Microscopic colitis(MC)is a chronic inflammatory disease of the large intestine and as a relatively late recognized condition,its relationship with other disorders of the gastrointestinal tract is gradually being unde...Microscopic colitis(MC)is a chronic inflammatory disease of the large intestine and as a relatively late recognized condition,its relationship with other disorders of the gastrointestinal tract is gradually being understood and investigated.As a multifactorial disease,MC interacts with inflammatory bowel disease,celiac disease,and irritable bowel syndrome through genetic overlap,immunological factors,and gut microflora.The risk of colorectal cancer was significantly lower in MC,gastrointestinal infections increased the risk of developing MC,and there was an inverse association between Helicobacter pylori infection and MC.A variety of associations are found between MC and other gastrointestinal disorders,where aspects such as genetic effects,resemblance of immunological profiles,and intestinal microecology are potential mechanisms behind the relationships.Clinicians should be aware of these connections to achieve a better understanding and management of MC.展开更多
文摘Microscopic colitis(MC)is a chronic inflammatory disease of the large intestine and as a relatively late recognized condition,its relationship with other disorders of the gastrointestinal tract is gradually being understood and investigated.As a multifactorial disease,MC interacts with inflammatory bowel disease,celiac disease,and irritable bowel syndrome through genetic overlap,immunological factors,and gut microflora.The risk of colorectal cancer was significantly lower in MC,gastrointestinal infections increased the risk of developing MC,and there was an inverse association between Helicobacter pylori infection and MC.A variety of associations are found between MC and other gastrointestinal disorders,where aspects such as genetic effects,resemblance of immunological profiles,and intestinal microecology are potential mechanisms behind the relationships.Clinicians should be aware of these connections to achieve a better understanding and management of MC.
