深圳机场小型兽类组成、多样性及时空变化

野生动物与飞机撞击对全球航空业造成日益增加的风险和经济损失(DeVault et al.,2011;Blackwell et al.,2013;Metz et al.,2020)。据中国民用航空局(CAAC)统计《鸟击飞机信息分析报告》显示,鸟击事故从2007年的326起增加到2016年的4618起,造成严重的安全风险和经济损失(Hu et al.,2020)。

黑松露提取物紧致抗皱功效

采用成纤维细胞释放I型胶原蛋白、抑制弹性蛋白酶和抗糖化生化试验、斑马鱼尾鳍皱缩模型,探讨黑松露提取物的紧致抗皱功效。结果表明,黑松露提取物对小鼠胚胎成纤维细胞(3T3细胞)分泌I型胶原蛋白有显著促进作用,显著抑制弹性蛋白酶活性与抗糖化,显著抑制尾鳍皱缩(P<0.01)。综上,黑松露提取物有一定的紧致抗皱功效。

Study on Soothing and Oil Control Anti-acne Effects of Artemisia Annua Extract

Preliminary exploration of the soothing,oil control,acne removing effects and its mechanisms of Artemisia annua extract.The soothing effect of Artemisia annua extract was tested by hyaluronidase biochemical reaction.The soothing and oil-controlling effects were investigated by cell model.The inhibitory effect on propionibacterium acnes was studied by suspension quantification.The results showed that Artemisia annua extract could effectively inhibit the degradation of hyaluronic acid(P<0.01).Artemisia annua extract significantly inhibited the secretion of inflammatory cytokines TNF-αand IL-6 in RAW264.7 cells(P<0.05).Artemisia annua extract at 0.5%,0.25%,0.125%could significantly inhibit the secretion of oil by SZ95 cells(P<0.05).The minimum inhibitory concentration of Artemisia annua extract against propionibacterium acnes was 0.625%,and the inhibitory rate against propionibacterium acnes increased with the increase of the concentration of Artemisia annua extract.In summary,Artemisia annua extract can achieve acne efficacy through soothing and oil control,and this function may be achieved by reducing hyaluronic acid degradation,inhibiting inflammatory pathways produced by inflammatory factors TNF-αand IL-6,inhibiting oil secretion,and inhibiting the growth of propionibacterium acnes.

积雪草提取物舒缓与修护活性研究

采用细胞、透明质酸酶与人体临床实验,探讨积雪草提取物的舒缓与修护功效。细胞实验研究积雪草提取物对RAW264.7(小鼠巨噬细胞)分泌IL-6的影响,同时研究对HaCaT(人永生化表皮细胞)迁移的影响。通过抑制透明质酸酶活性评价积雪草提取物的舒缓效果。人体临床实验测试志愿者使用积雪草提取物精华液前后皮肤经皮水分流失TEWL值与皮肤含水量MMV值。积雪草提取物在0.003%、0.0015%时对IL-6浓度有明显抑制作用;体积浓度为0.2%、0.1%、0.05%的积雪草提取物能显著抑制透明质酸酶活性。100μg/mL的积雪草提取物对HaCaT细胞迁移有显著促进作用。人体临床实验表明精华液中添加0.1%的积雪草提取物与空白组相比,皮肤经皮失水TEWL值变化率为-37.86%(P<0.001),皮肤含水量MMV值变化率为65.09%(P<0.001)。

营养干预对肥胖、糖尿病机体糖脂代谢和肠道菌群的影响

肥胖、糖尿病都是代谢性疾病,会引起一系列并发症,严重危害人体健康。其病因可能是遗传和环境共同作用的结果,糖脂代谢和肠道菌群是其中的重要环境因素。糖脂代谢紊乱会引起肥胖、糖尿病,不当饮食也会导致患者的糖脂代谢紊乱加剧,通过人为改变糖类、脂肪和蛋白质的配比进行营养干预,可调节自身糖脂代谢水平以达到缓解病症和治疗的目的。此外,肥胖、糖尿病病人的肠道菌群多样性下降且功能紊乱,也是进一步维持和加剧病程的重要原因,而通过营养干预可促进肠道菌群多样性恢复及有益代谢物生成,对病症恢复起到较好作用。综述了肥胖、糖尿病与机体糖脂代谢和肠道菌群的相互作用关系,及营养干预对其的影响。