive discussion on them.
基金Natural Science Foundation of Hainan Province(Grant No.320QN302)the Central Public-interest Scientific Institution Basal Research Fund for the Chinese Academy of Tropical Agricultural Sciences(Grant No.1251632022005)+1 种基金the Key Laboratory of Tropical Fruits and Vegetables Quality and Safety for State Market Regulation(Grant No.ZX-2022002)Open Fund of Hainan Provincial Key Laboratory of Quality and Safety for Tropical Fruits and Vegetables(Grant No.KFKT2021002)。
基金supported by grants from Tai Shan Scholar Foundation(No.ts 201511003)
文摘In this study, bimetallic nanoscale zero-valent iron particles(nZVI), including copper/nanoscale zero-valent iron particles(Cu/nZVI) and nickel/nanoscale zero-valent iron particles(Ni/nZVI), were synthesized by one-step liquid-phase reduction and applied for oxytetracycline(OTC) removal. The effects of contact time and initial p H on the removal efficiency were studied. The as-prepared nanoscale particles were characterized by scanning electron microscopy(SEM), energy dispersive spectroscopy(EDS) and X-ray diffraction(XRD). Finally, the degradation mechanisms of OTC utilizing the as-prepared nanoparticles were investigated by using X-ray photoelectron spectroscopy(XPS) and mass spectrometry(MS). Cu/n ZVI presented remarkable ability for OTC degradation and removed71.44% of OTC(100 mg/L) in 4 hr, while only 62.34% and 31.05% of OTC was degraded by Ni/nZVI and nZVI respectively. XPS and MS analysis suggested that OTC was broken down to form small molecules by ·OH radicals generated from the corrosion of Fe0. Cu/nZVI and Ni/n ZVI have been proved to have potential as materials for application in OTC removal because of their significant degradation ability toward OTC.
基金supported by the Shenzhen Institute of Synthetic Biology Scientific Research Program(ZTXM20214003)Natural Science Foundation of China(82122055,81872318)Natural Science Foundation of Anhui Province(2108085J13).
文摘Cytokines exert powerful immunomodulatory effects that are critical to physiology and pathology in humans.The application of natural cytokines in clinical studies has not been clearly established,and there are often problems associated with toxicity or lack of efficacy.The key reasons can be attributed to the pleiotropy of cytokine receptors and undesired activation of off-target cells.With a deeper understanding of the structural principles and functional signals of cytokine-receptor interactions,artificial modification of cytokine signaling through protein engineering and synthetic immunology has become an increasingly feasible and powerful approach.Engineered cytokines are designed to selectively target cells.Herein,the theoretical and experimental evidence of cytokine engineering is reviewed,and the“supercytokines”resulting from structural enhancement and the“immunocytokines”generated by antibody fusion are described.Finally,the“engager cytokines”formed by the crosslinking of cytokines and bispecific immune engagers and other synthetic cytokines formed by nonnatural analogs are also discussed.
基金supported by the National Key Research and Development Plan(Nos.2016YFC0502800)Natural Science Foundation(No.U2040212,51779008)+1 种基金MWR/CAS Institute of Hydroecology(No.1440020035)the Natural Science and Engineering Research Council of Canada。
文摘Semiconductor photocatalysis is one of the most widely used environment-friendly technologies for removing various contaminants.As a well-developed photocatalyst,titanium dioxide(TiO_(2))still has limits in its wide bandgap and rapid recombination rate of photogenerated charge carriers.Recently,black TiO_(2)appears as a strong candidate in the improvement of sunlight harvesting,because of its excellent absorption capacity and utilization of solar radiation.Despite extensive applications in both environmental and energy fields,the use of black TiO_(2)as a photocatalyst in pollutant removal is ambiguous.The primary objective of the review is to comprehensively evaluate the applications of black TiO_(2)in photocatalytic removal of contaminants,including conventional organic contaminants,emerging contaminants,microbes,and heavy metals.The basic properties,photocatalytic mechanism,and synthesis of black TiO_(2)have been summarized and analyzed.Moreover,the stability and recoverability of black TiO_(2)have also been discussed.Finally,the perspectives of the application of black TiO_(2)in pollutant removal have been further discussed.
基金Project supported by the National Natural Science Foundation of China(91963123)the State Key Laboratory of Solidification Processing in NWPU(SKLSP202020)+1 种基金the Ten Thousand Talents Plan of Zhejiang Province of China(2018R52003)the Fundamental Research Funds for the Provincial University of Zhejiang(GK199900299012-022)。
文摘Three binuclear rare earth based complexes combining RE ions with semirigid tricarboxylic ligand(H_(3)L).namely,[RE_(2)(L)_(2)(DMF)_(4)][RE=Gd,Tb,and Dy;H_(3)L=5-((4-Carboxybenzyl)oxy)isophthalic acid;DMF=N,N-dimethylformamide]complexes,were fabricated success fully.The RE_(2)(L)_(2)(DMF)_(4) co mplexe s consist of two central RE ions with the same coordination environment which were connected by two tridentate bridging carboxylic groups and two syn-syn bidentate bridging carboxylic groups originating from the L^(3-)ligands to form the{RE_(2)}dimeric unit,and thus provides the basis for further constructing a dense three-dimensional(3 D)network structure.Moreover,the present RE_(2)(L)_(2)(DMF)_(4) complexes can be described by a topology diagram with the topology point symbol of{4^(2)·6}_(2){4^(4)·6^(2)·8^(7)·10^(2)}.Weak antiferromagnetic(AFM)coupling between the adjacent RE ions for all the present complexes was found according to the magnetic calculations.The observed significant cryogenic magnetocaloric effect(MCE)with the maximum magnetic entropy change-ΔS_(M)^(max) to be 26.3 J/(kg·K)withΔH=7 T in Gd_(2)(L)_(2)(DMF)_(4) complex makes it competitive for the cryogenic magnetic refrigerant.Moreover,the slow magnetic relaxation behavior at 0.2 T dc field with an obvious large U_(eff)/k=45(4)K and τ_(0)=6.5(2)×10^(-10)s was confirmed in Dy_(2)(L)_(2)(DMF)_(4)complex.This work not only provides an effective strategy for obtaining molecular materials with high MCE,but also confirms that tricarboxylate ligands are the ideal choice for constructing stable high dimensional geometric structures.
基金supported by the Huxiang Young Talent Program of Hunan Province(2018RS3005)the Innovation-Driven Project of Cen-tral South University(2020CX048)+3 种基金the National Natural Science Foun-dation of China(81301258),the Natural Science Foundation of Hu-nan Province(2019JJ60071,2020JJ4680)the Natural Science Founda-tion of Changsha(kq2202131)the Shenghua Yuying Project of Central South University,the Postgraduate Innovation Project of Central South University(2020zzts819,2020zzts408,2020zzts409,2021zzts0977,2021zzts0979)the Open-End Fund for the Valuable and Precision Instruments of Central South University.
文摘The living cells have been emerged as useful platforms for drug delivery due to their advantages of good liquidity,stability,and low immunogenicity.In this review,we summarized the development of living cells-based drug delivery systems.The drug loading methods,applications,and advantages of living cell drug delivery systems were summarized.Different living cells for drug delivery,the mechanisms of action,therapeutic applications,as well as main features were summarized and highlighted.The recent research progress and challenges were discussed.The future directions and prospects were proposed.
基金supported by the Huxiang Young Talent Program of Hunan Province (No.2018RS3005)the InnovationDriven Project of Central South University (No.2020CX048)+6 种基金the Changsha Science and Technology Plan Project (Nos.kq2005001,kq2004086)the National Natural Science Foundation of China (No.81301258)the Natural Science Foundation of Hunan Province (Nos.2019JJ60071,2020JJ4680)the Shenghua Yuying Project of Central South University,the Hunan Provincial Graduate Research and Innovation Project (No.CX20190242)National College Students’ Innovation and Entrepreneurship Training Program (Nos.S2020105330414,S202010533015X,8304180412)the Postgraduate Innovation Project of Central South University (Nos.2020zzts819,2020zzts408,2020zzts409,2021zzts0977,2021zzts0979)the Open-End Fund for the Valuable and Precision Instruments of Central South University。
文摘The drug resistance of chemotherapy is a major challenge to overcome for antineoplastic agents and the reverse of drug resistant is essential for cancer therapy. Herein, we developed a drug delivery system which can simultaneously detect/reverse the drug resistance and perform synergetic treatment of cancer. In this work, we integrated cyanine5(Cy5) modified mi RNA(let-7 i)(Cy5-mi RNA) and platinum onto nano-graphene oxide(NGO)(30-50 nm) platform to achieve simultaneously detection/reversion of drug resistance and synergetic treatment of cisplatin resistant SKOV3 cells(SKOV3 DDP cells). The Cy5-mi RNA adsorbed on NGO could selectively bind the drug resistance related m RNA follow by suppress the expression of drug resistance m RNA, and the binding simultaneously induced the release of Cy5-mi RNA from the NGO, thus the fluorescence signal of Cy5 recovered and could be used for drug resistance monitoring.Moreover, the mi RNA suppressed the Cyclin D1 protein expressions thus reversed the drug resistance. The loaded platinum(Ⅳ)(Pt(Ⅳ)) was converted to the therapeutic platinum(Ⅱ)(Pt(Ⅱ)) in both tumor acidic and reductive environment responsive behavior. NGO furtherly performed photothermal therapy under near infrared(NIR) laser irradiation and enhanced the therapeutic effect. All in all, this nanoplatform realized detection/reversion of the drug resistance as well as synergetic chemical-photothermal treatment of ovarian cancer cells, which holds great promise in the treatment of drug resistant cancer cells.
基金This research was supported by the Joint Funds of the National Natural Science Foundation of China(U1637101)and NSFC(51605220)the Natural Science Foundation of Jiangsu Province(BK20160793)Open Funding from the Shanghai Key Laboratory of Spacecraft Mechanism,Open Project funding form Hubei Key Laboratory of Hydroelectric Machinery Design&Maintenance(2017KJX11).
文摘In this work,we printed a Nafion precursor membrane by fused deposition modeling(FDM)rapid prototyping technology and further fabricated IPMCs by electroless plating.The ion-exchange capacity of the Nafion membrane was tested,and the morphology of IPMCs was observed.The electro-mechanical properties of IPMCs under AC voltage inputs were studied,and grasping experiments were performed.The results show that the Nafion membrane after hydrolysis has a good ion-exchange ability and water-holding capacity.SEM observed that the thickness of the IPMC’s electrode layer was about 400 nm,and the platinum layer was tightly combined with the substrate membrane.When using a square wave input of 3.5 V and 0.1 Hz,the maximum current of IPMCs reached 0.30 A,and the displacement and blocking force were 7.57 mm and 10.5 mN,respectively.The new fabrication process ensures the good driving performance of the printed IPMC.And two pieces of IPMCs can capture the irregular objects successfully,indicating the feasibility of printing IPMCs by FDM technology.This paper provides a new and simple method for the fabrication of three-dimensional IPMCs,which can be further applied in flexible grippers and soft robotics.