The present study observed the dynamic expression of CD133,nuclear factor-κB and glial fibrillary acidic protein in the hippocampal CA3 area of the experimental posttraumatic epilepsy rats to investigate whether glio...The present study observed the dynamic expression of CD133,nuclear factor-κB and glial fibrillary acidic protein in the hippocampal CA3 area of the experimental posttraumatic epilepsy rats to investigate whether gliosis occurs after posttraumatic epilepsy.CD133 and nuclear factor-κB expression was increased at 1 day after posttraumatic epilepsy,peaked at 7 days,and gradually decreased up to 14 days,as seen by double-immunohistochemical staining.Glial fibrillary acidic protein/nuclear factor-κB double-labeled cells increased with time and peaked at 14 days after posttraumatic epilepsy.Results show that activation of hippocampal neural stem cells and glial proliferation after posttraumatic epilepsy-induced oxidative stress increases hippocampal glial cell density.展开更多
基金the Science and Technology Foundation of Fujian Province, No. 2007F5045the Program for New Century Excellent Talents in Fujian Province University, No. NCETFJ-0702
文摘The present study observed the dynamic expression of CD133,nuclear factor-κB and glial fibrillary acidic protein in the hippocampal CA3 area of the experimental posttraumatic epilepsy rats to investigate whether gliosis occurs after posttraumatic epilepsy.CD133 and nuclear factor-κB expression was increased at 1 day after posttraumatic epilepsy,peaked at 7 days,and gradually decreased up to 14 days,as seen by double-immunohistochemical staining.Glial fibrillary acidic protein/nuclear factor-κB double-labeled cells increased with time and peaked at 14 days after posttraumatic epilepsy.Results show that activation of hippocampal neural stem cells and glial proliferation after posttraumatic epilepsy-induced oxidative stress increases hippocampal glial cell density.
