Objective:To study the correlation of immune response and inflammatory response with human cartilage glycoprotein 39 (YKL-40) content in children with recurrent pneumonia. Methods: Children who were treated in the Cen...Objective:To study the correlation of immune response and inflammatory response with human cartilage glycoprotein 39 (YKL-40) content in children with recurrent pneumonia. Methods: Children who were treated in the Central Hospital of Enshi Autonomous Prefecture due to recurrent pneumonia between May 2014 and October 2017 were selected as the experimental group A of the research, children who were treated in the Central Hospital of Enshi Autonomous Prefecture due to acute pneumonia during the same period were selected as the experimental group B of the study, and children who received physical examination in the Central Hospital of Enshi Autonomous Prefecture during the same period were selected as the control group. Serum was collected to determine the contents of YKL-40, immune molecules and inflammatory molecules, and peripheral blood was collected to determine the expression of immune molecules and inflammatory molecules.Results: Serum YKL-40, IFN-γ, HMGB1, TNF-α, MCP4 and CysLTs levels as well as peripheral blood TLR4 and NF-κB expression intensity of experiment group A and experiment group B were higher than those of control group whereas peripheral blood TIM1, TIM3 and CD19 expression intensity as well as serum IL-4 levels were lower than those of control group, and the change of above indexes in experimental group A was more significant than that in experimental group B;peripheral blood TIM1, TIM3 and CD19 expression intensity as well as serum IL-4 level of experimental group A with high YKL-40 were significantly lower than those of experimental group A with low YKL-40 whereas serum IFN-γ, HMGB1, TNF-α, MCP4 and CysLTs levels as well as peripheral blood TLR4 and NF-κB expression intensity were significantly higher than those of experimental group A with low YKL-40.Conclusions: The abnormal secretion of YKL-40 in children with recurrent pneumonia is closely related to the disorder of immune response and the exceissive activation of inflammatory response.展开更多
文摘Objective:To study the correlation of immune response and inflammatory response with human cartilage glycoprotein 39 (YKL-40) content in children with recurrent pneumonia. Methods: Children who were treated in the Central Hospital of Enshi Autonomous Prefecture due to recurrent pneumonia between May 2014 and October 2017 were selected as the experimental group A of the research, children who were treated in the Central Hospital of Enshi Autonomous Prefecture due to acute pneumonia during the same period were selected as the experimental group B of the study, and children who received physical examination in the Central Hospital of Enshi Autonomous Prefecture during the same period were selected as the control group. Serum was collected to determine the contents of YKL-40, immune molecules and inflammatory molecules, and peripheral blood was collected to determine the expression of immune molecules and inflammatory molecules.Results: Serum YKL-40, IFN-γ, HMGB1, TNF-α, MCP4 and CysLTs levels as well as peripheral blood TLR4 and NF-κB expression intensity of experiment group A and experiment group B were higher than those of control group whereas peripheral blood TIM1, TIM3 and CD19 expression intensity as well as serum IL-4 levels were lower than those of control group, and the change of above indexes in experimental group A was more significant than that in experimental group B;peripheral blood TIM1, TIM3 and CD19 expression intensity as well as serum IL-4 level of experimental group A with high YKL-40 were significantly lower than those of experimental group A with low YKL-40 whereas serum IFN-γ, HMGB1, TNF-α, MCP4 and CysLTs levels as well as peripheral blood TLR4 and NF-κB expression intensity were significantly higher than those of experimental group A with low YKL-40.Conclusions: The abnormal secretion of YKL-40 in children with recurrent pneumonia is closely related to the disorder of immune response and the exceissive activation of inflammatory response.
