Successful extracorporeal membrane oxygenation-assisted treatment for a kidney transplant recipient infected with severe COVID-19

Clinical practice has shown that kidney transplant recipients infected with COVID-19 are prone to developing critical illness and have a higher mortality rate.[1]Kidney transplant recipients require long-term oral anti-rejection drugs to suppress the immune response.This result may be related to the strong immunosuppression in kidney transplant recipients compared to the general population.[2]Therefore,the treatment of kidney transplant recipients infected with severe COVID-19 is a difficult problem.Here,we report the use of extracorporeal membrane oxygenation(ECMO)-assisted treatment for a kidney transplant recipient who was infected with severe COVID-19.

Uncovering the potential pathological mechanism of acute pancreatitis in patients with COVID-19 by bioinformatics methods

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has posed a serious challenge to emergency departments that usually encounter emergencies and severe diseases.[1-5]Angiotensin-converting enzyme 2(ACE2),a protein that interacts with the viral spike protein(s),allows SARS-CoV-2 to penetrate epithelial cells.[6]There is mounting evidence that suggests that the digestive system may also be affected.[7]An observational study described potential patterns of pancreatic injury(elevated amylase and lipase)in patients with coronavirus disease 2019(COVID-19).[8]Additionally,sporadic case reports have described secondary pancreatitis in patients with SARS-CoV-2 infection and presented imaging evidence.[9]Moreover,a previous study showed that COVID-19 patients not only have a higher risk of developing acute pancreatitis(AP),but also have a significantly higher mortality than those without COVID-19.[10]Using bioinformatics analysis,it may be possible to reveal how COVID-19 and AP are related.In this study,two RNA-seq datasets of SARS-CoV-2 and AP were selected for analysis.

Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning

Glufosinate-ammonium herbicides are the most widely used broad-spectrum,non-selective herbicides in the world.Glufosinate-ammonium is a structural analogue of glutamate(Glu)which can irreversibly inhibit the activity of glutamine synthetase(GS)and Glu decarboxylase in plants,thereby blocking the synthesis of glutamine(Gln)from Glu and ammonia(Hoerlein,1994).This causes the plants to die because of the nitrogen metabolism disorder and subsequent intracellular accumulation of ammonia.In humans,the characteristic features of glufosinate-ammonium herbicide poisoning include gastrointestinal symptoms and neurotoxicity(Watanabe and Sano,1998).

Promoting rapid development of Chinese minimally invasive medicine journals

In recent years,the development of Chinese scientific journals does not match the scientific development in China,especially in the field of minimally invasive surgery medicine.Scientific journals of minimally invasive medicine in China face competition not only from other traditional journals at home and abroad,but also from new media.Journals of minimally invasive medicine should be more creative,find innovative business solutions,attract professional manuscripts,and even incentivize people to contribute to projects.By doing so,we can constantly improve journals'influence,transmission,guidance and credibility in step with the pace of rapid advances in technology.

新型冠状病毒感染防控新阶段公立医院运营面临的难题及思考

新型冠状病毒感染疫情以来,中国根据病毒特点采取科学的疫情防控,经历了不同的疫情防控阶段.自疫情防控"新十条"出台后,新型冠状病毒感染人数激增,给公立医院的救治工作带来了巨大的挑战.在新型冠状病毒感染防控新阶段,公立医院在应对疫情冲击的过程中暴露出许多弊端,本文对此进行分析总结,并提出新形势下提升医院诊治和救助能力的建议:①提升基层医院救治水平,缓解中心医院诊治压力;②优化分级分类诊疗模式,提高医院运营效率;③构建急救及重症救治系统大平台,平衡人员和各类物资供给;④推进"防治结合"的医疗模式,保障人民群众安全健康.

Inflammatory granuloma of the trachea: a rare case with Epstin-Barr virus infection

Epstein-Barr virus(EBV),a double-stranded DNA virus with an envelope,is a ubiquitous pathogen that is prevalent in humans,although most people who contract it do not develop symptoms(Kerr,2019).While the primary cells EBV attacks are epithelial cells and B lymphocytes,its target range expands to a variety of cell types in immunodeficient hosts.Serological change occurs in 90%of infected patients.Therefore,immunoglobulin M(IgM)and IgG,serologically reactive to viral capsid antigens,are reliable biomarkers for the detection of acute and chronic EBV infections(Cohen,2000).Symptoms of EBV infection vary according to age and immune status.

Perforation of the esophagus:an overlooked cause of chest pain as a complication of esophageal foreign bodies

Chest pain is one of the most common complaints in the emergency department.Diseases of the heart,aorta,lungs,esophagus,stomach,mediastinum,pleura,and abdominal viscera can all cause chest discomfort(Gulati et al.,2021;Jiao et al.,2021;Lu et al.,2022).

Development and validation of a predictive nomogram for sarcopenia among older people in China

To the Editor:Sarcopenia is defined as age-related loss of skeletal musclemass and strength,with an incidence of5%to 13%in persons aged>60 years.[1]Sarcopenia is considered a major contributor of frailty in the elderly,and frailty is reported to be associated withpoor outcomes of older people.Sarcopenia can also increase the risk of falls and fractures.

Peripheral nerve injury in patients exposed to n-hexane:an analysis of eight cases

Poisoning is often characterized by the acute onset,rapid progress,or specific manifestations of pathological symptoms,such as pulmonary fibrosis due to paraquat poisoning or high mortality arising from dinitrophenol intoxication (Jiang et al.,2016;Wang et al.,2017;Feng et al.,2018;Lu,2018;Xu and Lu,2019).Unlike general poisoning,however,the manifestation of n-hexane intoxication is subacute,and its clinical symptoms are dormant,and thus the provision of a timely and correct diagnosis is often difficult.

Isolated superior mesenteric artery rupture caused by abdominal trauma

The superior mesenteric artery(SMA)is one of the visceral branches of the abdominal aorta.It has multiple branches to supply blood and nutrition to the intestinal segment,and these form an anastomosis with each other.SMA injuries are usually classified as major visceral artery injuries,and have an incidence of<1%.The clinical manifestations of patients with SMA injuries include intra-abdominal bleeding and peritoneal irritation.The compromised blood supply can lead to intestinal ischemia and perforation.These injuries are often not diagnosed in time and have significant mortality rates of 25%-68%due to the lack of specific features(Maithel et al.,2020).Not only that,but patients with less severe trauma or no visible damage on initial examination may still have clinically significant intra-abdominal injuries(Nishijima et al.,2012).Emergency departments often encounter multiple cases that require urgent diagnosis and treatment(Li et al.,2021;Zhang et al.,2021;Zhou et al.,2021),and therefore,it is imperative to diagnose and manage these rare injuries expeditiously.

Development and validation of novel inflammatory response-related gene signature for sepsis prognosis

Due to the low specificity and sensitivity of biomarkers in sepsis diagnostics,the prognosis of sepsis patient outcomes still relies on the assessment of clinical symptoms.Inflammatory response is crucial to sepsis onset and progression;however,the significance of inflammatory response-related genes(IRRGs)in sepsis prognosis is uncertain.This study developed an IRRG-based signature for sepsis prognosis and immunological function.The Gene Expression Omnibus(GEO)database was retrieved for two sepsis microarray datasets,GSE64457 and GSE69528,followed by gene set enrichment analysis(GSEA)comparing sepsis and healthy samples.A predictive signature for IRRGs was created using least absolute shrinkage and selection operator(LASSO).To confirm the efficacy and reliability of the new prognostic signature,Cox regression,Kaplan-Meier(K-M)survival,and receiver operating characteristic(ROC)curve analyses were performed.Subsequently,we employed the GSE95233 dataset to independently validate the prognostic signature.A single-sample GSEA(ssGSEA)was conducted to quantify the immune cell enrichment score and immune-related pathway activity.We found that more gene sets were enriched in the inflammatory response in sepsis patient samples than in healthy patient samples,as determined by GSEA.The signature of nine IRRGs permitted the patients to be classified into two risk categories.Patients in the low-risk group showed significantly better 28-d survival than those in the high-risk group.ROC curve analysis corroborated the predictive capacity of the signature,with the area under the curve(AUC)for 28-d survival reaching 0.866.Meanwhile,the ss GSEA showed that the two risk groups had different immune states.The validation set and external dataset showed that the signature was clinically predictive.In conclusion,a signature consisting of nine IRRGs can be utilized to predict prognosis and influence the immunological status of sepsis patients.Thus,intervention based on these IRRGs may become a therapeutic option in the future.