Evaluation and Genetic Classification of Rice Germplasm Resources Resistant to Rice Blast

[ Objective] This study aimed to explore rice germplasm resources resistant to rice blast and provide theoretical basis for the modification of rice blast- resistant germplasm resources. [ Method] The resistance of 120 rice materials to rice blast was identified at three experimental areas. [ Result] The resistance of 120 experimental materials was at grade 0 -9 to panicle blast in Hainan Province, at grade 0 -9 to seedling blast in Fujian Province and at grade 3 -9 topanicle blast in Guangxi Zhuang Autonomous Region. Analysis of correlations between agronomic traits and rice blast resistance indicated that the resistance of experimental materials could not be simply determined based on agronomic traits. Furthermore, 61 published SSR makers closely linked to rice blast were selected and synthe- sized for genotypic analysis of 120 experimental materials. The results of cluster analysis preliminarily divided 120 germplasms into resistant varieties and susceptible varieties. [ Conclusion] These rice germplasm resources are of important value for breeding new materials resistant to rice blast.

A Probe into the Popularization Ways of Early Childhood Educational Drama in Kindergartens

Early childhood education drama lessons can be simply explained as educationally meaningful drama training for children before the compulsory education stage.Its educational characteristics are preschool children as the main body of education,paying attention to the preservation and protection of children’s nature,and through educational drama Symbolic games,imagination games,pretend games,social drama games and other links further expand children's social cognition.Its purpose is to inspire the development of students in moral education through the art form of educational drama,and use drama as a carrier to further liberate children’s nature,enlighten children’s minds,improve children’s personality and through participating in drama appreciation,creation,performance,and imitation.Play a vital role in children's creativity and other aspects.However,there are still many huge problems in the general acceptance and large-scale promotion of early childhood education drama classes in our inland cities.I have discovered the current promotion of kindergarten education drama classes by exploring the promotion methods of early childhood education drama classes in kindergartens.The biggest problem is the lack of professional teachers'resources and the kindergarten's insufficient understanding of the importance of educational drama.

A glutathione-triggered precision explosive system for improving tumor chemosensitivity

Stimuli-responsive delivery systems hold promise in cancer treatments.However,their application potential has been limited due to undesirable drug leaking during blood circulation and inefficient therapeutic efficacy in tumors,resulting in undesirable therapeutic outcomes.Herein,we have developed a novel redox-sensitive pegylated phospholipid,termed as DOPE-SS-PEG,which can form a glutathione(GSH)-triggered precision explosive system(GPS)for simultaneously improving circulation stability,tumor specificity,and chemosensitivity,leading to explosive anticancer effects.GPS is constructed of liposomal doxorubicin(DOX)functionalized with DOPE-SS-PEG and MnO_(2) nanoparticles,which can protect liposome structure in the presence of serum GSH(20μM),whereas converts to cationic liposome in response to intracellular GSH(10 mM),thereby enhancing circulation stability,tumor specificity,endosomal escape,and cytoplasmic delivery.Importantly,GPS can not only generate oxygen to relieve hypoxia and consequently enhance chemosensitivity,but quench GSH antioxidability to elevate the accruement of intracellular reactive oxygen species(ROS),leading to an explosion of oxidative stress induced cell injury.Particularly,in vivo studies show that GPS selectively accumulates in tumor tissues,effectively inhibits tumor growth,exhibits minimal systemic adverse effects,and consequently prolongs the survival time of tumor-bearing mice.Therefore,GPS is a unique stimuli-responsive treatment with programmed and on-demand drug delivery,as well as explosive therapeutic efficacy,and provides an intelligent anticancer treatment.