Clarifying the relationship between PM2.5 and ozone complex pollution and synoptic patterns in a typical petrochemical city in the Bohai Rim region of China:Implications for air pollution forecasting and control

Meteorological conditions are vital to PM_(2.5)and ozone(O_(3))complex pollution.Herein,the T-mode principal com-ponent analysis method was employed to objectively classify the 925-hPa geopotential height field of Dongying from 2017 to 2022.Synoptic patterns associated with four pollution types-namely,PM_(2.5)-only pollution,O_(3)-only pollution,Co-occurring of PM_(2.5)and O_(3)pollution,Non-occurring of PM_(2.5)and O_(3)pollution-were characterized at different time scales.The results indicated that synoptic classes conducive to PM_(2.5)-only pollution were“high-pressure top front”,“offshore high-pressure rear”,and“high-pressure inside”,while those conducive to O_(3)-only pollution were“offshore high-pressure rear”,“subtropical high”,and“high and low systems”.The Co-occurring of PM_(2.5)and O_(3)pollution were influenced by high pressure,and the Non-occurring of PM_(2.5)and O_(3)pollution were linked to precipitation and strong northerly winds.The variation in dominant synoptic patterns is crucial in the frequency changes of the four pollution types,which was further validated through the analysis of typical cases.Under the favorable meteorological conditions of high-pressure control with strong northerly winds or a subtropical high and inverted trough both with strong precipitation,there is potential to achieve coordinated control of PM_(2.5)and O_(3)in Dongying.Additionally,measures like artificially manipulating local humidity could be adopted to alleviate pollution levels.This study reveals the importance of comprehending the meteorological factors contributing to the formation of PM_(2.5)and O_(3)complex pollution for the improvement of urban air quality in the Bohai Rim region of China when emissions are high and the concentration of air pollutants exhibits high meteorological sensitivity.

Significant contributions of the petroleum industry to volatile organic compounds and ozone pollution:Insights from year-long observations in the Yellow River Delta

The petroleum industry is a significant source of anthropogenic volatile organic compounds(VOCs),but up to now,its exact impact on urban VOCs and ozone(O_(3))remains unclear.This study conducted year-long VOC ob-servations in Dongying,China,a petroleum industrial region.The VOCs from the petroleum industry(oil and gas volatilization and petrochemical production)were identified by employing the positive matrix factorization model,and their contribution to O_(3) formation was quantitatively evaluated using an observation-based chemical box model.The observed annual average concentration of VOCs was 68.6±63.5 ppbv,with a maximum daily av-erage of 335.3 ppbv.The petroleum industry accounted for 66.5%of total VOCs,contributing 54.9%from oil and gas evaporation and 11.6%from petrochemical production.Model results indicated that VOCs from the petroleum industry contributed to 31%of net O_(3) production,with 21.3%and 34.2%contributions to HO_(2)+NO and RO_(2)+NO pathways,respectively.The larger impact on the RO_(2) pathway is primarily due to the fact that OH+VOCs ac-count for 86.9%of the primary source of RO_(2).This study highlights the critical role of controlling VOCs from the petroleum industry in urban O_(3) pollution,especially those from previously overlooked low-reactivity alkanes.

Efficacy and safety of anlotinib plus S-1as thirdly-line or later-line treatmentin advanced non-small cell lung cancer

Objective Anlotinib,an oral vascular endothelial growth factor receptor 2(VEGFR2)inhibitor,has confirmed antitumor activity in lung cancer in both in vitro and in vivo assays,and has been recommended as third-line treatment agent in non-oncogene driven non-small cell lung cancer(NSCLC).This prospective study aimed to investigate the efficacy and safety of anlotinib plus S-1 for third-or later-line treatment in patients with advanced NSCLC.Methods Patients with histologically or cytologically confirmed NSCLC,and documented disease progression following second-line chemotherapy,and/or epidermal growth factor receptor-tyrosine kinase inhibitor(EGFR-TKI)treatment were enrolled in this study.The patients were treated anlotinib(8 mg daily d 1–14)and S-1(60 mg/m^2 d 1–14)and the treatment was repeated every 3 weeks.Treatment was continued until disease progression or unacceptable toxicity occurred.The objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS),and adverse events(AEs)were reviewed and evaluated.Results Forty-one patients were enrolled in the study between June 2018 and December 2018.The total ORR and DCR were 26.8%and 80.5%,respectively.The median PFS was 5.2 months[95%confidence interval(CI),3.9 to 6.6 months].In the univariate analysis,there was a significant difference in the median PFS between patients with brain metastases and those without brain metastases(4.8 months vs 5.9 months,respectively;P=0.039).The Eastern Cooperative Oncology Group(ECOG)performance status(P=0.002),lines of therapy(P=0.015),and therapeutic evaluation(P=0.014)were independent factors that influenced PFS.The most common AEs were hypertension,proteinuria,myelosuppression,gastrointestinal reactions,fatigue,and mucositis.Conclusion Anlotinib plus S-1 is an effective and safe regimen for advanced NSCLC as third-or later-line therapy.

Effect of substrate orientations on the electrochemical and localized corrosion behavior of a quad-layer Al alloy composite

Electrochemical and localized corrosion behavior of a 4045/7072/3003 M/4045 Al alloy composite in 3.5 wt.%NaCl solution was investigated from cross-sectional and plane directions by electrochemical impedance spectroscopy,polarization curves,and high-resolution microscopic examination.Plane directions showed higher corrosion resistance than the cross-sectional surface,with almost all localized corrosion initiated from Si-containing inclusions.The cross-section showed a complex galvanic effect among the four layers,the galvanic coupling between 4045/7072 accelerated the dissolution of 7072 because 7072 served as the anode,however,the galvanic coupling between 3003 M/4045 protected 4045 from corrosion,indicating that 3003 M served as the anode.

Research on ozone formation sensitivity based on observational methods:Development history,methodology,and application and prospects in China

Observation-based method for O_(3)formation sensitivity research is an important tool to analyze the causes of ground-level O_(3)pollution,which has broad application potentials in determining the O_(3)pollution formation mechanism and developing prevention and control strategies.This paper outlined the development history of research on O_(3)formation sensitivity based on observational methods,described the principle and applicability of the methodology,summarized the relative application results in China and provided recommendations on the prevention and control of O_(3)pollution in China based on relevant study results,and finally pointed out the shortcomings and future development prospects in this field in China.The overview study showed that the O_(3)formation sensitivity in some urban areas in China in recent years presented a gradual shifting tendency from the VOC-limited regime to the transition regime or the NO_(x)-limited regime due to the implementation of the O_(3)precursors emission reduction policies;O_(3)pollution control strategies and precursor control countermeasures should be formulated based on local conditions and the dynamic control capability of O_(3)pollution control measures should be improved.There are still some current deficiencies in the study field in China.Therefore,it is recommended that a stereoscopic monitoring network for atmospheric photochemical components should be further constructed and improved;the atmospheric chemical mechanisms should be vigorously developed,and standardized methods for determining the O_(3)formation sensitivity should be established in China in the near future.

非参数选择机制下二值因变量的内生选择模型的估计

本文基于非参数的选择机制,探讨一类二值因变量的内生样本选择模型的估计问题.本文在模型设定时,既不对方程中误差项的分布作具体假设,也不设定选择方程中的函数形式,从而大大减少了模型误设的可能性.本文给出模型的识别条件,并提出两步半参数极大似然估计方法,其中第一步是针对选择方程进行非参数回归,第二步是基于选择方程中的估计结果,针对结果方程中的参数进行估计.本文利用控制函数方法来解决模型中可能.存在的内生性,并给出估计量的一致性和渐近正态性质.通过Monte Carlo模拟与文献中其他方法进行了比较,结果表明,本文的方法在模型稳健性方面具有较为明显的优势.最后,将估计方法应用于研究劳动力市场上女性的就业模式这一社会现实问题,体现了本文方法的实用价值.

Strigolactones and Brassinosteroids Antagonistically Regulate the Stability of the D53-OsBZR1 Complex to Determine FC1 Expression in Rice Tillering

Rice tillering,a key architecture trait determ ining grain yield,is highly regulated by a class of newly identified phytohorm ones,strigolactones(SLs).How ever,the whole SL signaling pathw ay from the receptor to dow nstream transcription factors to finally inhibit tillering remains unrevealed.In this study,we first found that brassinosteroids(BRs)strongly enhance tillering by prom oting bud outgrow th in rice,which is largely different from the function of BRs in Arabidopsis.Genetic and biochem ical analyses indicated that both the SL and BR signaling pathw ays control rice tillering by regulating the stability of D53 and/or the OsBZR1 RLA1-DLT module,a transcriptional complex in the rice BR signaling pathway.We further found that D53 interacts with OsBZR1 to inhibit the expression of FC1,a local inhibitor of tillering,and that this inhibition depends on direct DNA binding by OsBZR1,which recruits D53 to the FC1 promoter in rice buds.Taken together,these findings uncover a mechanism illustrating how SLs and BRs coordinately regulate rice tillering via the early responsive gene FC1.

Sodium humate accelerates cutaneous wound healing by activating TGF-β/Smads signaling pathway in rats

Sodium humate(HA-Na) has been topically used as a wound healing and anti-inflammatory agent in folk medicine. In the present study, HA-Na was investigated for cutaneous wound healing in Sprague–Dawley rats. HA-Na solution(1.0%, w/v) was topically administered to rats undergoing excision wound models. Healing was assessed with a recombinant bovine basic fibroblast growth factor for external use as positive control. Wound healing rates were calculated on Day 3, 6, 9, 14 and 21 after injury, and tissues were also harvested after the same intervals for histological analysis. In addition, tissue hydroxyproline levels were measured. Furthermore, m RNA levels and protein expressions of transforming growth factor-β1, 2, 3(TGF-β1, 2, 3) were determined by RT-PCR and western blot. Protein expression levels of Smad-2,-3,-4 and-7 were also detected by western blot. Our study demonstrates that HA-Na has the capacity to promote wound healing in rats via accelerated wound contraction and increased hydroxyproline content. More importantly, these wound healing effects of HA-Na might be mediated through the TGF-β/Smad signaling pathway. HA-Na may be an effective agent for enhanced wound healing.

A review of atmospheric benzene homologues in China: Characterization, health risk assessment, source identification and countermeasures

Benzene homologues are important chemical precursors to the formation of ground-level ozone and secondary organic aerosol(SOA) in the atmosphere,in addition,some toxic species are harmful to human health.Strict countermeasures have been taken to fight air pollution since 2013,and total amount control of volatile organic compounds is being promoted in China at present.Therefore,it is important to understand the pollution situation and the control status of ambient benzene homologues in China.This paper reviews research progress from published papers on pollution characteristics,atmospheric photochemical reactivity,health risk assessment and source identification of ambient benzene homologues in recent years in China,and also summarizes policies and countermeasures for the control of ambient benzene homologues and the relevant achievements.The total ambient levels of benzene,toluene,ethylbenzene and xylenes(BTEX) shows a declining tendency from 2001 to 2016 in China.The mass concentrations of BTEX are generally higher in southern regions than in northern regions,and they present vertical decreasing variation characteristics with increasing altitude within the height range of about 5500 m.Toluene has the highest ozone formation potential and SOA formation potential both in urban areas and background areas,while benzene poses an obvious carcinogenic risk to the exposed adult populations in urban areas.Source identification of ambient benzene homologues suggested that local governments should adopt differentiated control strategies for ambient benzene homologues.Several recommendations are put forward for future research and policy-making on the control of ambient benzene homologues in China.

BES1 Functions as the Co-regulator of D53-like SMXLs to Inhibit BRC1 Expression in Strigolactone-Regulated Shoot Branching in Arabidopsis

Shoot branching,determining plant architecture and crop yield,is critically controlled by strigolactones(SLs).However,how SLs inhibit shoot branching after its perception by the receptor complex remains largely obscure.In this study,using the transcriptomic and genetic analyss as well as biochemical studies,we reveal the key role of BES1 in the SL-regulated shoot branching.Wedemonstrate that BES1 and D53-like SMXLs,the substrates of SL receptor complex D14–MAX2,interact with each other to inhibit BRC1 expression,which specifically triggers the SL-regulated transcriptional network in shoot branching.BES1 directly binds the BRC1 promoter and recruits SMXLs to inhibit BRC1 expression.Interestingly,despite being the shared component by SL and brassinosteroid(BR)signaling,BES1 gains signal specificity through different mechanisms in response to BR and SL signals.

Meta-analysis of the effect of low-level occupational benzene exposure on human peripheral blood leukocyte counts in China

To investigate the effect of low-level occupational benzene exposure on human peripheral blood leukocyte counts of the workers,domestic and foreign published research data on the change of human peripheral blood leukocyte counts under low-level occupational benzene exposure from January 1990 to December 2020 were collected and analyzed.According to the literature inclusion and exclusion criteria,18 independent studies from 12 publications were selected for meta-analysis to explore the effect of low-level occupational benzene exposure on human peripheral blood leukocyte counts.The results showed that the peripheral blood leukocyte counts abnormal rates of low-level occupational benzene exposure group were higher than those of the control group,and the difference was statistically significant.Low-level occupational benzene exposure could result in a relatively higher abnormal rate of peripheral blood leukocyte counts in the exposed population,indicating that low-level occupational benzene exposure at workplaces specified by the current benzene occupational exposure limit in China would affect the peripheral blood leukocyte counts of the workers,thus benzene with concentrations under the limit in the ambient air of workplace could be still harmful to the health of the exposed workers.The results of this study could provide a scientific basis for future revision of the benzene occupational exposure limit in China,and could also be a reference for the formulation of environmental standard concerning benzene in China in the future.