Mineral Resource Science in China:Review and perspective

Mineral resources are essential to prosperity and security of modern societies.How mineral resources can guar-antee sustainable development of economy in countries,especially those developing countries,has long been a focus of attention of international communities.This paper provides a comprehensive summary for major ad-vance of the research on mineral resources in past decades,and proposes some key issues regarding ore-forming mechanism,exploration and utilization of major and critical mineral resources.On the basis of these aspects,we also identify four priority science issues to be addressed in the future,including(1)mechanism of both metal circulation and extremely high concentration,(2)theories and technologies of prospecting deep-earth resources,(3)investigation of mineral resources in seafloor and polar regions,and(4)efficient,clean and recycling utiliza-tion of mineral resources.It can be expected that new advances in these four issues would tremendously promote the innovation of mineral resource science,and provide scientific and technologic support to meet the demand of mineral resources for human activities and the harmonious development of both mineral-resource exploration and ecological restoration.

Spatial variations of Pb,As,and Cu in surface snow along the transect from the Zhongshan Station to Dome A,East Antarctica

The spatial distributions of lead, arsenic, and copper （Pb, As, and Cu, respectively） in surface snow along the transect from the Zhongshan Station to Dome A, East Antarctica, are presented. The mean concentrations of Pb, As, and Cu are 1.04±1.56 pg/g, 0.39±0.08 pg/g, and 11.2±14.4 pg/g, respectively. It is estimated that anthropogenic contributions are dominant for Pb, As, and Cu. Spatially, Pb concentrations show an exponentially decreasing trend from the coast inland, while a moderate decreasing trend is observed for Cu concentrations in the coastal area （below 2,000 m above sea level （a.s.1.））. In the intermediate area （2,000-3,000 m a.s.1.）, the concentrations and enrichment factors of all these elements show high variability due to the complicated characteristics of climate and environment. On the inland plateau （above 3,000 m a.s.1.）, the high concentrations of As and Pb are induced by high deposition efficiency, the existence of polar stratospheric precipitation, and the different fraction deposition to East Antarctica. The extremely high concentrations with maximum values of 9.59 pg/g and 69.9 pg/g for Pb and Cu, respectively, are suggested to result mainly from local human activities at the station. Our results suggest that source, transport pathway, and deposition pattern, rather than distance from the coast or altitude, lead to the spatial distributions of Pb, As, and Cu; and it is further confirmed by spatial variations of the three metals deposited over the whole continent of Antarctica.

Peptide RL-QN15 promotes wound healing of diabetic foot ulcers through p38 mitogen-activated protein kinase and smad3/miR-4482-3p/vascular endothelial growth factor B axis

Background:Wound management of diabetic foot ulcers(DFUs)is a complex and challenging task,and existing strategies fail to meet clinical needs.Therefore,it is important to develop novel drug candidates and discover new therapeutic targets.However,reports on peptides as molecular probes for resolving issues related to DFUs remain rare.This study utilized peptide RL-QN15 as an exogenous molecular probe to investigate the underlying mechanism of endogenous non-coding RNA in DFU wound healing.The aim was to generate novel insights for the clinical management of DFUs and identify potential drug targets.Methods:We investigated the wound-healing efficiency of peptide RL-QN15 under diabetic con-ditions using in vitro and in vivo experimental models.RNA sequencing,in vitro transfection,quantitative real-time polymerase chain reaction,western blotting,dual luciferase reporter gene detection,in vitro cell scratches,and cell proliferation and migration assays were performed to explore the potential mechanism underlying the promoting effects of RL-QN15 on DFU repair.Results:Peptide RL-QN15 enhanced the migration and proliferation of human immortalized keratinocytes(HaCaT cells)in a high-glucose environment and accelerated wound healing in a DFU rat model.Based on results from RNA sequencing,we defined a new microRNA(miR-4482-3p)related to the promotion of wound healing.The bioactivity of miR-4482-3p was verified by inhibiting and overexpressing miR-4482-3p.Inhibition of miR-4482-3p enhanced the migration and proliferation ability of HaCaT cells as well as the expression of vascular endothelial growth factor B(VEGFB).RLQN15 also promoted the migration and proliferation ability of HaCaT cells,and VEGFB expression was mediated via inhibition of miR-4482-3p expression by the p38 mitogen-activated protein kinase(p38MAPK)and smad3 signaling pathways.Conclusions:RL-QN15 is an effective molecule for the treatment of DFUs,with the underlying mechanism related to the inhibition of miR-4482-3p expression via the p38MAPK and smad3 signaling pathways,ultimately promoting re-epithelialization,angiogenesis and wound healing.This study provides a theoretical basis for the clinical application of RL-QN15 as a molecular probe in promoting DFU wound healing.

The tidal signals extraction from GPS data on the Amery Ice Shelf, Antarctica

Tidal motion is the source of short-term vertical motion that an ice shelf experiences, and hence has a significant impact on ice shelves. During the 2003/2004 Austral summer season, five days of GPS measurements were carried out on the front of the Amery Ice Shelf （AIS）, East Antarctica, by the 20th Chinese National Antarctica Research Expedition （CHINARE）. The GPS data was processed using GAMIT/GLOBK software with 2-hour static data segment and the vertical precision is less than 0.18 m. To verify our results for the vertical component, we compare the ice shelf GPS tidal signal with a tidal result derived from tide gauge measurements at China＇s Zhongshan Station on Antarctica. Comparison of the GPS results with the tide gauge were in good agreement in amplitude at the few cm level, which indicates that the tide under the front of Amery Ice Shelf is irregular semidiurnal tide, the maximal tidal differences is approximately 2 m. GPS data can be used to validate the ocean tide model around the Antarctic area and such studies are important to improve our knowledge of the Antarctic ice shelf mass balance and dynamical models of ice sheet/ocean interaction.