Multispectral imaging (MSI) technique is often used to capture imagesof the fundus by illuminating it with different wavelengths of light. However,these images are taken at different points in time such that eyeball m...Multispectral imaging (MSI) technique is often used to capture imagesof the fundus by illuminating it with different wavelengths of light. However,these images are taken at different points in time such that eyeball movementscan cause misalignment between consecutive images. The multispectral imagesequence reveals important information in the form of retinal and choroidal bloodvessel maps, which can help ophthalmologists to analyze the morphology of theseblood vessels in detail. This in turn can lead to a high diagnostic accuracy of several diseases. In this paper, we propose a novel semi-supervised end-to-end deeplearning framework called “Adversarial Segmentation and Registration Nets”(ASRNet) for the simultaneous estimation of the blood vessel segmentation andthe registration of multispectral images via an adversarial learning process. ASRNet consists of two subnetworks: (i) A segmentation module S that fulfills theblood vessel segmentation task, and (ii) A registration module R that estimatesthe spatial correspondence of an image pair. Based on the segmention-drivenregistration network, we train the segmentation network using a semi-supervisedadversarial learning strategy. Our experimental results show that the proposedASRNet can achieve state-of-the-art accuracy in segmentation and registrationtasks performed with real MSI datasets.展开更多
Optical Coherence Tomography(OCT)is very important in medicine and provide useful diagnostic information.Measuring retinal layer thicknesses plays a vital role in pathophysiologic factors of many ocular conditions.Amo...Optical Coherence Tomography(OCT)is very important in medicine and provide useful diagnostic information.Measuring retinal layer thicknesses plays a vital role in pathophysiologic factors of many ocular conditions.Among the existing retinal layer segmentation approaches,learning or deep learning-based methods belong to the state-of-art.However,most of these techniques rely on manual-marked layers and the performances are limited due to the image quality.In order to overcome this limitation,we build a framework based on gray value curve matching,which uses depth learning to match the curve for semi-automatic segmentation of retinal layers from OCT.The depth convolution network learns the column correspondence in the OCT image unsupervised.The whole OCT image participates in the depth convolution neural network operation,compares the gray value of each column,and matches the gray value sequence of the transformation column and the next column.Using this algorithm,when a boundary point is manually specified,we can accurately segment the boundary between retinal layers.Our experimental results obtained from a 54-subjects database of both normal healthy eyes and affected eyes demonstrate the superior performances of our approach.展开更多
Because of the unstructured characteristics of natural orchards,the efficient detection and segmentation applications of green fruits remain an essential challenge for intelligent agriculture.Therefore,an innovative f...Because of the unstructured characteristics of natural orchards,the efficient detection and segmentation applications of green fruits remain an essential challenge for intelligent agriculture.Therefore,an innovative fruit segmentation method based on deep learning,termed SE-COTR(segmentation based on coordinate transformer),is proposed to achieve accurate and real-time segmentation of green apples.The lightweight network MobileNetV2 is used as the backbone,combined with the constructed coordinate attention-based coordinate transformer module to enhance the focus on effective features.In addition,joint pyramid upsampling module is optimized for integrating multiscale features,making the model suitable for the detection and segmentation of target fruits with different sizes.Finally,in combination with the outputs of the function heads,the dynamic convolution operation is applied to predict the instance mask.In complex orchard environment with variable conditions,SE-COTR achieves a mean average precision of 61.6%with low complexity for green apple fruit segmentation at severe occlusion and different fruit scales.Especially,the segmentation accuracy for small target fruits reaches 43.3%,which is obviously better than other advanced segmentation models and realizes good recognition results.The proposed method effectively solves the problem of low accuracy and overly complex fruit segmentation models with the same color as the background and can be built in portable mobile devices to undertake accurate and efficient agricultural works in complex orchard.展开更多
Hippocampal morphological change is one of the main hallmarks of Alzheimer’s disease(AD).However,whether hippocampal radiomic features are robust as predictors of progression from mild cognitive impairment(MCI)to AD ...Hippocampal morphological change is one of the main hallmarks of Alzheimer’s disease(AD).However,whether hippocampal radiomic features are robust as predictors of progression from mild cognitive impairment(MCI)to AD dementia and whether these features provide any neurobiological foundation remains unclear.The primary aim of this study was to verify whether hippocampal radiomic features can serve as robust magnetic resonance imaging(MRI)markers for AD.Multivariate classifier-based support vector machine(SVM)analysis provided individual-level predictions for distinguishing AD patients(n=261)from normal controls(NCs;n=231)with an accuracy of 88.21%and intersite crossvalidation.Further analyses of a large,independent the Alzheimer’s Disease Neuroimaging Initiative(ADNI)dataset(n=1228)reinforced these findings.In MCI groups,a systemic analysis demonstrated that the identified features were significantly associated with clinical features(e.g.,apolipoprotein E(APOE)genotype,polygenic risk scores,cerebrospinal fluid(CSF)Ab,CSF Tau),and longitudinal changes in cognition ability;more importantly,the radiomic features had a consistently altered pattern with changes in the MMSE scores over 5 years of follow-up.These comprehensive results suggest that hippocampal radiomic features can serve as robust biomarkers for clinical application in AD/MCI,and further provide evidence for predicting whether an MCI subject would convert to AD based on the radiomics of the hippocampus.The results of this study are expected to have a substantial impact on the early diagnosis of AD/MCI.展开更多
Due to the low working efficiency of apple harvesting robots,there is still a long way to go for commercialization.The machine performance and extended operating time are the two research aspects for improving efficie...Due to the low working efficiency of apple harvesting robots,there is still a long way to go for commercialization.The machine performance and extended operating time are the two research aspects for improving efficiencies of harvesting robots,this study focused on the extended operating time and proposed a round-the-clock operation mode.Due to the influences of light,temperature,humidity,etc.,the working environment at night is relatively complex,and thus restricts the operating efficiency of the apple harvesting robot.Three different artificial light sources(incandescent lamp,fluorescent lamp,and LED lights)were selected for auxiliary light according to certain rules so that the apple night vision images could be captured.In addition,by color analysis,night and natural light images were compared to find out the color characteristics of the night vision images,and intuitive visual and difference image methods were used to analyze the noise characteristics.The results showed that the incandescent lamp is the best artificial auxiliary light for apple harvesting robots working at night,and the type of noise contained in apple night vision images is Gaussian noise mixed with some salt and pepper noise.The preprocessing method can provide a theoretical and technical reference for subsequent image processing.展开更多
Despite of significant achievements made in the detection of target fruits,small fruit detection remains a great challenge,especially for immature small green fruits with a few pixels.The closeness of color between th...Despite of significant achievements made in the detection of target fruits,small fruit detection remains a great challenge,especially for immature small green fruits with a few pixels.The closeness of color between the fruit skin and the background greatly increases the difficulty of locating small target fruits in the natural orchard environment.In this paper,we propose a balanced feature pyramid network(BFP Net)for small apple detection.展开更多
Because of the unstructured characteristics of natural orchards,the efficient detection and segmentation applications of green fruits remain an essential challenge for intelligent agriculture.Therefore,an innovative f...Because of the unstructured characteristics of natural orchards,the efficient detection and segmentation applications of green fruits remain an essential challenge for intelligent agriculture.Therefore,an innovative fruit segmentation method based on deep learning,termed SE-COTR(segmentation based on coordinate transformer),is proposed to achieve accurate and real-time segmentation of green apples.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.81871508 and 61773246)the Major Program of Shandong Province Natural Science Foundation(Grant No.ZR2019ZD04 and ZR2018ZB0419)the Taishan Scholar Program of Shandong Province of China(Grant No.TSHW201502038).
文摘Multispectral imaging (MSI) technique is often used to capture imagesof the fundus by illuminating it with different wavelengths of light. However,these images are taken at different points in time such that eyeball movementscan cause misalignment between consecutive images. The multispectral imagesequence reveals important information in the form of retinal and choroidal bloodvessel maps, which can help ophthalmologists to analyze the morphology of theseblood vessels in detail. This in turn can lead to a high diagnostic accuracy of several diseases. In this paper, we propose a novel semi-supervised end-to-end deeplearning framework called “Adversarial Segmentation and Registration Nets”(ASRNet) for the simultaneous estimation of the blood vessel segmentation andthe registration of multispectral images via an adversarial learning process. ASRNet consists of two subnetworks: (i) A segmentation module S that fulfills theblood vessel segmentation task, and (ii) A registration module R that estimatesthe spatial correspondence of an image pair. Based on the segmention-drivenregistration network, we train the segmentation network using a semi-supervisedadversarial learning strategy. Our experimental results show that the proposedASRNet can achieve state-of-the-art accuracy in segmentation and registrationtasks performed with real MSI datasets.
基金This work was supported in part by the National Nature Science Foundation of China under Grant 61572300,Grant 81871508,and Grant61773246in part by the Taishan Scholar Program of Shandong Province of China under Grant TSHW201502038+2 种基金in part by the Major Program of Shandong Province Natural Science Foundation under Grant ZR2018ZB0419in part by the Primary Research and Development Plan of Shandong Province under Grant 2017GGX10112,2019GNC106115Shandong Province Higher Educational Science and Technology Program(No.J18KA308).
文摘Optical Coherence Tomography(OCT)is very important in medicine and provide useful diagnostic information.Measuring retinal layer thicknesses plays a vital role in pathophysiologic factors of many ocular conditions.Among the existing retinal layer segmentation approaches,learning or deep learning-based methods belong to the state-of-art.However,most of these techniques rely on manual-marked layers and the performances are limited due to the image quality.In order to overcome this limitation,we build a framework based on gray value curve matching,which uses depth learning to match the curve for semi-automatic segmentation of retinal layers from OCT.The depth convolution network learns the column correspondence in the OCT image unsupervised.The whole OCT image participates in the depth convolution neural network operation,compares the gray value of each column,and matches the gray value sequence of the transformation column and the next column.Using this algorithm,when a boundary point is manually specified,we can accurately segment the boundary between retinal layers.Our experimental results obtained from a 54-subjects database of both normal healthy eyes and affected eyes demonstrate the superior performances of our approach.
基金supported by Natural Science Foundation of Shandong Province in China(nos.ZR2020MF076 and ZR2019BA018)National Nature Science Foundation of China(nos.21978139,62072289,and 61903288)Taishan Scholar Program of Shandong Province of China,and New Twentieth Items of Universities in Jinan(2021GXRC049).
文摘Because of the unstructured characteristics of natural orchards,the efficient detection and segmentation applications of green fruits remain an essential challenge for intelligent agriculture.Therefore,an innovative fruit segmentation method based on deep learning,termed SE-COTR(segmentation based on coordinate transformer),is proposed to achieve accurate and real-time segmentation of green apples.The lightweight network MobileNetV2 is used as the backbone,combined with the constructed coordinate attention-based coordinate transformer module to enhance the focus on effective features.In addition,joint pyramid upsampling module is optimized for integrating multiscale features,making the model suitable for the detection and segmentation of target fruits with different sizes.Finally,in combination with the outputs of the function heads,the dynamic convolution operation is applied to predict the instance mask.In complex orchard environment with variable conditions,SE-COTR achieves a mean average precision of 61.6%with low complexity for green apple fruit segmentation at severe occlusion and different fruit scales.Especially,the segmentation accuracy for small target fruits reaches 43.3%,which is obviously better than other advanced segmentation models and realizes good recognition results.The proposed method effectively solves the problem of low accuracy and overly complex fruit segmentation models with the same color as the background and can be built in portable mobile devices to undertake accurate and efficient agricultural works in complex orchard.
基金partially supported by the National Key Research and Development Program of China (2016YFC1305904)the National Natural Science Foundation of China (81871438, 81901101, 61633018, 81571062, 81400890, 81871398)+10 种基金the Strategic Priority Research Program (B) of the Chinese Academy of Sciences (XDB32020200)the Beijing Municipal Science & Technology Commission (Z171100000117001, Z171100000117002)the Primary Research & Development Plan of Shandong Province (2017GGX10112)the Open Project Program of the National Laboratory of Pattern Recognition (NLPR) (201900021)Data collection and sharing for this project was funded by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904)DOD ADNI (Department of Defense award number W81XWH-12-2-0012)funded by the National Institute on Agingthe National Institute of Biomedical Imaging and Bioengineeringgenerous contributions from Abb Vie, Alzheimer’s AssociationAlzheimer’s Drug Discovery FoundationThe Canadian Institutes of Health Research provide funds to support ADNI clinical sites in Canada。
文摘Hippocampal morphological change is one of the main hallmarks of Alzheimer’s disease(AD).However,whether hippocampal radiomic features are robust as predictors of progression from mild cognitive impairment(MCI)to AD dementia and whether these features provide any neurobiological foundation remains unclear.The primary aim of this study was to verify whether hippocampal radiomic features can serve as robust magnetic resonance imaging(MRI)markers for AD.Multivariate classifier-based support vector machine(SVM)analysis provided individual-level predictions for distinguishing AD patients(n=261)from normal controls(NCs;n=231)with an accuracy of 88.21%and intersite crossvalidation.Further analyses of a large,independent the Alzheimer’s Disease Neuroimaging Initiative(ADNI)dataset(n=1228)reinforced these findings.In MCI groups,a systemic analysis demonstrated that the identified features were significantly associated with clinical features(e.g.,apolipoprotein E(APOE)genotype,polygenic risk scores,cerebrospinal fluid(CSF)Ab,CSF Tau),and longitudinal changes in cognition ability;more importantly,the radiomic features had a consistently altered pattern with changes in the MMSE scores over 5 years of follow-up.These comprehensive results suggest that hippocampal radiomic features can serve as robust biomarkers for clinical application in AD/MCI,and further provide evidence for predicting whether an MCI subject would convert to AD based on the radiomics of the hippocampus.The results of this study are expected to have a substantial impact on the early diagnosis of AD/MCI.
基金supported by the Natural Science Foundation of Shandong Province in China(ZR2017BC013,ZR2014FM001)National Nature Science Foundation of China(No.31571571,61572300)+1 种基金Taishan Scholar Program of Shandong Province of China(No.TSHW201502038)Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘Due to the low working efficiency of apple harvesting robots,there is still a long way to go for commercialization.The machine performance and extended operating time are the two research aspects for improving efficiencies of harvesting robots,this study focused on the extended operating time and proposed a round-the-clock operation mode.Due to the influences of light,temperature,humidity,etc.,the working environment at night is relatively complex,and thus restricts the operating efficiency of the apple harvesting robot.Three different artificial light sources(incandescent lamp,fluorescent lamp,and LED lights)were selected for auxiliary light according to certain rules so that the apple night vision images could be captured.In addition,by color analysis,night and natural light images were compared to find out the color characteristics of the night vision images,and intuitive visual and difference image methods were used to analyze the noise characteristics.The results showed that the incandescent lamp is the best artificial auxiliary light for apple harvesting robots working at night,and the type of noise contained in apple night vision images is Gaussian noise mixed with some salt and pepper noise.The preprocessing method can provide a theoretical and technical reference for subsequent image processing.
基金This work is supported by the Natural Science Foundation of Shandong Province in China(No.:ZR2020MF076)the National Nature Science Foundation of China(No.:62072289)+2 种基金the Focus on Research and Development Plan in Shandong Province(No.:2019GNC106115)the Taishan Scholar Program of Shandong Province of Chinathe New Twentieth Items of Universities in Jinan(2021GXRC049).
文摘Despite of significant achievements made in the detection of target fruits,small fruit detection remains a great challenge,especially for immature small green fruits with a few pixels.The closeness of color between the fruit skin and the background greatly increases the difficulty of locating small target fruits in the natural orchard environment.In this paper,we propose a balanced feature pyramid network(BFP Net)for small apple detection.
基金This work is supported by Natural Science Foundation of Shandong Province in China(nos.ZR2020MF076 and ZR2019BA018)National Nature Science Foundation of China(nos.21978139,62072289,and 61903288)Taishan Scholar Program of Shandong Province of China,and New Twentieth Items of Universities in Jinan(2021GXRC049).
文摘Because of the unstructured characteristics of natural orchards,the efficient detection and segmentation applications of green fruits remain an essential challenge for intelligent agriculture.Therefore,an innovative fruit segmentation method based on deep learning,termed SE-COTR(segmentation based on coordinate transformer),is proposed to achieve accurate and real-time segmentation of green apples.