甘肃省文县白马藏族民歌文化传承路径研究

传统民歌是我国传统文化的一部分,也是民族文化的重要表现形式,研究民歌文化对民族文化的传承、保护和发展具有重要作用。本文通过对甘肃省文县白马藏族民歌文化传承现状调查研究,分析了目前民歌文化传承存在的问题,并提出了一些发展的建议。目前存在的问题主要是民众多数参与民歌文化活动,但参与频度较低;民歌文化整体发展失衡,部分项目逐渐流失;传承内容单一;传承媒介欠缺及传承人缺乏;文化传承保障措施落实不到位等。文章分别从传承人层面、民众层面、和政府层面提出传承路径,以提高传统民歌文化保护意识和责任、加强创新发展、借助媒体推广民歌文化、培养民歌人才、增加文化传承活力、推动乡村振兴。

Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1

Our previous studies have shown that infection with the gp120 V3 loop can cause human immunodeficiency virus-1 associated neurocognitive disorders. Curcumin has been shown to improve these effects to some degree, but the precise mechanisms remain unknown. The present study analyzed the neuroprotective effect and mechanism of curcumin in relation to hippocampal neurons. Results showed that 1 nmol/L gp120 V3 loop suppressed the growth of synapses. After administration of 1 !umol/L curcumin, synaptic growth improved. Curcumin is neuroprotective against gp120 V3 loop-induced neuronal damage by inhibiting the activation of L-type calcium currents, relieving intracellular Ca^2＋ overload, promoting Bcl-2 expression, and inhibiting Bax activation. The effect of curcumin was identical to nimodipine, suggesting that curcumin has the same neuroprotective effects against gp120 V3 loop-induced neuronal damage.

Shock-Wave/Rail-Fasteners Interaction for Two Rocket Sleds in the Supersonic Flow Regime

Rocket sleds belong to a category of large-scale test platforms running on the ground.The applications can be found in many fields,such as aerospace engineering,conventional weapons,and civil high-tech products.In the present work,shock-wave/rail-fasteners interaction is investigated numerically when the rocket sled is in supersonic flow conditions.Two typical rocket sled models are considered,i.e.,an anti-D shaped version of the rocket sled and an axisymmetric slender-body variant.The dynamics for Mach number 2 have been simulated in the framework of a dynamic mesh method.The emerging shock waves can be categorized as head-shock,tailing-shock and reflected-shock.An unsteady large-scale vortex and related shock dynamics have been found for the anti-D shaped rocket sled.However,a quasi-steady flow state exists for the slender-body shaped rocket sled.It indicates that the axisymmetric geometry is more suitable for the effective production of rocket sleds.With the help of power spectral density analysis,we have also determined the characteristic frequencies related to shock-wave/rail-fasteners interaction.Furthermore,a harmonic phenomenon has been revealed,which is intimately related to a shock wave reflection mechanism.

Enzymatic Preparation of Fibroin-Based Functional Materials with Polyphenol Oxidase

Silk fibroin can be widely used in textile industry,medical and clinical fields,owing to its good biocompatibility,mechanical and physiological properties.Enzymatic modification of silk fibroins allows processing under mild conditions,offering a safer and cleaner alternative.Polyphenol oxidases(tyrosinase,laccase)can catalyze the oxidation of the phenolic hydroxyl group in tyrosine residues of

文化遗产视域下斯里兰卡文化认同构建研究--以文化三角为例

斯里兰卡历史悠久,其璀璨的文化遗产在历史语境中主线明显。本文以斯里兰卡阿努拉达普勒到康提的历史进程为线索,以文化三角为切面提炼斯里兰卡核心文化元素,具象文化遗产累叠之形制,分析人们对核心文化元素的具体实践和文化语法。在此基础上阐释僧伽罗人的文化认同机理,以盼能为文化认同和文化交流研究提供经典案例和借鉴。

Heavy metal removal from aqueous solutions by chitosan-based magnetic composite flocculants

In this study,three magnetic flocculants with different chelating groups,namely,carboxymethyl chitosan-modified Fe_(3)O_(4)flocculant(MC),acrylamide-grafted magnetic carboxymethyl chitosan flocculant(MCM),and 2-acrylamide-2-methylpropanesulfonic acid copolyacrylamide-grafted magnetic carboxymethyl chitosan flocculant(MCAA)were prepared,synthesized,and characterized by photopolymerization technology.They were applied to the flocculation removal of Cr(Ⅲ),Co(Ⅱ),and Pb(Ⅱ).The effect of flocculation condition on the removal performance of Cr(Ⅲ),Co(Ⅱ),and Pb(Ⅱ)was studied.Characterization results show that the three magnetic carboxymethyl chitosan-based flocculants have been successfully prepared with good magnetic induction properties.Flocculation results show that the removal rates of MC,MCM,and MCAA on Cr(Ⅲ)are 51.79%,82.33%,and 91.42%,respectively,under the conditions of 80 mg/L flocculant,pH value of 6,reaction time of 1.5 hr,G value of 200 s^(-1),and precipitation magnetic field strength of 120 mT.The removal rates of Co(Ⅱ)by MC,MCM,and MCAA are 54.33%,84.99%,and 90.49%,respectively.The removal rates of Pb(Ⅱ)by MC,MCM,and MCAA are 61.54%,91.32%,and 95.74%,respectively.MCAA shows good flocculation performance in composite heavy metal-simulated wastewater.The magnetic carboxymethyl chitosan-based flocculant shows excellent flocculation performance in removing soluble heavy metals.This research provides guidance and ideas for the development of efficient and low-cost flocculation technology to remove heavy metals in wastewater.

Co-metabolic and biochar-promoted biodegradation of mixed PAHs by highly efficient microbial consortium QY1

Polycyclic aromatic hydrocarbons(PAHs), typical representatives of the persistent organic pollutants(POPs), have become ubiquitous in the environment.In this study, a novel microbial consortium QY1 that performed outstanding PAHs-degrading capacity has been enriched.The degradation characteristics of single and mixed PAHs treated with QY1 were studied, and the effect of biochar on biodegradation of mixed PAHs and the potential of biochar in PAHs-heavy metal combined pollution bioremediation were also investigated.Results showed that, in single substrate system, QY1 degraded 94.5% of 500 mg/L phenanthrene(PHE) and 17.8% of 10 mg/L pyrene(PYR) after 7 days, while in PHE-PYR mixture system, the biodegradation efficiencies of PHE(500 mg/L) and PYR(10 mg/L) reached 94.0%and 96.2%, respectively, since PHE served as co-metabolic substrate to have significantly improved PYR biodegradation.Notably, with the cooperation of biochar, the biodegradations of PHE and PYR were greatly accelerated.Further, biochar could reduce the adverse impact of heavy metals(Cd^(2+), Cu^(2+), Cr_(2)O_(7)^(2-)) on PYR biodegradation remarkably.The sequencing analysis revealed that Methylobacterium, Burkholderia and Stenotrophomonas were the dominant genera of QY1 in almost all treatments, indicating that these genera might play key roles in PAHs biodegradation.Overall, this study provided new insights into the efficient bioremediation of PAHs-contaminated site.

Drug discovery of sclerostin inhibitors

Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-related diseases, making it a promising therapeutic target for the treatment of WNT-related bone diseases. Additionally, emerging evidence indicates that sclerostin contributes to the development of cancers, obesity, and diabetes, suggesting that it may be a promising therapeutic target for these diseases. Notably, cardiovascular diseases are related to the protective role of sclerostin. In this review, we summarize three distinct types of inhibitors targeting sclerostin, monoclonal antibodies, aptamers, and small-molecule inhibitors, from which monoclonal antibodies have been developed. As the first-in-class sclerostin inhibitor approved by the U.S. FDA,the monoclonal antibody romosozumab has demonstrated excellent effectiveness in the treatment of postmenopausal osteoporosis;however, it conferred high cardiovascular risk in clinical trials. Furthermore,romosozumab could only be administered by injection, which may cause compliance issues for patients who prefer oral therapy. Considering these above safety and compliance concerns, we therefore present relevant discussion and offer perspectives on the development of next-generation sclerostin inhibitors by following several ways, such as concomitant medication, artificial intelligence-based strategy, druggable modification, and bispecific inhibitors strategy.

Ionic/electronic conductivity regulation of n-type polyoxadiazole lithium sulfonate conductive polymer binders for high-performance silicon microparticle anodes

Low-cost silicon microparticles(SiMP),as a substitute for nanostructured silicon,easily suffer from cracks and fractured during the electrochemical cycle.A novel n-type conductive polymer binder with excellent electronic and ionic conductivities as well as good adhesion,has been successfully designed and applied for high-performance SiMP anodes in lithium-ion batteries to address this problem.Its unique features are attributed to the stro ng electron-withdrawing oxadiazole ring structure with sulfonate polar groups.The combination of rigid and flexible components in the polymer ensures its good mechanical strength and ductility,which is beneficial to suppress the expansion and contraction of SiMP s during the charge/discharge process.By fine-tuning the monomer ratio,the conjugation and sulfonation degrees of the polymer can be precisely controlled to regulate its ionic and electronic conductivities,which has been systematically analyzed with the help of an electrochemical test method,filling in the gap on the conductivity measurement of the polymer in the doping state.The experimental results indicate that the cell with the developed n-type polymer binder and SiMP(~0.5 μm) anodes achieves much better cycling performance than traditional non-conductive binders.It has been considered that the initial capacity of the SiMP anode is controlled by the synergetic effect of ionic and electronic conductivity of the binder,and the capacity retention mainly depends on its electronic conductivity when the ionic conductivity is sufficient.It is worth noting that the fundamental research of this wo rk is also applicable to other battery systems using conductive polymers in order to achieve high energy density,broadening their practical applications.

隐喻的开关:20世纪以来斯里兰卡华侨华人的文化认同机制研究

斯里兰卡与中国交往的历史源远流长,华侨华人是中斯双边友好往来的重要使者。文章在"旧背景"与"新时代"的情境下,阐释斯里兰卡老华人因同化和涵化出现原生民族特色和情感连接"隐形化",文化认同趋于"关闭"的现象;论述斯里兰卡老华人和新华侨在文化碰撞和交流中,以及在根基论和情境论作用下,老华人文化记忆被唤醒,从而引发从华人个体认同到社会认同的"开关"机理和"再建构"机制。以盼深化斯里兰卡华侨华人文化认同的研究,为南亚华侨华人研究提供经典案例。

Anthelmintics nitazoxanide protects against experimental hyperlipidemia and hepatic steatosis in hamsters and mice

Lipid metabolism disorders contribute to hyperlipidemia and hepatic steatosis.It is ideal to develop drugs simultaneous improving both hyperlipidemia and hepatic steatosis.Nitazoxanide is an FDA-approved oral antiprotozoal drug with excellent pharmacokinetic and safety profile.We found that nitazoxanide and its metabolite tizoxanide induced mild mitochondrial uncoupling and subsequently activated AMPK in Hep G2 cells.Gavage administration of nitazoxanide inhibited high-fat diet(HFD)-induced increases of liver weight,blood and liver lipids,and ameliorated HFD-induced renal lipid accumulation in hamsters.Nitazoxanide significantly improved HFD-induced histopathologic changes of hamster livers.In the hamsters with pre-existing hyperlipidemia and hepatic steatosis,nitazoxanide also showed therapeutic effect.Gavage administration of nitazoxanide improved HFD-induced hepatic steatosis in C57BL/6J mice and western diet(WD)-induced hepatic steatosis in Apoe-/-mice.The present study suggests that repurposing nitazoxanide as a drug for hyperlipidemia and hepatic steatosis treatment is promising.

NEW ERROR ESTIMATES FOR LINEAR TRIANGLE FINITE ELEMENTS IN THE STEKLOV EIGENVALUE PROBLEM

This paper is concerned with the finite elements approximation for the Steklov eigen- value problem on concave polygonal domain. We make full use of the regularity estimate and the characteristic of edge average interpolation operator of nonconforming Crouzeix- Raviart element, and prove a new and optimal error estimate in ｜｜ ｜｜o,δΩ for the eigenfunc- tion of linear conforming finite element and the nonconforming Crouzeix-Raviart element. Finally, we present some numerical results to support the theoretical analysis.

Chemical Synthesis of Structurally Defined Phosphorylated Ubiquitins Suggests Impaired Parkin Activation by Phosphorylated Ubiquitins with a Non-Phosphorylated Distal Unit

Mutations in genes encoding PINK1(PTEN-induced kinase 1)and Parkin(E3 ubiquitin ligase)are identified in familial Parkinson’s disease.However,it remains unclear whether the phosphorylated Ub chains activate wild-type Parkin(w-Parkin)or phosphorylated Parkin(p-Parkin),with the consequent expulsion of the damaged mitochondria.

Antioxidative MXene@GA‑Decorated Textile Assisted by Metal Ion for Efficient Electromagnetic Interference Shielding,Dual‑Driven Heating,and Infrared Thermal Camouflage

Two-dimensional transition metal carbide/nitride(MXene)-based textiles have been developed in many fields;however,the high sensitivity to oxidation and weak interfacial bonding hinder their applications.Herein,we present a strategy for the preparation of a highly antioxidative MXene@gallic acid(MXene@GA,MG)hybrid dispersion,and further covalently grafted it onto carboxylated cotton fabric through interaction with metal ions(Fe^(3+))for fabricating wearable multifunctional textiles.Due to the cross-linking effect of Fe^(3+)and the remarkable antioxidant activity of natural polyphenol GA,the MG coatings firmly adhere to the textile surfaces and can withstand conventional washing,exhibiting favorable service stability and potential application prospects.Moreover,the obtained MG-decorated textile has the inherent characteristics of good breathability,moisture permeability,flexibility,and biocompatibility of the original fabric,which are conducive to the wearability of smart devices.Furthermore,by utilizing the outstanding conductivity(~330 S/m)and photothermal convertibility of the MG coating,the functional textile achieves high electromagnetic interference(EMI)shielding efficiency(~35 dB),excellent dual-driven(Joule and solar)heating warmth retention,and infrared thermal camouflage.Due to the green and scalable preparation process,favorable durability,excellent comfort,and multifunctionality,the MG-decorated textiles are anticipated to be promising candidates for the next generation of smart wearable personal protective clothing.