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MKR转基因小鼠糖尿病发病特点的初步探讨 被引量:19
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作者 喻嵘 成细华 +3 位作者 胡伟 魏开春 yubin guo Jun-Li Liu 《中国实验动物学报》 CAS CSCD 2007年第5期333-337,共5页
目的观察骨骼肌胰岛素样生长因子-1受体及胰岛素受体的功能缺失(Mouse overexpressing adominant-negative IGF-I receptor specifically in muscle,MKR mouse)转基因2型糖尿病小鼠的血糖及其生长情况。方法由美国国立卫生研究院(NIH)... 目的观察骨骼肌胰岛素样生长因子-1受体及胰岛素受体的功能缺失(Mouse overexpressing adominant-negative IGF-I receptor specifically in muscle,MKR mouse)转基因2型糖尿病小鼠的血糖及其生长情况。方法由美国国立卫生研究院(NIH)授权使用引进的MKR鼠,经自然交配后繁殖的子代作为研究对象,制备尾组织基因组DNA,经聚合酶链反应得到扩增产物,1%琼脂糖凝胶电泳观察鉴定。同时对MKR鼠子代出生后的血糖、体重、胰岛素定时检测。同期采用昆明种小鼠或C57野生型小鼠进行对照。结果MKR鼠所有子代鼠均会出现长度为330 bp的DNA片段,表明该MKR鼠后代能稳定遗传。新生MKR鼠自出生3周开始,即出现显著的血糖增高,5周以后血糖则较稳定地维持在高水平。与对照组小鼠同期的血糖比较,差异具有非常显著性意义(P<0.01)。其体重增长随年龄的增长而减慢,至4月龄时体重基本稳定,但无下降趋势。MKR鼠在2月龄时即表现出显著的高胰岛素血症及糖耐量低下,与对照组小鼠同期比较,亦具有非常显著性意义(P<0.01)。MKR鼠在生长过程中无自然死亡发生。结论MKR鼠是至今为止一种非常良好的2型糖尿病的动物模型。 展开更多
关键词 2型糖尿病 小鼠 转基因技术 胰岛素样生长因子-1受体 胰岛素受体
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Spatio-spectral dynamics of soliton pulsation with breathing behavior in the anomalous dispersion fiber laser
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作者 韩颖 高博 +6 位作者 霍佳雨 马春阳 吴戈 李莹莹 陈炳焜 郭玉彬 刘列 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第7期336-342,共7页
We have numerically and experimentally observed the soliton pulsation with obvious breathing behavior in the anomalous fiber laser mode-locked by a nonlinear polarization rotation technique.The numerical study of the ... We have numerically and experimentally observed the soliton pulsation with obvious breathing behavior in the anomalous fiber laser mode-locked by a nonlinear polarization rotation technique.The numerical study of the soliton pulsation with breathing behavior was analyzed through the split-step Fourier method at first,and it was found that the phase difference caused by the polarization controller would affect the breathing characteristics.Then,taking advantage of the dispersive Fourier transform technique,we confirmed the breathing characteristic of soliton pulsation in the same fiber laser as the simulation model experimentally.These results complement the research on the breathing characteristic of soliton pulsation. 展开更多
关键词 soliton pulsation dispersive Fourier transform numerical simulation breathing behavior
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Secure, Efficient and Searchable File System on Distributed Clouds
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作者 Ximing Li Weizhao Chen +2 位作者 yubin guo Sha Ma Qiong Huang 《国际计算机前沿大会会议论文集》 2019年第2期263-266,共4页
Many enterprises and personals are inclining to outsource their data to public clouds, but security and privacy are two critical problems cannot be ignored. The door of cloud provider may be broken, and the data may a... Many enterprises and personals are inclining to outsource their data to public clouds, but security and privacy are two critical problems cannot be ignored. The door of cloud provider may be broken, and the data may also be dug into by providers to find valuable information. In this paper, a secure and efficient storage file (SES FS) system is proposed to distribute files in several clouds and allows users to search the files securely and efficiently. In the proposed system, keywords were transformed into integers and secretly shared in a defined finite field, then the shares were mapped to random numbers in specified random domain in each cloud. Files were encrypted with distinct secret key and scattered within different clouds. Information about keyword/file was secretly shared among cloud providers. Legal users can search in the clouds to find correct encrypted files and reconstruct corresponding secret key. No adversary can find or detect the real file information even they can collude all the servers. Manipulation on shares by one or more clouds can be detected with high probability. The system can also detect malicious servers through introduced virtual points. One interesting property for the scheme is that new keywords can be added easily, which is difficult and usually not efficient for many searchable symmetric encryption systems. Detailed experimental result shows, with tolerable uploading delay, the scheme exhibits excellent performance on data retrieving aspect. 展开更多
关键词 SECRET sharing SECURE searchable FILE system DISTRIBUTED CLOUDS
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