Clinical implications of the latest advances in gastrointestinal tumor research

In this editorial,we provide commentary on six articles recently published in the World Journal of Gastrointestinal Oncology.These articles collectively present the latest findings in the field of gastric and colorectal cancer(CRC)research.The global incidence of gastric cancer varies based on geographical location,age,and sex.The disease predominantly affects middle-aged and elderly individuals,with a slightly higher prevalence in men than in women.CRC is characterized by a low 5-year survival rate and high mortality rate.It primarily affects individuals over the age of 50,and the risk of disease increases with age.Both gastric and CRC pose significant health threats,thus requiring more effective diagnostic,therapeutic,and supportive care strategies to improve patient outcomes.The articles discussed in this editorial encompass topics such as screening,diagnosis,mechanisms of progression,and postoperative recovery in gastric and CRC,and the findings offer valuable insights for clinical decision-making in the diagnosis,treatment,and prognosis of gastrointestinal cancers.

Development of component stiffness equations for thread-fixed one-side bolt connections to an enclosed rectangular hollow section column under tension

The derivation and validation of analytical equations for predicting the tensile initial stiffness of threadfixed one-side bolts(TOBs),connected to enclosed rectangular hollow section(RHS)columns,is presented in this paper.Two unknown stiffness components are considered:the TOBs connection and the enclosed RHS face.First,the trapezoidal thread of TOB,as an equivalent cantilevered beam subjected to uniformly distributed loads,is analyzed to determine the associated deformations.Based on the findings,the thread-shank serial-parallel stiffness model of TOB connection is proposed.For analysis of the tensile stiffness of the enclosed RHS face due to two bolt forces,the four sidewalls are treated as rotation constraints,thus reducing the problem to a two-dimensional plate analysis.According to the load superposition method,the deflection of the face plate is resolved into three components under various boundary and load conditions.Referring to the plate deflection theory of Timoshenko,the analytical solutions for the three deflections are derived in terms of the variables of bolt spacing,RHS thickness,height to width ratio,etc.Finally,the validity of the above stiffness equations is verified by a series of finite element(FE)models of T-stub substructures.The proposed component stiffness equations are an effective supplement to the component-based method.

Snare-tip-assisted peroral endoscopic myotomy for achalasia(with video)

Introduction Since peroral endoscopic myotomy(POEM)for the treatment of achalasia was first introduced by Inoue et al.[1]in 2010,various endoscopic knives including the Triangular-tip knife have been used during the procedure[2].To date,the investigation on endoscopic knives with good performance and low expense is still underway for patients with achalasia.In this case,we successfully carried out POEMassisted by a snare tip in a patient with achalasia.