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个体化动态治疗方案和多重方案随机序贯试验在精神卫生研究中的应用(英文) 被引量:5
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作者 Ying LIU Donglin ZENG yuanjia wang 《上海精神医学》 2014年第6期376-383,共8页
动态治疗方案(Dynamic treatment regimens,DTRs)是一种序贯决策规则,是根据每个患者随时间变化而变化的特征和先前观察到的中间结果而量身定制的临床决策。精神障碍具有慢性和复杂性的特点,精神障碍患者具有异质性特点。这就要求随时... 动态治疗方案(Dynamic treatment regimens,DTRs)是一种序贯决策规则,是根据每个患者随时间变化而变化的特征和先前观察到的中间结果而量身定制的临床决策。精神障碍具有慢性和复杂性的特点,精神障碍患者具有异质性特点。这就要求随时间推移,根据个体对治疗反应的不同而分析出最佳的治疗方案,并动态地应用到患者之后的治疗中。多重方案随机序贯试验(Sequential Multiple Assignment Randomized Trial,SMARTs)的设计可以估计DTRs的治疗效应。SMARTs收集到大量的个体化变量和中间结果,在此基础上应用已有的现代统计工具可以优化DTRs。这些统计方法也可为今后的SMARTs研究设计推荐量身定制的变量。本文通过两个精神卫生研究案例介绍了DTRs和SMARTs,讨论了从SMARTs数据估算出最佳DTR的两种不同的计算机自动分析方法,并使用模拟数据演示这两种统计方法的性能。 展开更多
关键词 多重方案随机序贯试验 动态治疗方案 个体化医疗 O型学习 Q型学习 双稳健估计
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Biostatistics in Psychiatry (3)Effect size for dichotomous outcome measures
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作者 yuanjia wang Naihua DUAN 《上海精神医学》 2011年第3期184-186,共3页
关键词 《上海精神医学》 期刊 摘要 编辑部
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Heterogeneity of treatment effects
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作者 Naihua DUAN yuanjia wang 《上海精神医学》 2012年第1期50-51,共2页
关键词 治疗效果 异质性 药物治疗 抑郁症 临床 预计 患者
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A low-power Bluetooth-based wireless sensor network and its global confliction-solving impact localization method
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作者 yuanjia wang Lei QIU +1 位作者 Qiyun XU Liming SHI 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2024年第1期153-161,共9页
During the whole service lifetime of aircraft structures with composite materials,impacts are inevitable and can usually cause severe but barely visible damages.Since the occurrences of impact are random and unpredict... During the whole service lifetime of aircraft structures with composite materials,impacts are inevitable and can usually cause severe but barely visible damages.Since the occurrences of impact are random and unpredictable,it is a hotspot direction to develop an online impact monitoring system that can meet strict limitations of aerospace applications including small size,light weight,and low power consumption.Piezoelectric(PZT)sensor,being able to generate impact response signals with no external power and cover a large-scale structure with only a small amount of them,is a promising choice.Meanwhile,for real systems,networks with multiple nodes are normally required to monitor large-scale structures in a global way to identify any impact localization confliction,yet the existing studies are mostly evaluated with single nodes instead of networks.Therefore,in this paper,based on a new low-power node designed,a Bluetooth-based digital impact monitoring PZT sensor network is proposed for the first time with its global confliction-solving impact localization method.Evaluations of the system as a network are researched and analyzed on a complex real aircraft wing box for a global confliction-solving impact localization,showing a satisfying high accuracy. 展开更多
关键词 Bluetooth-based low-power design Confliction-solving evaluation Complex composites Piezoelectric sensors Wireless impact monitoring network
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Multicategory Classification Via Forward-Backward Support Vector Machine
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作者 Xuan Zhou yuanjia wang Donglin Zeng 《Communications in Mathematics and Statistics》 SCIE 2020年第3期319-339,共21页
In this paper,we propose a new algorithm to extend support vector machine(SVM)for binary classification to multicategory classification.The proposed method is based on a sequential binary classification algorithm.We f... In this paper,we propose a new algorithm to extend support vector machine(SVM)for binary classification to multicategory classification.The proposed method is based on a sequential binary classification algorithm.We first classify a target class by excluding the possibility of labeling as any other classes using a forward step of sequential SVM;we then exclude the already classified classes and repeat the same procedure for the remaining classes in a backward step.The proposed algorithm relies on SVM for each binary classification and utilizes only feasible data in each step;therefore,the method guarantees convergence and entails light computational burden.We prove Fisher consistency of the proposed forward–backward SVM(FB-SVM)and obtain a stochastic bound for the predicted misclassification rate.We conduct extensive simulations and analyze real-world data to demonstrate the superior performance of FB-SVM,for example,FB-SVM achieves a classification accuracy much higher than the current standard for predicting conversion from mild cognitive impairment to Alzheimer’s disease. 展开更多
关键词 Multicategory classification Fisher consistency Classification rate Risk bound Alzheimer’s disease
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