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Translocation and transformation of engineered nanomaterials in plant cells and their effect on metabolism
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作者 WEICHEN ZHAO PINGFAN ZHOU +5 位作者 BENZHEN LOU YAQI JIANG yuanbo li MINGSHU li NOMAN SHAKOOR YUKUI RUI 《BIOCELL》 SCIE 2023年第3期493-502,共10页
As the climate worsens and the demand for food grows,so does the interest in nanoagriculture.The interaction between plants and nanomaterials(NMs)has been extensively and intensively examined.However,stopping at the o... As the climate worsens and the demand for food grows,so does the interest in nanoagriculture.The interaction between plants and nanomaterials(NMs)has been extensively and intensively examined.However,stopping at the outcome of a phenomenon is often insufficient.Therefore,we introduce three important processes of nanoparticleplant interactions:translocation,transformation,and plant metabolism.During the migration of nanoparticles,size and surface electrical properties are the main determining factors.Additionally,the interaction of nanoparticles with cell membranes is another key aspect of research.The transformation of nanoparticles in plants is mainly due to redox substances.The way that nanoparticles affect plant metabolism may be able to shed light on the interaction of nanoparticles with plants.This review adds to the existing knowledge on the design of nanoagrochemicals and summarizes the mechanism of interaction of NMs with plants.In this way,NMs can be used for their beneficial effects and thus contribute to the maintenance of food security and sustainable development. 展开更多
关键词 Interaction Nanoagriculture Nanoparticles INTERNALIZATION
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3D-CTBA结合灌注区识别技术在单孔胸腔镜复杂肺段切除术中的应用 被引量:3
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作者 李元博 张毅 +2 位作者 支修益 苏雷 刘宝东 《中国肺癌杂志》 CAS CSCD 北大核心 2023年第1期17-21,共5页
背景与目的随着肺段切除术在早期肺癌治疗中的广泛应用,如何更加精准和微创地完成肺段切除成为研究热点。本研究旨在探讨三维计算机断层支气管血管成像(three-dimensional computed tomography bronchography and angiography,3D-CTBA)... 背景与目的随着肺段切除术在早期肺癌治疗中的广泛应用,如何更加精准和微创地完成肺段切除成为研究热点。本研究旨在探讨三维计算机断层支气管血管成像(three-dimensional computed tomography bronchography and angiography,3D-CTBA)结合灌注区识别技术在单孔胸腔镜复杂肺段切除术中的应用价值。方法回顾性分析2021年1月-2022年1月首都医科大学宣武医院胸外科单诊疗组连续112例单孔胸腔镜复杂肺段切除术患者的资料,总结采用三维重建结合灌注区识别技术完成手术并分析其临床数据。结果本组病例平均手术时间为(141.1±35.4)min,段间界显示初始时间为(12.5±1.7)s,段间界维持时间为(114.3±10.9)s,肺段间界均清晰显示(100%),出血量为[10(10,20)]m L,术后总引流量为(380.5±139.7)m L,术后拔管时间为(3.9±1.2)d,术后住院时间为(5.2±1.6)d。8例出现术后并发症。结论3D-CTBA结合灌注区识别技术在单孔胸腔镜复杂肺段切除术中对段间界识别具有快速、准确和安全的优点,为精准切除肿瘤、减少手术时间及降低手术并发症提供指导。 展开更多
关键词 肺肿瘤 单孔胸腔镜 肺段切除术 段间界 灌注区 识别技术
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Diagnosis of the surface morphology of laser-ablated materials using the weightedDCT approach in laser speckle interferometry for application to plasma facing materials
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作者 李元博 王宏北 +3 位作者 崔晓倩 李树华 赵栋烨 丁洪斌 《Plasma Science and Technology》 SCIE EI CAS CSCD 2019年第9期122-131,共10页
To implement on-line, real-time monitoring for the surface morphology of Plasma-Facing Materials(PFMs) in tokamak, we developed a Laser Speckle Interferometry measurement approach. A laser ablation method was used to ... To implement on-line, real-time monitoring for the surface morphology of Plasma-Facing Materials(PFMs) in tokamak, we developed a Laser Speckle Interferometry measurement approach. A laser ablation method was used to simulate the erosion process during Plasma-Wall Interactions in a tokamak. In the present investigation, we evaluated the results of laser ablation morphology changes on the surface of Mo material reconstructed by four different approaches(Flood-fill, Quality-guided, Discrete Cosine Transform(DCT) and Weighted-DCT). The morphology results measured by the weighted-DCT approach are very close to the measurement results from confocal microscopy with an average error rate within 7%. It is verified that the weighted-DCT algorithm has high accuracy and can efficiently reduce the influence of noise pollution coming from laser ablation, which is used as a proxy for erosion from plasma wall interaction. Additionally, the CPU computer time has been shortened. This is of great significance for the real-time monitoring of PFMs’ morphology in the Experimental Advanced Superconducting Tokamak(EAST) in the future. 展开更多
关键词 TOKAMAK fusion plasma-wall INTERACTIONS LASER SPECKLE INTERFEROMETRY topographical reconstruction algorithms
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Discussion on Chinese Ancient Literature Translation Based on the English Translation of the Book of Songs
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作者 Shuai Wu Xiuzhang Yang +2 位作者 Huan Xia yuanbo li Xiaohong He 《Review of Educational Theory》 2020年第2期28-31,共4页
The Book of Songs is an important part of Chinese traditional culture and enjoys a high reputation at home and abroad.This article is based on Turi’s theory of translation norms,and takes the English translation of T... The Book of Songs is an important part of Chinese traditional culture and enjoys a high reputation at home and abroad.This article is based on Turi’s theory of translation norms,and takes the English translation of The Book of Songs·Jing Jing by Richard Jacob and Xu Yuanchong as the research object.Comparative studies are made on the historical nature of understanding,the normativeness of translation,and the application of the fusion of horizons in the two versions of the Book of Songs.Incorporating history into translation brings the translation closer to the roots of history.The comparative research method proposed in this article can be widely used in various ancient literature studies,and has important theoretical and application values. 展开更多
关键词 The Book of Songs TRANSLATION HISTORY Ancient literature Fusion of horizons
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肺部小病灶经皮穿刺活检41例分析 被引量:5
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作者 胡牧 刘磊 +2 位作者 钱坤 李元博 支修益 《中国肺癌杂志》 CAS CSCD 北大核心 2018年第9期682-685,共4页
背景与目的近年来由于肺癌筛查工作的广泛开展,越来越多的肺部小病灶被发现,本研究旨在分析计算机断层扫描(computed tomography, CT)引导下经皮肺小病灶(直径<2 cm)穿刺活检结果及并发症、预后。方法选择2015年1月-2017年12月期间... 背景与目的近年来由于肺癌筛查工作的广泛开展,越来越多的肺部小病灶被发现,本研究旨在分析计算机断层扫描(computed tomography, CT)引导下经皮肺小病灶(直径<2 cm)穿刺活检结果及并发症、预后。方法选择2015年1月-2017年12月期间行CT引导下经皮肺穿刺活检术41例肺内周围型病灶,单发病灶39例多发病灶2例,病灶最大径5-20(13.1±5.2)mm。病灶距离肺表面深度1-45(16.5±13.7)mm,毛玻璃样成分(ground glass opacity, GGO)比例0%-100%(66.8%±35.2%)。结果 41例患者进行43次穿刺。43次穿刺均成功取得病理组织。手术证实其中非典型腺瘤样增生(atypical adenomatous hyperplasia, AAH)3例,鳞癌1例,腺癌37例(原位癌7例,微侵润癌5例,侵润性25例,有2例患者为双原发癌),炎性病变2例。除2例炎性病变正在随访中,活检与手术病理吻合度(特异性)为100%。气胸22例,发生率51.2%,需闭式引流2例,17例发生咯血,发生率39.5%,均为自限性。2例出现颅内空气栓塞经治疗痊愈,发生率4.6%。结论对于肺部小病灶CT引导经皮穿刺技术上可行。但对于肺部小病灶尤其是纯GGO的穿刺活检,目前还需要持谨慎态度。 展开更多
关键词 肺部 小病灶 活检
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奥希替尼联合贝伐珠单抗在获得性EGFR T790M突变晚期非小细胞肺癌的疗效分析 被引量:2
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作者 顾艳斐 田笑如 +4 位作者 王若天 李小雪 钱坤 李元博 农靖颖 《中国肺癌杂志》 CAS CSCD 北大核心 2022年第12期843-851,共9页
背景与目的奥希替尼是对表皮生长因子受体(epidermal growth factor receptor,EGFR)T790M突变非小细胞肺癌(non-small cell lung cancer,NSCLC)有效的第三代靶向药物。尽管第一代EGFR酪氨酸激酶抑制剂(EGFRtyrosine kinase inhibitors,E... 背景与目的奥希替尼是对表皮生长因子受体(epidermal growth factor receptor,EGFR)T790M突变非小细胞肺癌(non-small cell lung cancer,NSCLC)有效的第三代靶向药物。尽管第一代EGFR酪氨酸激酶抑制剂(EGFRtyrosine kinase inhibitors,EGFR-TKIs)联合贝伐珠单抗治疗可延长无进展生存期(progression-free survival,PFS),但奥希替尼联合贝伐珠单抗的后线疗效在II期研究WJOG8715L中并未得到肯定,目前该联合模式在中国人群中的数据仍非常有限。本研究旨在分析真实世界中奥希替尼联合贝伐珠单抗二线治疗的疗效,评价奥希替尼联合抗血管治疗模式在EGFR T790M获得性耐药突变NSCLC中的二线治疗价值。方法收集2020年1月-2021年8月收治的第一、二代EGFR-TKIs治疗后伴EGFR T790M突变NSCLC患者共42例。16例接受二线奥希替尼联合贝伐珠单抗治疗,另26例接受二线奥希替尼单药治疗。分析患者的治疗效果。结果联合组和单药组客观缓解率(objective response rate,ORR)相当(43.8%vs 50.0%,P=0.694)。两组中位PFS(14.0个月vs 13.0个月,P=0.797)和总生存期(overall survival,OS)(29.0个月vs 26.0个月,P=0.544)均未见统计学差异。Cox回归模型显示前线联合贝伐珠单抗治疗是奥希替尼后线单药或联合治疗PFS(P=0.045)及OS(P=0.023)更短的独立预测因素。结论奥希替尼联合贝伐珠单抗二线治疗相比靶向单药治疗未见更好的疗效。 展开更多
关键词 肺肿瘤 表皮生长因子受体 血管内皮生长因子 奥希替尼 贝伐珠单抗
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Campus Economic Analysis Based on K-Means Clustering and Hotspot Mining
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作者 Xiuzhang Yang Shuai Wu +2 位作者 Huan Xia yuanbo li Xin li 《Review of Educational Theory》 2020年第2期42-50,共9页
With the advent of the era of big data and the development and construction of smart campuses,the campus is gradually moving towards digitalization,networking and informationization.The campus card is an important par... With the advent of the era of big data and the development and construction of smart campuses,the campus is gradually moving towards digitalization,networking and informationization.The campus card is an important part of the construction of a smart campus,and the massive data it generates can indirectly reflect the living conditions of students at school.In the face of the campus card,how to quickly and accurately obtain the information required by users from the massive data sets has become an urgent problem that needs to be solved.This paper proposes a data mining algorithm based on K-Means clustering and time series.It analyzes the consumption data of a college student’s card to deeply mine and analyze the daily life consumer behavior habits of students,and to make an accurate judgment on the specific life consumer behavior.The algorithm proposed in this paper provides a practical reference for the construction of smart campuses in universities,and has important theoretical and application values. 展开更多
关键词 Machine learning K-Means clustering Data mining Consumer behavior Campus economy Economic regionalization
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Bleomycin inhibits CLEC14A to attenuate the progression of extracranial arteriovenous malformations
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作者 Congzhen Qiao Yajing Qiu +4 位作者 Yun Zou Chen Hua yuanbo li Yunbo Jin Xiaoxi lin 《Chinese Journal Of Plastic and Reconstructive Surgery》 2021年第4期175-180,共6页
Background:We previously reported that interstitial injection of bleomycin(BLM)reduces the size of early-stage extracranial arteriovenous malformation(AVM).Here,we sought to investigate the potential mechanism of BLM ... Background:We previously reported that interstitial injection of bleomycin(BLM)reduces the size of early-stage extracranial arteriovenous malformation(AVM).Here,we sought to investigate the potential mechanism of BLM in treating extracranial AVM.Methods:Samples of human extracranial AVM(n=3)with no pharmacological treatment were harvested.AVM endothelial cells were isolated and cultured in primary cell culture.The transcriptome was examined using RNAsequencing,and differentially expressed C-type lectin domain family 14 member A(CLEC14A)was validated at the transcriptomic and protein levels.Immunocytochemical staining of CLEC14A was performed in samples of human extracranial AVM,with and without BLM treatment.Results:Through second-generation sequencing,we found that the expression of 5689 genes were differentially increased or decreased following 24-h BLM stimulation.We found that CLEC14A may play an important role in the progression of AVM and can be inhibited by BLM treatment.Conclusion:BLM inhibited CLEC14A expression to attenuate the progression of AVM. 展开更多
关键词 BLEOMYCIN Extracranial arteriovenous malformation CLEC14A RNA-Sequencing
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Reimagining safe lithium applications in the living environment and its impacts on human,animal,and plant system
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作者 Noman Shakoor Muhammad Adeel +11 位作者 Muhammad Arslan Ahmad Muhammad Zain Usman Waheed Rana Arsalan Javaid Fasih Ullah Haider Imran Azeem Pingfan Zhou yuanbo li Ghulam Jilani Ming Xu Jorg Rinklebe Yukui Rui 《Environmental Science and Ecotechnology》 SCIE 2023年第3期1-13,共13页
Lithium's(Li)ubiquitous distribution in the environment is a rising concern due to its rapid proliferation in the modern electronic industry.Li enigmatic entry into the terrestrial food chain raises many questions... Lithium's(Li)ubiquitous distribution in the environment is a rising concern due to its rapid proliferation in the modern electronic industry.Li enigmatic entry into the terrestrial food chain raises many questions and uncertainties that may pose a grave threat to living biota.We examined the leverage existing published articles regarding advances in global Li resources,interplay with plants,and possible involvement with living organisms,especially humans and animals.Globally,Li concentration(<10 e300 mg kg1)is detected in agricultural soil,and their pollutant levels vary with space and time.High mobility of Li results in higher accumulation in plants,but the clear mechanisms and specific functions remain unknown.Our assessment reveals the causal relationship between Li level and biota health.For example,lower Li intake(<0.6 mM in serum)leads to mental disorders,while higher intake(>1.5 mM in serum)induces thyroid,stomach,kidney,and reproductive system dysfunctions in humans and animals.However,there is a serious knowledge gap regarding Li regulatory standards in environmental compartments,and mechanistic approaches to unveil its consequences are needed.Furthermore,aggressive efforts are required to define optimum levels of Li for the normal functioning of animals,plants,and humans.This review is designed to revitalize the current status of Li research and identify the key knowledge gaps to fight back against the mountainous challenges of Li during the recent digital revolution.Additionally,we propose pathways to overcome Li problems and develop a strategy for effective,safe,and acceptable applications. 展开更多
关键词 LITHIUM Plants health Soil ecology Domestic and aquatic animals Human health Threshold levels
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Extraction of straight field roads between farmlands based on agricultural vehicle-mounted LiDAR 被引量:1
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作者 lili Yang Yuanyuan Xu +7 位作者 Yajie liang Jia Qin yuanbo li Xinxin Wang Weixin Zhai Long Wen Zhibo Chen Caicong Wu 《International Journal of Agricultural and Biological Engineering》 SCIE CAS 2022年第5期155-162,共8页
The application of autonomous agricultural vehicles is gaining popularity as a way to increase production efficiency and lower operational costs.To achieve high performance,perception tasks(such as obstacle detection,... The application of autonomous agricultural vehicles is gaining popularity as a way to increase production efficiency and lower operational costs.To achieve high performance,perception tasks(such as obstacle detection,road extraction,and drivable area extraction)are of great importance.Compared with structured roads,field roads between farmlands,including unstructured roads and semi-structured roads,are unfavorable for autonomous agricultural vehicle driving due to their bumpiness and unstructured nature.This study proposed an extraction method for the straight field roads between farmlands.The proposed method was based on the point cloud data acquired by LiDAR(Velodyne VLP-16)mounted on a John Deere 12046B-1204 tractor.The proposed method has three aspects:Euclidean Clustering-based extraction,boundary-based extraction,and road point cloud curve segment modification.Firstly,Euclidean Clustering with K-Dimensional(KD)-Tree data structure was adopted to extract the road curve segments close to the LiDAR composed of road points.Secondly,the boundary lines constraint was constructed to extract the distant road curve segments.Thirdly,the local distance ratio was used to modify the extracted road curve segments.The average extraction accuracy for both semi-structured and unstructured roads exceeded 98%,and the false positive rate(FPR)was less than 0.5%.These experimental findings demonstrated that the proposed road extraction method was precise and effective.The proposed method of this study can be applied to enhance the perception ability of autonomous agricultural vehicles thereby increasing the efficiency and safety of field road driving. 展开更多
关键词 road extraction straight field road autonomous agricultural vehicle LIDAR FARMLAND
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Recognition of field roads based on improved U-Net++Network
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作者 lili Yang yuanbo li +4 位作者 Mengshuai Chang Yuanyuan Xu Bingbing Hu Xinxin Wang Caicong Wu 《International Journal of Agricultural and Biological Engineering》 SCIE 2023年第2期171-178,共8页
Unmanned driving of agricultural machinery has garnered significant attention in recent years,especially with the development of precision farming and sensor technologies.To achieve high performance and low cost,perce... Unmanned driving of agricultural machinery has garnered significant attention in recent years,especially with the development of precision farming and sensor technologies.To achieve high performance and low cost,perception tasks are of great importance.In this study,a low-cost and high-safety method was proposed for field road recognition in unmanned agricultural machinery.The approach of this study utilized point clouds,with low-resolution Lidar point clouds as inputs,generating high-resolution point clouds and Bird's Eye View(BEV)images that were encoded with several basic statistics.Using a BEV representation,road detection was reduced to a single-scale problem that could be addressed with an improved U-Net++neural network.Three enhancements were proposed for U-Net++:1)replacing the convolutional kernel in the original U-Net++ with an Asymmetric Convolution Block(ACBlock);2)adding a multi-branch Asymmetric Dilated Convolutional Block(MADC)in the highest semantic information layer;3)adding an Attention Gate(AG)model to the long-skip-connection in the decoding stage.The results of experiments of this study showed that our algorithm achieved a Mean Intersection Over Union of 96.54% on the 16-channel point clouds,which was 7.35 percentage points higher than U-Net++.Furthermore,the average processing time of the model was about 70 ms,meeting the time requirements of unmanned driving in agricultural machinery.The proposed method of this study can be applied to enhance the perception ability of unmanned agricultural machinery thereby increasing the safety of field road driving. 展开更多
关键词 image segmentation unmanned agricultural machinery field roads point cloud super-resolution point cloud bird’s eye view
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Biochar amendment changed soil-bound fractions of silver nanoparticles and ions but not their uptake by radish at an environmentally-relevant concentration
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作者 Jianzhou He yuanbo li +2 位作者 Haonan Qi Hui li Wei Zhang 《Biochar》 2020年第3期307-317,共11页
Plant uptake of silver nanoparticles(Ag NPs)and ions(Ag^(+))largely depends on their exchangeable and soil-bound fractions in soils,which may be influenced by biochar amendment.This study investigated the effects of b... Plant uptake of silver nanoparticles(Ag NPs)and ions(Ag^(+))largely depends on their exchangeable and soil-bound fractions in soils,which may be influenced by biochar amendment.This study investigated the effects of biochar amendment(0.1%and 1.0%)on soil sorption of Ag NPs and Ag^(+),their soil-bound fractions,and their uptake and translocation by radish grown in a loamy sand soil spiked with 1 mg/kg Ag NPs or Ag^(+).Sorption of Ag^(+)to the soils was much greater than that of Ag NPs,mainly because negatively charged soil particles would attract Ag^(+),but repel negatively charged Ag NPs.Biochar amend-ment at 1.0%(by weight)significantly decreased the reducible fraction of Ag^(+)in the soils with and without radish plants and increased the oxidisable fraction of Ag NPs in the soils with radish plants.Biochar amendment had no significant effect on Ag uptake by radish plants(p>0.05),probably due to low exchangeable Ag fractions in all experimental treatments.In this short-term experiment(35 days),the addition of 1 mg/kg Ag NPs or Ag^(+)did not substantially elevate the level of Ag in radish roots(0.05±0.02-1.06±0.98 mg/kg)and shoots(0.01±0.00-0.03±0.01 mg/kg),compared to the blank control(p>0.05).Radish uptake of Ag NPs and Ag^(+)at the environmentally-relevant concentration was low with root concentration factors between 0.03±0.03 to 0.29±0.21 and root-to-shoot translocation factors between 0.08±0.10 to 0.89±1.21,which may partially explain the non-significant effect of biochar amendment on Ag uptake. 展开更多
关键词 Silver nanoparticles BIOCHAR FRACTIONATION UPTAKE RADISH
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