基金The researches described in this article were partially supported by grants from the National Natural Science Foundation of China (No. 81570271 and 81400357) and NIH (UL1 RR024996). We are very grateful to John R Lee (Assistant Professor of Medicine, Weill Comell Medical College, New York), and Jeff J Zhu (Research Manager, Weill Comell Medical College, New York) for critical review of the article. The authors have nothing to disclosure.