The high incidence of catheter-associated urinary tract infections,which are dominated by drugresistant bacteria,has attracted an increasing number of researchers interested in solving this public health problem.The p...The high incidence of catheter-associated urinary tract infections,which are dominated by drugresistant bacteria,has attracted an increasing number of researchers interested in solving this public health problem.The purpose of this study was to explore the killing effect of lowtemperature air plasma(LTAP)on extended-spectrum beta-lactamase-producing Escherichia coli and high level gentamycin resistance enterococci under two simulated environments in vitro.The results showed that the survival rate of these two kinds of bacteria decreased to less than20%after being treated by LTAP in different environments for 5 min.A comparison of the LTAP treatments showed that the killing efficacy of the two kinds of bacteria in the early stage(0-1 min)was up to 50%.Moreover,the results of transmission electron microscopy,reactive nitrogen species measurement,and a temperature test indicated that the bactericidal effect of the LTAP treatment on the two kinds of bacteria worked through the destruction of the ribosome and other organelles inside the bacteria,rather than the thermal effect,to achieve sterilization.展开更多
Dear Editor,Great progress has been made in the clinical use of photodynamic therapy(PDT)for the treatment of patients with superficial tumors[1].However,cancer recurrence and metastasis have limited the application o...Dear Editor,Great progress has been made in the clinical use of photodynamic therapy(PDT)for the treatment of patients with superficial tumors[1].However,cancer recurrence and metastasis have limited the application of PDT in the treatment of solid tumors and advanced cancers.In this context,combining PDT with other complementary immunotherapy regimens may overcome these limitations of PDT[2].展开更多
The main oil source in western Qaidam Basin is the Paleogene saline lacustrine source rocks.Traditionally,it was considered that these source rocks were characterized by low abundance and poor type of organic matter a...The main oil source in western Qaidam Basin is the Paleogene saline lacustrine source rocks.Traditionally,it was considered that these source rocks were characterized by low abundance and poor type of organic matter as well as limited oil generation potential,but this poor source rock condition was very inconsistent with good hydrocarbon exploration results.A previous study has just confirmed that this area develops high-quality source rocks,which is of great significance for recognizing potential of hydrocarbon resource and consolidating confidence to search large and medium-sized oil and gas fields in western Qaidam Basin.Based on fine geochemical analysis of source rocks,petrology,element geochemistry and organic geochemistry are applied to discuss development conditions of high-quality source rocks in this area.The results showed that the saline lacustrine sediments in western Qaidam Basin were deposited in relatively shallow and quiet water with relatively high salinity and low nutrient content;influenced by the drought and cold climate,the terrigenous supply of fresh water was limited,and few aquatic organisms were developed.Good preservation condition is favorable for rapid preservation of oil generating biomass(such as aquatic organisms),to form source rocks rich in hydrogen element with high soluble organic matter content;but relatively lower paleo-productivity makes organic matter abundance lower than that in the eastern saline lacustrine basins.The semi-deep lake,with relatively low salinity and abundant nutrients,is the most favorable are for development of high-quality source rocks;the source rocks have large thickness in the sedimentary depression areas,but due to high water salinity and far away from the provenance area,the water stratification was obvious,so it have moderate to high organic matter abundance.展开更多
Photocatalytic optical fibers are promising for the degradation of gaseous and volatile pollutants in air due to their high specific surface area,high light utilization efficiency,easy regeneration,and sustainability....Photocatalytic optical fibers are promising for the degradation of gaseous and volatile pollutants in air due to their high specific surface area,high light utilization efficiency,easy regeneration,and sustainability.In particular,photocatalytic optical fibers have proven highly useful for the removal and conversion of different kinds of air pollutants in air.However,these fibers suffer from low photocatalytic degradation efficiencies.In this review,we have focused on introducing photocatalytic quartz optical fibers and photocatalytic plastic optical fibers for the degradation and transformation of gas-phase air pollutants.The principle of photocatalytic optical fibers and main methods for improving their photocatalytic and light utilization efficiencies based on semiconductor photocatalytic coatings are summarized.Moreover,the Langmuir-Hinshelwood kinetic rate equation was summarized to analyze the photocatalytic reduction of gaseous pollutants.Finally,an outlook on the future of photocatalytic optical fibers toward the removal and conversion of gaseous air pollutants is discussed.展开更多
In this study,the aerodynamic performance of flapping wings using a parallel motion was investigated and compared with the insect-like‘‘fan-sweep’’motion,and the effect of adding a slit to the wings was analyzed.F...In this study,the aerodynamic performance of flapping wings using a parallel motion was investigated and compared with the insect-like‘‘fan-sweep’’motion,and the effect of adding a slit to the wings was analyzed.First,numerical simulations were performed to analyze the wing aerodynamics of two flapping motions with equivalent stroke amplitudes over a range of pitching angles based on computational fluid dynamics(CFD).The simulation results indicated that flapping wings with a rapid and short parallel motion achieved better lift and efficiency than those of the fan-sweep motion while maintaining the same aerodynamic characteristics regarding stall delay and leading-edge vortices.For a parallel motion with a pitching angle of 25◦and 100 mm stroke amplitude,the wings generated an average lift of 8.4 gf with a lift-to-drag ratio of 1.06,respectively,which were 1.8%and 26%greater than those of the fan-sweep motion with a corresponding 96◦stroke amplitude.This situation was reversed when the pitching angle and stroke amplitude were increased to 45◦and 144◦for the fan-sweep motion,which was equivalent to the parallel motion with a 150 mm stroke amplitude.The slit effect in the parallel motion was also evaluated,and the CFD results indicated that a slit width of 1 mm(1/50 wing chord)increased the lift of the wing by approximately 27%in the case of the 150 mm stroke amplitude.Further,the slit width slightly influenced the lift and aerodynamic efficiency.展开更多
Recent studies suggest that Hypocretin (HCRT, Orexin) are involved in stress regulation of depression through the hypothalamic-pituitary-adrenal (HPA) axis. However, the molecular mechanism by which Hypocretin regulat...Recent studies suggest that Hypocretin (HCRT, Orexin) are involved in stress regulation of depression through the hypothalamic-pituitary-adrenal (HPA) axis. However, the molecular mechanism by which Hypocretin regulate neurobiological responses is unknown. Herein, the effects of chronic stress on the epigenetic modification of HCRT and its association with depression were explored with regard to a potential role in cancer progression. In the study, Sprague Dawley (SD) rats were used to establish an animal model of cancer with depression by administrating n-nitrosodiethylamine (DEN) and chronic unpredictable mild stress (CUMS). RNA-sequencing was used to detect differentially expressed genes in the hippocampus of rats and quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate the results of RNA-sequencing. The status of HCRT promoter methylation was assessed by methylation specific polymerase chain reaction. Behavioral tests showed that rats exposed to CUMS had significant depressive-like behaviors. The number of liver tumors and tumor load in depressed rats exposed to CUMS was higher than in SD rats without CUMS. RNA-sequencing revealed that HCRT was one of the most siginificantly downregulated gene in the hippocampus of SD rats with CUMS compared to non-stressed group, which was validated by qRT-PCR. HCRT mRNA expression was downregulated and the promoter for HCRT was hyper-methylated in those with depression. These results identified a critical role for chronic psychological stressors in tumorigenesis and cancer progression, via epigenetic HCRT downregulation. Such epigenetic downregulation may be the molecular basis for the association of cancer with depression.展开更多
文摘The high incidence of catheter-associated urinary tract infections,which are dominated by drugresistant bacteria,has attracted an increasing number of researchers interested in solving this public health problem.The purpose of this study was to explore the killing effect of lowtemperature air plasma(LTAP)on extended-spectrum beta-lactamase-producing Escherichia coli and high level gentamycin resistance enterococci under two simulated environments in vitro.The results showed that the survival rate of these two kinds of bacteria decreased to less than20%after being treated by LTAP in different environments for 5 min.A comparison of the LTAP treatments showed that the killing efficacy of the two kinds of bacteria in the early stage(0-1 min)was up to 50%.Moreover,the results of transmission electron microscopy,reactive nitrogen species measurement,and a temperature test indicated that the bactericidal effect of the LTAP treatment on the two kinds of bacteria worked through the destruction of the ribosome and other organelles inside the bacteria,rather than the thermal effect,to achieve sterilization.
基金This research was supported by the Fundamental Research Funds for the Central Universities of China under Grant No.3162020ZYKC05Beijing Social Science Funds under Grant No.19YYC017.
基金supported by the National Basic Research Program of China(973 project,grant number:2014CB542902)Tianjin Hongrentang Pharmaceutical Co.,Ltd.,Tianjin,China(grant number:HX202016)。
基金Yang Hao received finacial support from the China Scholarship and Jilin Province Chinese Postdoctoral International Exchange Program(YJ20220406)Zili Gu,Zhenfeng Yu and Sen Ma received financial support from the China Scholarship Council,and Peter ten Dijke received funding from Cancer Genomics Centre NetherlandsTimo Schomann and Alireza Haghparast received funding from the European Commission,grants H2020-MSCA-RISE CANCER(777682)and H2020-WIDESPREAD-05-2017-Twinning SIMICA(852985).
文摘Dear Editor,Great progress has been made in the clinical use of photodynamic therapy(PDT)for the treatment of patients with superficial tumors[1].However,cancer recurrence and metastasis have limited the application of PDT in the treatment of solid tumors and advanced cancers.In this context,combining PDT with other complementary immunotherapy regimens may overcome these limitations of PDT[2].
基金The work was supported by the Petrochina Science and Technology Major Project(2016E-0101).
文摘The main oil source in western Qaidam Basin is the Paleogene saline lacustrine source rocks.Traditionally,it was considered that these source rocks were characterized by low abundance and poor type of organic matter as well as limited oil generation potential,but this poor source rock condition was very inconsistent with good hydrocarbon exploration results.A previous study has just confirmed that this area develops high-quality source rocks,which is of great significance for recognizing potential of hydrocarbon resource and consolidating confidence to search large and medium-sized oil and gas fields in western Qaidam Basin.Based on fine geochemical analysis of source rocks,petrology,element geochemistry and organic geochemistry are applied to discuss development conditions of high-quality source rocks in this area.The results showed that the saline lacustrine sediments in western Qaidam Basin were deposited in relatively shallow and quiet water with relatively high salinity and low nutrient content;influenced by the drought and cold climate,the terrigenous supply of fresh water was limited,and few aquatic organisms were developed.Good preservation condition is favorable for rapid preservation of oil generating biomass(such as aquatic organisms),to form source rocks rich in hydrogen element with high soluble organic matter content;but relatively lower paleo-productivity makes organic matter abundance lower than that in the eastern saline lacustrine basins.The semi-deep lake,with relatively low salinity and abundant nutrients,is the most favorable are for development of high-quality source rocks;the source rocks have large thickness in the sedimentary depression areas,but due to high water salinity and far away from the provenance area,the water stratification was obvious,so it have moderate to high organic matter abundance.
基金the National Natural Science Foundation of China(NSFC)(Nos.51876018and 52176178)the Innovation research group of universities in Chongqing(No.CXQT21035)+2 种基金the Postgraduate Research Innovation Project of Chongqing University of Technology(No.ycx20192047)the Postgraduate Research Innovation Project of Chongqing(Nos.CYS18309 and CYS19318)the Science and Technology Research Project of Chongqing Education Commission(No.KJQN201801126)。
文摘Photocatalytic optical fibers are promising for the degradation of gaseous and volatile pollutants in air due to their high specific surface area,high light utilization efficiency,easy regeneration,and sustainability.In particular,photocatalytic optical fibers have proven highly useful for the removal and conversion of different kinds of air pollutants in air.However,these fibers suffer from low photocatalytic degradation efficiencies.In this review,we have focused on introducing photocatalytic quartz optical fibers and photocatalytic plastic optical fibers for the degradation and transformation of gas-phase air pollutants.The principle of photocatalytic optical fibers and main methods for improving their photocatalytic and light utilization efficiencies based on semiconductor photocatalytic coatings are summarized.Moreover,the Langmuir-Hinshelwood kinetic rate equation was summarized to analyze the photocatalytic reduction of gaseous pollutants.Finally,an outlook on the future of photocatalytic optical fibers toward the removal and conversion of gaseous air pollutants is discussed.
基金funding organizations in China:the National Key Research and Development Program of China(Grant No.2018YFB1305400)the National Natural Science Foundation of China(Grant Nos.62173212 and 11972079).
文摘In this study,the aerodynamic performance of flapping wings using a parallel motion was investigated and compared with the insect-like‘‘fan-sweep’’motion,and the effect of adding a slit to the wings was analyzed.First,numerical simulations were performed to analyze the wing aerodynamics of two flapping motions with equivalent stroke amplitudes over a range of pitching angles based on computational fluid dynamics(CFD).The simulation results indicated that flapping wings with a rapid and short parallel motion achieved better lift and efficiency than those of the fan-sweep motion while maintaining the same aerodynamic characteristics regarding stall delay and leading-edge vortices.For a parallel motion with a pitching angle of 25◦and 100 mm stroke amplitude,the wings generated an average lift of 8.4 gf with a lift-to-drag ratio of 1.06,respectively,which were 1.8%and 26%greater than those of the fan-sweep motion with a corresponding 96◦stroke amplitude.This situation was reversed when the pitching angle and stroke amplitude were increased to 45◦and 144◦for the fan-sweep motion,which was equivalent to the parallel motion with a 150 mm stroke amplitude.The slit effect in the parallel motion was also evaluated,and the CFD results indicated that a slit width of 1 mm(1/50 wing chord)increased the lift of the wing by approximately 27%in the case of the 150 mm stroke amplitude.Further,the slit width slightly influenced the lift and aerodynamic efficiency.
基金The study was supported by the National Natural Science Foundation of China (NSFC) (No.#81872380)the Opening Foundation of Chongqing Key Laboratory of Molecular Oncology and Epigenetics.
文摘Recent studies suggest that Hypocretin (HCRT, Orexin) are involved in stress regulation of depression through the hypothalamic-pituitary-adrenal (HPA) axis. However, the molecular mechanism by which Hypocretin regulate neurobiological responses is unknown. Herein, the effects of chronic stress on the epigenetic modification of HCRT and its association with depression were explored with regard to a potential role in cancer progression. In the study, Sprague Dawley (SD) rats were used to establish an animal model of cancer with depression by administrating n-nitrosodiethylamine (DEN) and chronic unpredictable mild stress (CUMS). RNA-sequencing was used to detect differentially expressed genes in the hippocampus of rats and quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate the results of RNA-sequencing. The status of HCRT promoter methylation was assessed by methylation specific polymerase chain reaction. Behavioral tests showed that rats exposed to CUMS had significant depressive-like behaviors. The number of liver tumors and tumor load in depressed rats exposed to CUMS was higher than in SD rats without CUMS. RNA-sequencing revealed that HCRT was one of the most siginificantly downregulated gene in the hippocampus of SD rats with CUMS compared to non-stressed group, which was validated by qRT-PCR. HCRT mRNA expression was downregulated and the promoter for HCRT was hyper-methylated in those with depression. These results identified a critical role for chronic psychological stressors in tumorigenesis and cancer progression, via epigenetic HCRT downregulation. Such epigenetic downregulation may be the molecular basis for the association of cancer with depression.
