The synthesis of bo rylated orga nofluorines is of great interest due to their potential values as synthons in modular construction of fluorine-containing molecules.Reported herein is a rhodium-catalyzed hydrobo ratio...The synthesis of bo rylated orga nofluorines is of great interest due to their potential values as synthons in modular construction of fluorine-containing molecules.Reported herein is a rhodium-catalyzed hydrobo ration of arylgem-difluoroalkenes leading to a series of α-difluoromethylated benzylborons.The use of cationic rhodium catalyst and a biphosphine ligand with large bite angle was crucial for reactivity by offering good regioselectivity and diminishing the undesired β-F elimination.Preliminary derivatizations of the products were conducted to showcase the utility of this protocol.展开更多
基金financial support from the National Natural Science Foundation of China(No.21971261)Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery(No.2019B030301005)+1 种基金Key Project of Chinese National Programs for Fundamental Research and Development(No.2016YFA0602900)the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(No.2017BT01Y093)is gratefully acknowledged。
文摘The synthesis of bo rylated orga nofluorines is of great interest due to their potential values as synthons in modular construction of fluorine-containing molecules.Reported herein is a rhodium-catalyzed hydrobo ration of arylgem-difluoroalkenes leading to a series of α-difluoromethylated benzylborons.The use of cationic rhodium catalyst and a biphosphine ligand with large bite angle was crucial for reactivity by offering good regioselectivity and diminishing the undesired β-F elimination.Preliminary derivatizations of the products were conducted to showcase the utility of this protocol.
