Predictive Effect of CA125 on Adverse Cardiovascular Events in Patients with Chronic Heart Failure

Objective: To study the expression of CA125 in the serum of patients with CHF and the relationship between CA125 level and the occurrence of adverse cardiovascular events. Methods: The clinical data of 132 patients with CHF admitted to Shizuishan Second People’s Hospital from January 2023 to December 2023 were collected and divided into heart function II group, heart function III group, heart function IV group according to cardiac function. 44 healthy subjects who underwent physical examination during the same period were selected as the control group. The clinical data of CA125, NT-proBNP, echocardiography and other clinical data of the four groups were compared, and the incidence of major adverse cardiovascular events was followed up for 12 months. Results: Compared with the control group, the CA125 level in the CHF group was significantly increased (P Conclusion: Serum CA125 level is related to the cardiac function level in CHF patients and increases with the deterioration of cardiac function. The increase of the index is related to the mortality rate and re-hospitalization rate, suggesting that CA125 can be used as an indicator to reflect the severity of heart failure and prognosis monitoring.

硬性支撑联合带蒂鼻中隔黏膜瓣技术在垂体瘤术后鞍底重建中的应用

目的探讨硬性支撑联合带蒂鼻中隔黏膜瓣技术在垂体瘤术后鞍底重建中的应用。方法采用回顾性和观察性的研究方法收集2019年8月至2023年5月西安交通大学第一附属医院神经外科完成的54例经鼻蝶垂体瘤切除患者的临床资料,依据鞍底重建方式分为硬性支撑组和软性重建组,比较两组手术时间、脑脊液漏发生及住院时间等情况。结果两组手术时间及术中出血量比较,差异无统计学意义(P>0.05)。硬性支撑组的术后脑脊液漏发生率及腰大池置管率低于软性重建组,住院时间短于软性重建组(P<0.05)。结论硬性支撑联合带蒂鼻中隔黏膜瓣技术能有效减少经鼻蝶垂体瘤术后脑脊液漏的发生。

超声振动辅助研磨SiCp/Al材料去除特性的研究

SiCp/Al因具有高强度,低密度,高耐磨性等优点被应用在许多领域,如航空航天,汽车和电子领域等。但SiCp/Al是典型的难加工材料,在研磨过程中极易造成表面损伤,从而影响工件的表面精度和材料去除率。基于金属基复合材料的研磨去除机理,建立有限元仿真模型。仿真模拟超声去除SiCp/Al的表面损伤形式、颗粒的破碎方式与材料去除过程。通过超声振动辅助研磨SiCp/Al实验可知,超声振动能够有效降低表面粗糙度。材料去除率随主轴转速和研磨深度的增加而增大,随进给速度的增加而减小。

复杂行星表面着陆避障增广曲率制导方法

针对复杂行星表面安全着陆问题,提出避障增广曲率制导方法。在基本曲率制导律的基础上引入障碍规避增广项。该方法利用着陆器着陆空间区域划分的思想,在障碍附近易发生碰撞区域建立膨胀预警区,基于膨胀预警区推导连续解析的障碍规避制导律,在满足几何凸轨迹状态约束的同时,考虑着陆器与障碍的相对位置关系,能够快速引导着陆器远离障碍,提高着陆器着陆过程中的安全性。仿真结果表明,该方法能够有效规避复杂行星表面的地形障碍,实现在行星表面定点软着陆,具有良好的灵活性和可靠性。

赤芍抗炎活性的物质基础及作用机制研究进展

炎症是生物组织受到某种刺激,如外伤、感染等损伤因子的刺激所发生的一种以防御反应为主的基本病理过程,炎症的发展可能导致局部组织的变异和增生,从而进一步加速疾病发展。赤芍作为常用的中药材之一,具有清热凉血,散瘀止痛的功效。笔者通过综述近期国内外关于赤芍抗炎活性的物质基础及其作用机制的相关文献,发现赤芍中的萜类、挥发油、酚酸、黄酮类、鞣质等多种化学成分通过AMPK、MAPK、NF-κB、STAT6和HO-1信号通路发挥抗炎作用,从而治疗结肠炎、关节炎、乳腺炎和角膜炎等相关炎症疾病。

电子灸对遗忘型轻度认知障碍患者海马亚区体积的影响

背景:目前有研究表明,电子灸可以改善遗忘型轻度认知障碍患者的记忆功能,然而其作用机制有待进一步研究。海马体积萎缩和功能连接受损是遗忘型轻度认知障碍的重要影像学标志物,电子灸是否可以调节遗忘型轻度认知障碍患者的海马亚区体积值得研究。目的:观察电子灸对遗忘型轻度认知障碍患者海马区体积的影响。方法:于2018-04-01/2019-01-31在深圳大学第二附属医院(深圳市宝安人民医院)及下属社区服务中心与下属的社区招募遗忘型轻度认知障碍患者40例,采用随机数字表法分为治疗组与对照组,每组20例。治疗组接受调神益智电子灸治疗(艾灸温度45℃,每次20 min,1次/d,每周5次),对照组接受安慰灸治疗,持续治疗8周。治疗前及治疗结束后,利用MRI扫描海马亚区体积,采用Rivermead行为记忆测验(RBMT)量表、简易精神状态检查(MMSE)量表与蒙特利尔认知评估(MoCA)量表评估患者的认知功能,并分析海马亚区体积与各量表评分的相关性。结果与结论:①治疗结束后,治疗组患者海马左侧旁下托与左侧海马-杏仁核移行区体积增加,对照组患者海马左侧旁下托与左侧海马-杏仁核移行区体积减少,两组间海马左侧旁下托与左侧海马-杏仁核移行区体积变化值比较差异有显著性意义(P<0.05);②与治疗前比较,治疗组患者治疗结束后的RBMT、MMSE、MoCA量表评分均升高(P<0.05),对照组患者治疗结束后的3个量表评分无明显变化(P>0.05);治疗组患者治疗结束后的RBMT、MMSE、MoCA量表评分均高于对照组(P<0.05);③Pearson相关分析结果显示,治疗组左侧旁下托体积变化与RBMT量表评分呈显著正相关(r=0.418,P=0.014);④结果表明,电子灸可以改善遗忘型轻度认知障碍患者的记忆力,其机制可能是调节海马亚区结构的可塑性。

烟草叶片响应镉胁迫的差异表达基因鉴定及分析

烟草具有超富集镉的能力,严重降低烟叶品质,影响其经济价值。为了阐释烟草响应镉胁迫的分子机制,本研究采集了镉浓度为0和500μmol L^(–1)培养条件下的烟草叶片进行转录组测序。共获得76.94 Gb有效数据(Clean data),Q30碱基百分比均达到95.43%以上;在镉胁迫的烟草叶片中,共筛选出7735个差异表达基因,其中4833个基因表达上调,2902个基因表达下调,并通过qRT-PCR分析验证了转录组数据的可靠性。对差异转录本进行GO和KEGG富集分析,GO注释表明差异基因涉及代谢过程、应激反应、细胞结构体、催化活性和转录调节活性等;KEGG富集分析表明上调差异基因主要富集在氨基酸的生物合成、碳代谢、氧化磷酸化和柠檬酸循环等通路,下调差异基因则主要富集在光合作用、次生代谢产物的生物合成、代谢途径和植物激素信号转导途径。进一步分析植物激素信号转导通路发现,共有8条植物激素途径以不同的表达方式参与烟草对镉胁迫的响应。激素喷施烟草的实验结果表明,叶片通过调控赤霉素、油菜素内酯和茉莉酸途径以应对镉胁迫;拟南芥激素信号缺失突变体验证实验表明赤霉素、油菜素内酯、茉莉酸和乙烯途径均响应镉胁迫。综上所述,本文以转录组分析探究了烟草叶片响应镉胁迫的调控网络,以期为提高作物抗逆性的遗传改良提供理论依据。

重力场中油滴运动速度及聚合规律研究

由于油井中后期产量下降,注水开发技术得到广泛应用。为优化注入水水质、净化地层,需提高采出水中的油水分离效率。油水分离效率的高低取决于对油水两相运动规律的掌握及分离方法的正确应用。该研究在油滴运动理论的基础上,借助Fluent有限元模拟软件,对油滴在流场中的变形和聚并动态进行精细描述。通过实验测试重力场中黏度为5.7 mPa·s和54 mPa·s、直径为3.0~8.5 mm的油滴上升速度及其变形规律。研究结果表明:直径较大的油滴具有较大的加速度,并提前达到最大速度,其上浮过程中的变形系数随着油相黏度的增加逐渐增加。多个油滴的聚合及其速度主要受连续相的黏度变化影响。在原有油滴速度计算模型的基础上考虑了表面张力对油滴变形的影响,得到的新模型对油滴的速度计算误差为±7%,显著提高了油滴速度的计算精度。

针灸干预机体亚健康症状的运用与思考

当前机体亚健康者在人群中占比较高,亚健康向健康的转归主要取决于自身免疫水平和适时有效的干预措施。中医学素有治未病的理念,可指导针灸临床干预机体亚健康症状而预防疾病。从针灸干预机体亚健康症状的理论基础、临床运用和调节机制三个方面进行探讨,认为针灸可明显改善机体亚健康症状,并能通过调理偏颇体质纠偏却病。针灸调节作用具有整体性、双向性特点,针灸通过调节神经-内分泌-免疫网络,维持机体内环境稳态,刺灸信号从外周传入中枢进行整合,不会产生毒副作用。针灸作为传统中医学独具一格的非药物疗法,应在亚健康领域充分开发,未病先防,欲病救萌,防微杜渐,满足患者对健康的期待,并用现代科学方法研究其作用机制。

施工应力释放对单层衬砌内水承载能力影响研究

为探究施工应力释放对隧洞衬砌结构内水承载能力的影响,以扩大杭嘉湖南排后续西部通道工程为例,采用有限元法建立地层-结构精细模型,分析了不同施工应力释放率下,大断面水工TBM隧洞在软岩地层条件下其单层管片衬砌作为永久支护结构承受不同内水压力时的受力变形规律。结果表明:管片衬砌向外膨胀,管片拉应力、接缝张开量和螺栓应力均随着内水压力增大呈非线性阶跃增大特征;对于穿越Ⅴ类围岩的洞段,应综合考虑三者因素来判断是否达到正常使用极限状态,且衬砌内外压差不宜超过0.2MPa;较小施工应力释放率下的管片环间拼缝薄弱位置容易开裂,而过大施工应力释放率下的接缝张开量和螺栓应力容易达到正常使用极限状态。

Nitric oxide removal from flue gas coupled with the Fe^(Ⅱ)EDTA regeneration by ultraviolet irradiation

During wet complexation denitrification of flue gas,Fe^(Ⅱ)EDTA regeneration,also known as reducing Fe^(Ⅱ)EDTA and Fe^(Ⅱ)EDTA-nitric oxide(NO)to Fe^(Ⅱ)EDTA,is crucial.In this paper,ultraviolet(UV)light was used for the first time to reduce Fe^(Ⅱ)EDTA-NO.The experimental result demonstrated that Fe^(Ⅱ)EDTA-NO reduction rate increased with UV power increasing,elevated temperature,and initial Fe^(Ⅱ)EDTA-NO concentration decreasing.Fe^(Ⅱ)EDTA-NO reduction rate increased first and then decreased as pH value increased(2.0-10.0).Fe^(Ⅱ)EDTA-NO reduction with UV irradiation presented a first order reaction with respect to Fe^(Ⅱ)EDTA-NO.Compared with other Fe^(Ⅱ)EDTA regeneration methods,Fe^(Ⅱ)EDTA regeneration with UV show more superiority through comprehensive consideration of regeneration rate and procedure.Subsequently,NO absorption experiment by Fe^(Ⅱ)EDTA solution with UV irradiation confirmed that UV can significantly promote the NO removal performance of Fe^(Ⅱ)EDTA.Appropriate oxygen concentration(3%(vol))and acidic environment(pH=4)was favorable for NO removal.With UV power increasing as well as temperature decreasing,NO removal efficiency rose.In addition,the mechanism research indicates that NO from flue gas is mostly converted to NO_(2)-,NO_(3)-,NH_(4)^(+),N_(2),and N_(2)O with Fe^(Ⅱ)EDTA absorption liquid with UV irradiation.UV strengthens NO removal in Fe^(Ⅱ)EDTA absorption liquid by forming a synergistic effect of oxidation-reduction-complexation.Finally,compared with NO removal methods with Fe^(Ⅱ)EDTA,Fe^(Ⅱ)EDTA combined UV system shows prominent technology advantage in terms of economy and secondary pollution.

Hydrologic Response to Future Climate Change in the Dulong-Irra-waddy River Basin Based on Coupled Model Intercomparison Project 6

Within the context of the Belt and Road Initiative(BRI)and the China-Myanmar Economic Corridor(CMEC),the Dulong-Ir-rawaddy(Ayeyarwady)River,an international river among China,India and Myanmar,plays a significant role as both a valuable hydro-power resource and an essential ecological passageway.However,the water resources and security exhibit a high degree of vulnerabil-ity to climate change impacts.This research evaluates climate impacts on the hydrology of the Dulong-Irrawaddy River Basin(DIRB)by using a physical-based hydrologic model.We crafted future climate scenarios using the three latest global climate models(GCMs)from Coupled Model Intercomparison Project 6(CMIP6)under two shared socioeconomic pathways(SSP2-4.5 and SSP5-8.5)for the near(2025-2049),mid(2050-2074),and far future(2075-2099).The regional model using MIKE SHE based on historical hydrologic processes was developed to further project future streamflow,demonstrating reliable performance in streamflow simulations with a val-idation Nash-Sutcliffe Efficiency(NSE)of 0.72.Results showed that climate change projections showed increases in the annual precip-itation and potential evapotranspiration(PET),with precipitation increasing by 11.3%and 26.1%,and PET increasing by 3.2%and 4.9%,respectively,by the end of the century under SSP2-4.5 and SSP5-8.5.These changes are projected to result in increased annual streamflow at all stations,notably at the basin’s outlet(Pyay station)compared to the baseline period(with an increase of 16.1%and 37.0%at the end of the 21st century under SSP2-4.5 and SSP5-8.5,respectively).Seasonal analysis for Pyay station forecasts an in-crease in dry-season streamflow by 31.3%-48.9%and 22.5%-76.3%under SSP2-4.5 and SSP5-8.5,respectively,and an increase in wet-season streamflow by 5.8%-12.6%and 2.8%-33.3%,respectively.Moreover,the magnitude and frequency of flood events are pre-dicted to escalate,potentially impacting hydropower production and food security significantly.This research outlines the hydrological response to future climate change during the 21st century and offers a scientific basis for the water resource management strategies by decision-makers.

Two Monte Carlo-based simulators for imaging-system modeling and projection simulation of flat-panel X-ray source

The advantages of a flat-panel X-ray source(FPXS)make it a promising candidate for imaging applications.Accurate imaging-system modeling and projection simulation are critical for analyzing imaging performance and resolving overlapping projection issues in FPXS.The conventional analytical ray-tracing approach is limited by the number of patterns and is not applicable to FPXS-projection calculations.However,the computation time of Monte Carlo(MC)simulation is independent of the size of the patterned arrays in FPXS.This study proposes two high-efficiency MC projection simulators for FPXS:a graphics processing unit(GPU)-based phase-space sampling MC(gPSMC)simulator and GPU-based fluence sampling MC(gFSMC)simulator.The two simulators comprise three components:imaging-system modeling,photon initialization,and physical-interaction simulations in the phantom.Imaging-system modeling was performed by modeling the FPXS,imaging geometry,and detector.The gPSMC simulator samples the initial photons from the phase space,whereas the gFSMC simulator performs photon initialization from the calculated energy spectrum and fluence map.The entire process of photon interaction with the geometry and arrival at the detector was simulated in parallel using multiple GPU kernels,and projections based on the two simulators were calculated.The accuracies of the two simulators were evaluated by comparing them with the conventional analytical ray-tracing approach and acquired projections,and the efficiencies were evaluated by comparing the computation time.The results of simulated and realistic experiments illustrate the accuracy and efficiency of the proposed gPSMC and gFSMC simulators in the projection calculation of various phantoms.

深度学习对放疗影像进行盆腔肠管自动勾画的可行性研究

目的研究基于深度学习对放疗影像进行盆腔肠管自动勾画的可行性。方法随机选取2019—2021年在复旦大学附属中山医院接受放疗的直肠癌患者100例,随机选取其中60例作为训练模型病例,另40例作为测试病例。以手动肠管勾画为标准,基于深度学习自动分割软件AccuContour中的原始小肠模型,分别在60个模型病例中随机选取60、40、20(2组)个病例训练肠管勾画,获得4个训练模型Rec60、Rec40、Rec20A和Rec20B。使用40例测试病例评估原始模型与Rec60模型的Dice相似性系数(Dice similarity coefficient,DSC)、95%Hausdorff距离(95%Hausdorff distance,HD95)和平均对称表面距离(average symmetric surface distance,ASSD),并分别评估5组自动勾画的DSC。使用SPSS软件对几何参数进行配对t检验。结果训练后的勾画更接近手动勾画的肠管,能够较好地分辨肠管边界,可区分小肠与结肠。Rec60的平均DSC、HD95和ASSD分别较原始模型高0.16(P<0.001)、低12.4(P<0.001)和低5.14(P<0.001)。关于DSC,经配对t检验,4个训练模型与原始模型的差异均有统计学意义,Rec60与Rec40之间差异无统计学意义,Rec60和Rec40与Rec20A和Rec20B之间差异有统计学意义,Rec20A与Rec20B之间差异无统计学意义。结论对于放疗影像的自动勾画,模型训练能够有效提高肠管勾画的准确性。在AccuContour软件中40个及以上病例的训练集能够训练出盆腔肠管勾画的最优模型。

基于互信息及人工神经网络的降雨-径流预报方法

输入变量空间信息的提取、筛选与输入优化是提高数据驱动水文模型性能的关键环节。为提高数据驱动短期径流预报模型效果,以全国第二届水科学数值模拟创新大赛题目为算例,基于互信息及人工神经网络方法构建降雨-径流水文模型,进行小时尺度径流预报,探讨互信息对人工神经网络模型在降雨-径流预报精度提高上的作用。结果表明,基于互信息及人工神经网络的降雨-径流预报模型模拟精度高,适用性较好,验证期纳什效率系数和相关系数分别为0.94、0.96。互信息方法能够实现径流预报模型的输入优化,避免数据冗余,可为空间信息缺乏流域径流预报因子选择提供新思路。

Assessing environmental impact:Micro-energy network optimization in a Chinese industrial park

Micro-energy systems contribute significantly to environmental improvement by reducing dependence on power grids through the utilization of multiple renewable energy sources.This study quantified the environmental impact of a micro-energy network system in an industrial park through a life cycle assessment using the operation of the micro-energy network over a year as the functional unit and“cradle-to-gate”as the system boundary.Based on the baseline scenario,a natural gas generator set was added to replace central heating,and the light pipes were expanded to constitute the optimized scenario.The results showed that the key impact categories for both scenarios were global warming,fine particulate matter formation,human carcinogenic toxicity,and human non-carcinogenic toxicity.The overall environmental impact of the optimized scenario was reduced by 68%compared to the baseline scenario.A sensitivity analysis of the key factors showed that electricity from the power grid was the key impact factor in both scenarios,followed by central heating and natural gas.Therefore,to reduce the environmental impact of network systems,it is necessary to further optimize the grid power structure.The research approach can be used to optimize micro-energy networks and evaluate the environmental impact of different energy systems.

Circulating glycated albumin levels and gestational diabetes mellitus

BACKGROUND Gestational diabetes mellitus(GDM)is characterized by glucose intolerance that is first diagnosed during pregnancy,making it the most common complication associated with this period.Early detection and targeted treatment of GDM can minimize foetal exposure to maternal hyperglycaemia and subsequently reduce the associated adverse pregnancy outcomes.Previous studies have inconsistently suggested that the level of glycated albumin(GA)might predict GDM.AIM To review and synthesize existing evidence to evaluate the relationship between GA levels and the development of GDM.METHODS We sought to compare GA levels between GDM and control groups in this metaanalysis by systematically searching the Web of Science,PubMed,Cochrane Library,and Embase databases for articles published up to June 2023.The analysis utilized the weighted mean difference(WMD)as the primary metric.The data were meticulously extracted,and the quality of the included studies was assessed.Additionally,we conducted a subgroup analysis based on study region and sample size.We assessed heterogeneity using I2 statistics and evaluated publication bias through funnel plots.Additionally,trim-and-fill analysis was employed to detect and address any potential publication bias.RESULTS The meta-analysis included a total of 11 studies involving 5477 participants,comprising 1900 patients with GDM and 3577 control individuals.The synthesized results revealed a notable correlation between elevated GA levels and increased susceptibility to GDM.The calculated WMD was 0.42,with a 95%confidence interval(95%CI)ranging from 0.11 to 0.74,yielding a P value less than 0.001.Concerning specific GA levels,the mean GA level in the GDM group was 12.6,while for the control group,it was lower,at 11.6.This discrepancy underscores the potential of GA as a biomarker for assessing GDM risk.Moreover,we explored the levels of glycated haemoglobin(HbA1c)in both cohorts.The WMD for HbA1c was 0.19,with a 95%CI ranging from 0.15 to 0.22 and a P value less than 0.001.This observation suggested that both GA and HbA1c levels were elevated in individuals in the GDM group compared to those in the control group.CONCLUSION Our meta-analysis revealed a substantial correlation between elevated GA levels and increased GDM risk.Furthermore,our findings revealed elevated levels of HbA1c in GDM patients,emphasizing the significance of monitoring both GA and HbA1c levels for early GDM detection and effective management.

Research progress on venous thrombosis development in patients with malignant tumors

The coexistence of venous thromboembolism(VTE)within patients with cancer,known as cancer-associated thrombosis(CAT),stands as a prominent cause of mortality in this population.Over recent years,the incidence of VTE has demonstrated a steady increase across diverse tumor types,influenced by several factors such as patient management,tumor-specific risks,and treatment-related aspects.Furthermore,mutations in specific genes have been identified as potential contributors to increased CAT occurrence in particular cancer subtypes.We conducted an extensive review encompassing pivotal historical and ongoing studies on CAT.This review elucidates the risks,mechanisms,reliable markers,and risk assessment methodologies that can significantly guide effective interventions in clinical practice.

南充市饮用水源地水质总放射性水平分布特征与健康评价

为建立饮用水源地水体放射性水平基线,评估水体辐射安全状况,对2019年南充市9处饮用水源地水质总放射性水平进行了监测,分析了时空变化趋势,并估算了水体核素所致内照射年有效剂量,开展了种群患癌风险评估。结果表明,南充市饮用水源地水质总α、总β活度浓度范围分别为8.4~46.8mBq/L与37.9~168.7 mBq/L,数值时空变化趋势明显,与水体核素自然分布、水质环境、地表径流等因素有关。水体核素所致内照射年有效剂量估算的范围在4.39×10^(-2)~6.86×10^(-2)mSv/a,种群患癌风险几率的范围在2.41×10^(-6)~3.77×10^(-6)。分析得出,水质总放射性水平总体达标,剂量估算水平与患癌风险几率均处于正常水平,其数据可为应对环境突发事件、环境质量评价与水质指标预测评价提供依据。

丘陵山区水稻无人化农场应用及实践——以剑河县水稻无人农场为例分析

以生物技术、智能农机和信息技术为基础建立的水稻无化人农场,不仅是实现加快转变农业发展的重要方式,也是在探索现代农业发展道路上创造更多经验的重要途径。为加快推进贵州及周边丘陵山区水稻无人化农场的建设,在简单概括无人农场智能农机关键技术的基础上,对贵州省剑河县南明无人化农场的实施及应用情况进行了介绍,并对我国丘陵山区地带无人化农场发展的制约因素和其应用前景进行了分析,为打造丘陵山区水稻生产无人化农场示范基地,辐射带动周边现代农业机械化生产水平,引领全国农业转型升级提供参考。