目的:现有研究显示,原发性痛风和高尿酸血症是一类多基因遗传性疾病,是遗传因素和环境因素共同作用的结果。但目前对痛风和高尿酸血症的遗传易感性研究尚不完善,还不能预测哪些人群易患痛风和高尿酸血症。全基因组关联分析(Genome-wide ...目的:现有研究显示,原发性痛风和高尿酸血症是一类多基因遗传性疾病,是遗传因素和环境因素共同作用的结果。但目前对痛风和高尿酸血症的遗传易感性研究尚不完善,还不能预测哪些人群易患痛风和高尿酸血症。全基因组关联分析(Genome-wide association study,GWAS)是近年来发展起来的用于识别、鉴定复杂性疾病致病易感基因的手段,通过对病人和正常对照人群的筛查,结合计算机技术和统计分析手段,可从整个基因组变异来识别、鉴定微效基因及其与相关疾病的相互作用。笔者对近几年发现的尿酸相关基因进行总结分类,为进一步认识痛风和高尿酸血症的分子机制提供依据,为进一步深入研究痛风和高尿酸血症的病因提供有益参考。展开更多
Objective:Existing studies have shown that primary gout and hyperuricemia are a group of polygenetic hereditary diseases,which are the results of the combination of genetic and environmental factors.However,the study ...Objective:Existing studies have shown that primary gout and hyperuricemia are a group of polygenetic hereditary diseases,which are the results of the combination of genetic and environmental factors.However,the study on the genetic susceptibility of gout and hyperuricemia is not yet complete and it is not yet possible to predict which populations are susceptible to gout and hyperuricemia.Genome-wide association study(GWAS),a method developed in recent years,is used to identify susceptibility genes for complex disease pathogenesis.Through screening patients and the normal control,and combined with computer technology and statistical analysis,genome-wide variation can be used to identify minor gene and its interaction with related diseases.In our study,we summarized and classified uric acid related genes discovered in recent years,so as to provide a basis for further understanding of the molecular mechanism of gout and hyperuricemia,and provide a beneficial reference for further study on the etiology of gout and hyperuricemia.展开更多
文摘目的:现有研究显示,原发性痛风和高尿酸血症是一类多基因遗传性疾病,是遗传因素和环境因素共同作用的结果。但目前对痛风和高尿酸血症的遗传易感性研究尚不完善,还不能预测哪些人群易患痛风和高尿酸血症。全基因组关联分析(Genome-wide association study,GWAS)是近年来发展起来的用于识别、鉴定复杂性疾病致病易感基因的手段,通过对病人和正常对照人群的筛查,结合计算机技术和统计分析手段,可从整个基因组变异来识别、鉴定微效基因及其与相关疾病的相互作用。笔者对近几年发现的尿酸相关基因进行总结分类,为进一步认识痛风和高尿酸血症的分子机制提供依据,为进一步深入研究痛风和高尿酸血症的病因提供有益参考。
基金This study was supported by the Project of Heilongjiang Natural Science Fund(Grant No.H201374)Basic Scientific Research Business Fee Project of Heilongjiang Provincial Universities(Grant No.2016-KYYWF-0591)Graduate Student Innovation Project of Jiamusi University(BC2016_001).
文摘Objective:Existing studies have shown that primary gout and hyperuricemia are a group of polygenetic hereditary diseases,which are the results of the combination of genetic and environmental factors.However,the study on the genetic susceptibility of gout and hyperuricemia is not yet complete and it is not yet possible to predict which populations are susceptible to gout and hyperuricemia.Genome-wide association study(GWAS),a method developed in recent years,is used to identify susceptibility genes for complex disease pathogenesis.Through screening patients and the normal control,and combined with computer technology and statistical analysis,genome-wide variation can be used to identify minor gene and its interaction with related diseases.In our study,we summarized and classified uric acid related genes discovered in recent years,so as to provide a basis for further understanding of the molecular mechanism of gout and hyperuricemia,and provide a beneficial reference for further study on the etiology of gout and hyperuricemia.
