Splicing of pre-RNA is a key step in regulating eukaryotic gene expression.Most human genes undergo alternative splicing(AS),where the splice sites in a single gene can be selectively paired to produce multiple isofor...Splicing of pre-RNA is a key step in regulating eukaryotic gene expression.Most human genes undergo alternative splicing(AS),where the splice sites in a single gene can be selectively paired to produce multiple isoforms,greatly expanding the functional diversity(Pan et al.,2008;Wang et al.,2008).The regulation of AS plays a critical role in many cellular activities,such as cell differentiation.Therefore,the dysregulation of AS can lead to a variety of diseases,including cancers(Scotti and Swanson,2016).展开更多
基金supported by the National Key Research and Development Program of China(2021YFF0703702 to G.Z.2021YFA1300503 and 2018YFA0107602 to Z.W.)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB38040100 to Z.W.and XDB38030100 to G.Z.)the Starry Night Science Fund at Shanghai Institute for Advanced Study of Zhejiang University(SN-ZJU-SIAS-009 to Z.W.)。
文摘Splicing of pre-RNA is a key step in regulating eukaryotic gene expression.Most human genes undergo alternative splicing(AS),where the splice sites in a single gene can be selectively paired to produce multiple isoforms,greatly expanding the functional diversity(Pan et al.,2008;Wang et al.,2008).The regulation of AS plays a critical role in many cellular activities,such as cell differentiation.Therefore,the dysregulation of AS can lead to a variety of diseases,including cancers(Scotti and Swanson,2016).
