Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has posed a serious challenge to emergency departments that usually encounter emergencies and severe diseases.[1-5]Angiotensin-converting enzyme 2(ACE2),a pro...Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has posed a serious challenge to emergency departments that usually encounter emergencies and severe diseases.[1-5]Angiotensin-converting enzyme 2(ACE2),a protein that interacts with the viral spike protein(s),allows SARS-CoV-2 to penetrate epithelial cells.[6]There is mounting evidence that suggests that the digestive system may also be affected.[7]An observational study described potential patterns of pancreatic injury(elevated amylase and lipase)in patients with coronavirus disease 2019(COVID-19).[8]Additionally,sporadic case reports have described secondary pancreatitis in patients with SARS-CoV-2 infection and presented imaging evidence.[9]Moreover,a previous study showed that COVID-19 patients not only have a higher risk of developing acute pancreatitis(AP),but also have a significantly higher mortality than those without COVID-19.[10]Using bioinformatics analysis,it may be possible to reveal how COVID-19 and AP are related.In this study,two RNA-seq datasets of SARS-CoV-2 and AP were selected for analysis.展开更多
In recent years,the development of Chinese scientific journals does not match the scientific development in China,especially in the field of minimally invasive surgery medicine.Scientific journals of minimally invasiv...In recent years,the development of Chinese scientific journals does not match the scientific development in China,especially in the field of minimally invasive surgery medicine.Scientific journals of minimally invasive medicine in China face competition not only from other traditional journals at home and abroad,but also from new media.Journals of minimally invasive medicine should be more creative,find innovative business solutions,attract professional manuscripts,and even incentivize people to contribute to projects.By doing so,we can constantly improve journals'influence,transmission,guidance and credibility in step with the pace of rapid advances in technology.展开更多
To the Editor:Sarcopenia is defined as age-related loss of skeletal musclemass and strength,with an incidence of5%to 13%in persons aged>60 years.[1]Sarcopenia is considered a major contributor of frailty in the eld...To the Editor:Sarcopenia is defined as age-related loss of skeletal musclemass and strength,with an incidence of5%to 13%in persons aged>60 years.[1]Sarcopenia is considered a major contributor of frailty in the elderly,and frailty is reported to be associated withpoor outcomes of older people.Sarcopenia can also increase the risk of falls and fractures.展开更多
Epstein-Barr virus(EBV),a double-stranded DNA virus with an envelope,is a ubiquitous pathogen that is prevalent in humans,although most people who contract it do not develop symptoms(Kerr,2019).While the primary cells...Epstein-Barr virus(EBV),a double-stranded DNA virus with an envelope,is a ubiquitous pathogen that is prevalent in humans,although most people who contract it do not develop symptoms(Kerr,2019).While the primary cells EBV attacks are epithelial cells and B lymphocytes,its target range expands to a variety of cell types in immunodeficient hosts.Serological change occurs in 90%of infected patients.Therefore,immunoglobulin M(IgM)and IgG,serologically reactive to viral capsid antigens,are reliable biomarkers for the detection of acute and chronic EBV infections(Cohen,2000).Symptoms of EBV infection vary according to age and immune status.展开更多
Chest pain is one of the most common complaints in the emergency department.Diseases of the heart,aorta,lungs,esophagus,stomach,mediastinum,pleura,and abdominal viscera can all cause chest discomfort(Gulati et al.,202...Chest pain is one of the most common complaints in the emergency department.Diseases of the heart,aorta,lungs,esophagus,stomach,mediastinum,pleura,and abdominal viscera can all cause chest discomfort(Gulati et al.,2021;Jiao et al.,2021;Lu et al.,2022).展开更多
Poisoning is often characterized by the acute onset,rapid progress,or specific manifestations of pathological symptoms,such as pulmonary fibrosis due to paraquat poisoning or high mortality arising from dinitrophenol ...Poisoning is often characterized by the acute onset,rapid progress,or specific manifestations of pathological symptoms,such as pulmonary fibrosis due to paraquat poisoning or high mortality arising from dinitrophenol intoxication (Jiang et al.,2016;Wang et al.,2017;Feng et al.,2018;Lu,2018;Xu and Lu,2019).Unlike general poisoning,however,the manifestation of n-hexane intoxication is subacute,and its clinical symptoms are dormant,and thus the provision of a timely and correct diagnosis is often difficult.展开更多
Due to the low specificity and sensitivity of biomarkers in sepsis diagnostics,the prognosis of sepsis patient outcomes still relies on the assessment of clinical symptoms.Inflammatory response is crucial to sepsis on...Due to the low specificity and sensitivity of biomarkers in sepsis diagnostics,the prognosis of sepsis patient outcomes still relies on the assessment of clinical symptoms.Inflammatory response is crucial to sepsis onset and progression;however,the significance of inflammatory response-related genes(IRRGs)in sepsis prognosis is uncertain.This study developed an IRRG-based signature for sepsis prognosis and immunological function.The Gene Expression Omnibus(GEO)database was retrieved for two sepsis microarray datasets,GSE64457 and GSE69528,followed by gene set enrichment analysis(GSEA)comparing sepsis and healthy samples.A predictive signature for IRRGs was created using least absolute shrinkage and selection operator(LASSO).To confirm the efficacy and reliability of the new prognostic signature,Cox regression,Kaplan-Meier(K-M)survival,and receiver operating characteristic(ROC)curve analyses were performed.Subsequently,we employed the GSE95233 dataset to independently validate the prognostic signature.A single-sample GSEA(ssGSEA)was conducted to quantify the immune cell enrichment score and immune-related pathway activity.We found that more gene sets were enriched in the inflammatory response in sepsis patient samples than in healthy patient samples,as determined by GSEA.The signature of nine IRRGs permitted the patients to be classified into two risk categories.Patients in the low-risk group showed significantly better 28-d survival than those in the high-risk group.ROC curve analysis corroborated the predictive capacity of the signature,with the area under the curve(AUC)for 28-d survival reaching 0.866.Meanwhile,the ss GSEA showed that the two risk groups had different immune states.The validation set and external dataset showed that the signature was clinically predictive.In conclusion,a signature consisting of nine IRRGs can be utilized to predict prognosis and influence the immunological status of sepsis patients.Thus,intervention based on these IRRGs may become a therapeutic option in the future.展开更多
The superior mesenteric artery(SMA)is one of the visceral branches of the abdominal aorta.It has multiple branches to supply blood and nutrition to the intestinal segment,and these form an anastomosis with each other....The superior mesenteric artery(SMA)is one of the visceral branches of the abdominal aorta.It has multiple branches to supply blood and nutrition to the intestinal segment,and these form an anastomosis with each other.SMA injuries are usually classified as major visceral artery injuries,and have an incidence of<1%.The clinical manifestations of patients with SMA injuries include intra-abdominal bleeding and peritoneal irritation.The compromised blood supply can lead to intestinal ischemia and perforation.These injuries are often not diagnosed in time and have significant mortality rates of 25%-68%due to the lack of specific features(Maithel et al.,2020).Not only that,but patients with less severe trauma or no visible damage on initial examination may still have clinically significant intra-abdominal injuries(Nishijima et al.,2012).Emergency departments often encounter multiple cases that require urgent diagnosis and treatment(Li et al.,2021;Zhang et al.,2021;Zhou et al.,2021),and therefore,it is imperative to diagnose and manage these rare injuries expeditiously.展开更多
Glufosinate-ammonium herbicides are the most widely used broad-spectrum,non-selective herbicides in the world.Glufosinate-ammonium is a structural analogue of glutamate(Glu)which can irreversibly inhibit the activity ...Glufosinate-ammonium herbicides are the most widely used broad-spectrum,non-selective herbicides in the world.Glufosinate-ammonium is a structural analogue of glutamate(Glu)which can irreversibly inhibit the activity of glutamine synthetase(GS)and Glu decarboxylase in plants,thereby blocking the synthesis of glutamine(Gln)from Glu and ammonia(Hoerlein,1994).This causes the plants to die because of the nitrogen metabolism disorder and subsequent intracellular accumulation of ammonia.In humans,the characteristic features of glufosinate-ammonium herbicide poisoning include gastrointestinal symptoms and neurotoxicity(Watanabe and Sano,1998).展开更多
基金sponsored by the Key Research and Development Program of Zhejiang Province (2019C03076)The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript。
文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has posed a serious challenge to emergency departments that usually encounter emergencies and severe diseases.[1-5]Angiotensin-converting enzyme 2(ACE2),a protein that interacts with the viral spike protein(s),allows SARS-CoV-2 to penetrate epithelial cells.[6]There is mounting evidence that suggests that the digestive system may also be affected.[7]An observational study described potential patterns of pancreatic injury(elevated amylase and lipase)in patients with coronavirus disease 2019(COVID-19).[8]Additionally,sporadic case reports have described secondary pancreatitis in patients with SARS-CoV-2 infection and presented imaging evidence.[9]Moreover,a previous study showed that COVID-19 patients not only have a higher risk of developing acute pancreatitis(AP),but also have a significantly higher mortality than those without COVID-19.[10]Using bioinformatics analysis,it may be possible to reveal how COVID-19 and AP are related.In this study,two RNA-seq datasets of SARS-CoV-2 and AP were selected for analysis.
文摘In recent years,the development of Chinese scientific journals does not match the scientific development in China,especially in the field of minimally invasive surgery medicine.Scientific journals of minimally invasive medicine in China face competition not only from other traditional journals at home and abroad,but also from new media.Journals of minimally invasive medicine should be more creative,find innovative business solutions,attract professional manuscripts,and even incentivize people to contribute to projects.By doing so,we can constantly improve journals'influence,transmission,guidance and credibility in step with the pace of rapid advances in technology.
基金supported by the National Key Research and Development Program(No.2018YFC2000301)Key Research&Development Program of Zhejiang(No.2022C03161)
文摘To the Editor:Sarcopenia is defined as age-related loss of skeletal musclemass and strength,with an incidence of5%to 13%in persons aged>60 years.[1]Sarcopenia is considered a major contributor of frailty in the elderly,and frailty is reported to be associated withpoor outcomes of older people.Sarcopenia can also increase the risk of falls and fractures.
基金by the Ethics Committee of the First Affiliated Hospital,Zhejiang University School of Medicine(StudyID:20230163).
文摘Epstein-Barr virus(EBV),a double-stranded DNA virus with an envelope,is a ubiquitous pathogen that is prevalent in humans,although most people who contract it do not develop symptoms(Kerr,2019).While the primary cells EBV attacks are epithelial cells and B lymphocytes,its target range expands to a variety of cell types in immunodeficient hosts.Serological change occurs in 90%of infected patients.Therefore,immunoglobulin M(IgM)and IgG,serologically reactive to viral capsid antigens,are reliable biomarkers for the detection of acute and chronic EBV infections(Cohen,2000).Symptoms of EBV infection vary according to age and immune status.
基金supported by the Key Research and Development Program of Zhejiang Province(No.2019C03076),China。
文摘Chest pain is one of the most common complaints in the emergency department.Diseases of the heart,aorta,lungs,esophagus,stomach,mediastinum,pleura,and abdominal viscera can all cause chest discomfort(Gulati et al.,2021;Jiao et al.,2021;Lu et al.,2022).
基金supported by the Foundation of Key Discipline Construction of Zhejiang Province for Traditional Chinese Medicine(No.2017-XK-A36),China。
文摘Poisoning is often characterized by the acute onset,rapid progress,or specific manifestations of pathological symptoms,such as pulmonary fibrosis due to paraquat poisoning or high mortality arising from dinitrophenol intoxication (Jiang et al.,2016;Wang et al.,2017;Feng et al.,2018;Lu,2018;Xu and Lu,2019).Unlike general poisoning,however,the manifestation of n-hexane intoxication is subacute,and its clinical symptoms are dormant,and thus the provision of a timely and correct diagnosis is often difficult.
基金supported by theKey Research and Development Program of Zhejiang Province(No.2019C03076)the Opening Foundation of the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases(No.2018KF02),China.
文摘Due to the low specificity and sensitivity of biomarkers in sepsis diagnostics,the prognosis of sepsis patient outcomes still relies on the assessment of clinical symptoms.Inflammatory response is crucial to sepsis onset and progression;however,the significance of inflammatory response-related genes(IRRGs)in sepsis prognosis is uncertain.This study developed an IRRG-based signature for sepsis prognosis and immunological function.The Gene Expression Omnibus(GEO)database was retrieved for two sepsis microarray datasets,GSE64457 and GSE69528,followed by gene set enrichment analysis(GSEA)comparing sepsis and healthy samples.A predictive signature for IRRGs was created using least absolute shrinkage and selection operator(LASSO).To confirm the efficacy and reliability of the new prognostic signature,Cox regression,Kaplan-Meier(K-M)survival,and receiver operating characteristic(ROC)curve analyses were performed.Subsequently,we employed the GSE95233 dataset to independently validate the prognostic signature.A single-sample GSEA(ssGSEA)was conducted to quantify the immune cell enrichment score and immune-related pathway activity.We found that more gene sets were enriched in the inflammatory response in sepsis patient samples than in healthy patient samples,as determined by GSEA.The signature of nine IRRGs permitted the patients to be classified into two risk categories.Patients in the low-risk group showed significantly better 28-d survival than those in the high-risk group.ROC curve analysis corroborated the predictive capacity of the signature,with the area under the curve(AUC)for 28-d survival reaching 0.866.Meanwhile,the ss GSEA showed that the two risk groups had different immune states.The validation set and external dataset showed that the signature was clinically predictive.In conclusion,a signature consisting of nine IRRGs can be utilized to predict prognosis and influence the immunological status of sepsis patients.Thus,intervention based on these IRRGs may become a therapeutic option in the future.
基金supported by the Foundation of Key Discipline Construction of Zhejiang Province for Traditional Chinese Medicine(No.2017-XK-A36),China.
文摘The superior mesenteric artery(SMA)is one of the visceral branches of the abdominal aorta.It has multiple branches to supply blood and nutrition to the intestinal segment,and these form an anastomosis with each other.SMA injuries are usually classified as major visceral artery injuries,and have an incidence of<1%.The clinical manifestations of patients with SMA injuries include intra-abdominal bleeding and peritoneal irritation.The compromised blood supply can lead to intestinal ischemia and perforation.These injuries are often not diagnosed in time and have significant mortality rates of 25%-68%due to the lack of specific features(Maithel et al.,2020).Not only that,but patients with less severe trauma or no visible damage on initial examination may still have clinically significant intra-abdominal injuries(Nishijima et al.,2012).Emergency departments often encounter multiple cases that require urgent diagnosis and treatment(Li et al.,2021;Zhang et al.,2021;Zhou et al.,2021),and therefore,it is imperative to diagnose and manage these rare injuries expeditiously.
基金supported by the Key Research and Development Program of Zhejiang Province(No.2019C03076),China。
文摘Glufosinate-ammonium herbicides are the most widely used broad-spectrum,non-selective herbicides in the world.Glufosinate-ammonium is a structural analogue of glutamate(Glu)which can irreversibly inhibit the activity of glutamine synthetase(GS)and Glu decarboxylase in plants,thereby blocking the synthesis of glutamine(Gln)from Glu and ammonia(Hoerlein,1994).This causes the plants to die because of the nitrogen metabolism disorder and subsequent intracellular accumulation of ammonia.In humans,the characteristic features of glufosinate-ammonium herbicide poisoning include gastrointestinal symptoms and neurotoxicity(Watanabe and Sano,1998).
