Intelligent Recognition Using Ultralight Multifunctional Nano‑Layered Carbon Aerogel Sensors with Human‑Like Tactile Perception

Humans can perceive our complex world through multi-sensory fusion.Under limited visual conditions,people can sense a variety of tactile signals to identify objects accurately and rapidly.However,replicating this unique capability in robots remains a significant challenge.Here,we present a new form of ultralight multifunctional tactile nano-layered carbon aerogel sensor that provides pressure,temperature,material recognition and 3D location capabilities,which is combined with multimodal supervised learning algorithms for object recognition.The sensor exhibits human-like pressure(0.04–100 kPa)and temperature(21.5–66.2℃)detection,millisecond response times(11 ms),a pressure sensitivity of 92.22 kPa^(−1)and triboelectric durability of over 6000 cycles.The devised algorithm has universality and can accommodate a range of application scenarios.The tactile system can identify common foods in a kitchen scene with 94.63%accuracy and explore the topographic and geomorphic features of a Mars scene with 100%accuracy.This sensing approach empowers robots with versatile tactile perception to advance future society toward heightened sensing,recognition and intelligence.

BMI-1 activates hepatic stellate cells to promote the epithelialmesenchymal transition of colorectal cancer cells

BACKGROUND Activated hepatic stellate cells(aHSCs)are the major source of cancer-associated fibroblasts in the liver.Although the crosstalk between aHSCs and colorectal cancer(CRC)cells supports liver metastasis(LM),the mechanisms are largely unknown.AIM To explore the role of BMI-1,a polycomb group protein family member,which is highly expressed in LM,and the interaction between aHSCs and CRC cells in promoting CRC liver metastasis(CRLM).METHODS Immunohistochemistry was carried out to examine BMI-1 expression in LM and matched liver specimens of CRC.The expression levels of BMI-1 in mouse liver during CRLM(0,7,14,21,and 28 d)were detected by Western blotting(WB)and the quantitative polymerase chain reaction(qPCR)assay.We overexpressed BMI-1 in HSCs(LX2)by lentivirus infection and tested the molecular markers of aHSCs by WB,qPCR,and the immunofluorescence assay.CRC cells(HCT116 and DLD1)were cultured in HSC-conditioned medium(LX2 NC CM or LX2 BMI-1 CM).CM-induced CRC cell proliferation,migration,epithelial-mesenchymal transition(EMT)phenotype,and transforming growth factor beta(TGF-β)/SMAD pathway changes were investigated in vitro.A mouse subcutaneous xenotransplantation tumor model was established by co-implantation of HSCs(LX2 NC or LX2 BMI-1)and CRC cells to investigate the effects of HSCs on tumor growth and the EMT phenotype in vivo.RESULTS Positive of BMI-1 expression in the liver of CRLM patients was 77.8%.The expression level of BMI-1 continued to increase during CRLM in mouse liver cells.LX2 overexpressed BMI-1 was activated,accompanied by increased expression level of alpha smooth muscle actin,fibronectin,TGF-β1,matrix metalloproteinases,and interleukin 6.CRC cells cultured in BMI-1 CM exhibited enhanced proliferation and migration ability,EMT phenotype and activation of the TGF-β/SMAD pathway.In addition,the TGF-βR inhibitor SB-505124 diminished the effect of BMI-1 CM on SMAD2/3 phosphorylation in CRC cells.Furthermore,BMI-1 overexpressed LX2 HSCs promoted tumor growth and the EMT phenotype in vivo.CONCLUSION High expression of BMI-1 in liver cells is associated with CRLM progression.BMI-1 activates HSCs to secrete factors to form a prometastatic environment in the liver,and aHSCs promote proliferation,migration,and the EMT in CRC cells partially through the TGF-β/SMAD pathway.

Adversarial Learning for Distant Supervised Relation Extraction

Recently,many researchers have concentrated on using neural networks to learn features for Distant Supervised Relation Extraction(DSRE).These approaches generally use a softmax classifier with cross-entropy loss,which inevitably brings the noise of artificial class NA into classification process.To address the shortcoming,the classifier with ranking loss is employed to DSRE.Uniformly randomly selecting a relation or heuristically selecting the highest score among all incorrect relations are two common methods for generating a negative class in the ranking loss function.However,the majority of the generated negative class can be easily discriminated from positive class and will contribute little towards the training.Inspired by Generative Adversarial Networks(GANs),we use a neural network as the negative class generator to assist the training of our desired model,which acts as the discriminator in GANs.Through the alternating optimization of generator and discriminator,the generator is learning to produce more and more discriminable negative classes and the discriminator has to become better as well.This framework is independent of the concrete form of generator and discriminator.In this paper,we use a two layers fully-connected neural network as the generator and the Piecewise Convolutional Neural Networks(PCNNs)as the discriminator.Experiment results show that our proposed GAN-based method is effective and performs better than state-of-the-art methods.

基于网络药理学探究温阳强心颗粒抗心肌缺血再灌注损伤的作用机制

目的通过网络药理学方法探讨温阳强心颗粒复方治疗心肌缺血再灌注损伤的作用机制。方法利用中药系统药理学分析平台(TCMSP)找出温阳强心颗粒复方12味中药所有化学成分和作用靶点,从GenCards数据库中筛选出心肌缺血再灌注损伤的相关靶点,找出药物靶点和疾病靶点的交集,利用STRING平台构建蛋白-蛋白相互作用(PPI)网络模型。应用Matescape进行KEGG通路富集分析和GO富集分析,揭示温阳强心颗粒抗心肌缺血再灌注损伤的作用机制。结果筛选得到了65个治疗心肌缺血再灌注损伤的靶点。温阳强心颗粒治疗心肌缺血再灌注损伤可能涉及(PI3K)-Akt、IL-17、TNF、HIF-1、AGE-RAGE等信号通路。结论温阳强心颗粒治疗心肌缺血再灌注损伤的作用机制是通过多通路、多靶点、多组分来实现的,用温阳强心颗粒治疗心肌缺血再灌注损伤具有一定的临床价值。

Design of Power Supply for On-line Monitoring System of Transmission Lines

This paper uses CT to gain the energy directly from the high-voltage transmission line, to address the problem of power supply for monitoring system in high voltage side of transmission line. The draw-out power coil can induce voltage from the transmission line, using single-chip microcomputer to analog and output PMW wave to control the charging module, provides a stable 3.4 V DC voltage to the load, and solve the problem of easy saturating of core. The power supply based on this kind of draw-out power coil has undergone the overall testing, and it is verified-showing that it can properly work in a non-saturated status within the current range of 50 - 1000 A, and provide a stable output. The equipment also design protection circuit to improve the reliability to avid the impacts of the impulse current or short-circuit current. It effectively solves the problem of power supply for On-line Monitoring System of Transmission.

Characteristic Analysis of DS18B20 Temperature Sensor in the High-voltage Transmission Lines’ Dynamic Capacity Increase

Dynamic capacity increase in high voltage electric power transmission line is currently the most economical method for solving electric power transmission bottleneck nowadays. DS18B20 temperature sensor is applied to the dynamic capacity increase of high voltage transmission lines to measure the conductor temperature and ambient temperature. The paper is focused on the experiment of DS18B20 both in the laboratory and outside. From the result of the lab temperature measurement data analysis, using 4 DS18B20’s is the most suitable plan, considering both accuracy and economical efficiency. In the experiment outside, we get four groups of conductor (uncharged) temperature and four groups of ambient temperature. The data proved that DS18B20 has good stability, and small measurement error. It is suitable for measuring the temperature of conductor and ambient in dynamic capacity increase, and helpful to improve the accuracy of the calculation of capacity increasing.

Experiment of New Additives Effect on Gas Hydrate Formation

Natural gas hydrate has tremendous gas storage capacity;natural gas hydrate can be used to store and transport energy. The current problem faced is how to improve the hydrate formation rate and storage capacity, and form continuously. Compared to the pure water and SDBS solution, the ionic solution [HMIPS]OTs made by the team was the excellent additive and ensured the best reaction concentration range. Specific effects of different additives on hydrate formation were summarized;hydrate formation mechanism of additives was expounded. Considering the investment cost, operation cost, simple and stable operation of different surfactants, it is thought that the study of different additives mechanisms and developing the new efficient additive have the important value.

Japanese Aquatic Resources Management and Its Enlightenment to China

This article briefly reviewed the history of fishery resource management,especially the basic laws,concepts and basic techniques of aquatic resource management in Japan. It was concluded that the experience of management systems,basic methods,etc. in Japan,as a county that has earlier protected and managed aquatic resources,is worth learning by the establishment of China's aquatic resource management system.

SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice

Fluid intelligence is a cognitive domain that encompasses general reasoning, pattern recognition, and problem-solving abilities independent of task-specific experience. Understanding its genetic and neural underpinnings is critical yet challenging for predicting human development, lifelong health, and well-being. One approach to address this challenge is to map the network of correlations between intelligence and other constructs. In the current study, we performed a genome-wide association study using fluid intelligence quotient scores from the UK Biobank to explore the genetic architecture of the associations between obesity risk and fluid intelligence. Our results revealed novel common genetic loci (SH2B1, TUFM, ATP2A1, and FOXO3) underlying the association between fluid intelligence and body metabolism. Surprisingly, we demonstrated that SH2B1 variation influenced fluid intelligence independently of its effects on metabolism but partially mediated its association with bilateral hippocampal volume. Consistently, selective genetic ablation of Sh2b1 in the mouse hippocampus, particularly in inhibitory neurons, but not in excitatory neurons, significantly impaired working memory, short-term novel object recognition memory, and behavioral flexibility, but not spatial learning and memory, mirroring the human intellectual performance. Single-cell genetic profiling of Sh2B1-regulated molecular pathways revealed that Sh2b1 deletion resulted in aberrantly enhanced extracellular signal-regulated kinase (ERK) signaling, whereas pharmacological inhibition of ERK signaling reversed the associated behavioral impairment. Our cross-species study thus provides unprecedented insight into the role of SH2B1 in fluid intelligence and has implications for understanding the genetic and neural underpinnings of lifelong mental health and well-being.

Iontronic pressure sensor with high sensitivity and linear response over a wide pressure range based on soft micropillared electrodes

Electronic skins and flexible pressure sensors are important devices for advanced healthcare and intelligent robotics.Sensitivity is a key parameter of flexible pressure sensors.Whereas introducing surface microstructures in a capacitive-type sensor can significantly improve its sensitivity,the signal becomes nonlinear and the pressure response range gets much narrower,significantly limiting the applications of flexible pressure sensors.Here,we designed a pressure sensor that utilizes a nanoscale iontronic interface of an ionic gel layer and a micropillared electrode,for highly linear capacitance-to-pressure response and high sensitivity over a wide pressure range.The micropillars undergo three stages of deformation upon loading:initial contact(0-6 k Pa)and structure buckling(6-12 k Pa)that exhibit a low and nonlinear response,as well as a post-buckling stage that has a high signal linearity with high sensitivity(33.16 k Pa-1)over a broad pressure range of 12-176 k Pa.The high linearity lies in the subtle balance between the structure compression and mechanical matching of the two materials at the gel-electrode interface.Our sensor has been applied in pulse detection,plantar pressure mapping,and grasp task of an artificial limb.This work provides a physical insight in achieving linear response through the design of appropriate microstructures and selection of materials with suitable modulus in flexible pressure sensors,which are potentially useful in intelligent robots and health monitoring.

Improved symptoms following bumetanide treatment in children aged 3-6 years with autism spectrum disorder:a randomized,double-blind,placebo-controlled trial

With the current limited drug therapy for the core symptoms of autism spectrum disorder(ASD),we herein report a randomized,double-blind,placebo-controlled trial to investigate the efficacy,safety,and potential neural mechanism of bumetanide in children with ASD aged 3-6 years old.A total of 120 children were enrolled into the study and randomly assigned to either 0.5 mg bumetanide or placebo.In the final sample,119 children received at least one dose of bumetanide(59 children) or placebo(60 children) were included in the final analysis.The primary outcome was a reduction in the Childhood Autism Rating Scale(CARS) score,and the secondary outcomes were the Clinical Global Impressions Scale(CGI)-Global Improvement(CGI-I) score at 3 months and the change from baseline to 3-month in the Autism Diagnostic Observation Schedule(ADOS).Magnetic resonance spectroscopy(MRS) was used to measure y-aminobutyric acid(GABA) and glutamate neurotransmitter concentrations in the insular cortex(IC) before and after the treatment.As compared with the placebo,bumetanide treatment was significantly better in reducing the severity.No patient withdrew from the trial due to adverse events.The superiority of bumetanide to placebo in reducing insular GABA,measured using MRS,was demonstrated.The clinical improvement was associated with a decrease in insular GABA in the bumetanide group.In conclusion,this trial in a large group of young children with predominantly moderate and severe ASD demonstrated that bumetanide is safe and effective in improving the core symptoms of ASD.However,the clinical significance remains uncertain,and future multi-center clinical trials are required to replicate these findings and confirm the clinical significance using a variety of outcome measures.

Shanghai Autism Early Development:An Integrative Chinese ASD Cohort

Why Was the Cohort Set Up?Autism spectrum disorder(ASD)is a child neurodevelopmental disorder,the onset of which is generally within 3 years of age,and often leads to lifelong impaired social and cognitive functions,which impose significant mental pressure and economic burdens on the family and society.

Miniaturization of mechanical actuators in skin-integrated electronics for haptic interfaces

Skin-integrated electronics,also known as electronic skin(e-skin);are rapidly developing and are gradually being adopted in biomedical fields as well as in our daily lives.E-skin capable of providing sensitive and high-resolution tactile sensations and haptic feedback to the human body would open a new e-skin paradigm for closed-loop human-machine interfaces.Here,we report a class of materials and mechanical designs for the miniaturization of mechanical actuators and strategies for their integration into thin,soft e-skin for haptic interfaces.The mechanical actuators exhibit small dimensions of 5 mm diameter and 1.45 mm thickness and work in an electromagnetically driven vibrotactile mode with resonance frequency overlapping the most sensitive frequency of human skin.Nine mini actuators can be integrated simultaneously in a small area of 2 cm×2 cm to form a 3×3 haptic feedback array,which is small and compact enough to mount on a thumb tip.Furthermore,the thin,soft haptic interface exhibits good mechanical properties that work properly during stretching,bending,and twisting and therefore can conformally fit onto various parts of the human body to afford programmable tactile enhancement and Braille recognition with an accuracy rate over 85%.

SANTA： Self-aligned nanotrench ablation via Joule heating for probing sub-20 nm devices

Manipulating materials at the nanometer scale is challenging, particularly if alignment with nanoscale electrodes is desired. Here, we describe a lithography-free, self-aligned nanotrench ablation （SANTA） technique to create nanoscale ＂trenches＂ in a polymer like poly（methyl methacrylate） （PMMA）. The nanotrenches are self-aligned with carbon nanotube （CNT） or graphene ribbon electrodes through a simple Joule heating process. Using simulations and experiments we investigated how the Joule power, ambient temperature, PMMA thickness, and substrate properties affect the spatial resolution of this technique. We achieved sub-20 nm nanotrenches, for the first time, by lowering the ambient temperature and reducing the PMMA thickness. We also demonstrated a functioning nanoscale resistive memory （RRAM） bit self- aligned with a CNT control device, achieved through the SANTA approach. This technique provides an elegant and inexpensive method to probe nanoscale devices using self-aligned electrodes, without the use of conventional alignment or lithography steps.