Abnormal interfacial bonding mechanisms of multi-material additive-manufactured tungsten-stainless steel sandwich structure

Tungsten(W)and stainless steel(SS)are well known for the high melting point and good corrosion resistance respectively.Bimetallic W-SS structures would offer potential applications in extreme environments.In this study,a SS→W→SS sandwich structure is fabricated via a special laser powder bed fusion(LPBF)method based on an ultrasonic-assisted powder deposition mechanism.Material characterization of the SS→W interface and W→SS interface was conducted,including microstructure,element distribution,phase distribution,and nano-hardness.A coupled modelling method,combining computational fluid dynamics modelling with discrete element method,simulated the melt pool dynamics and solidification at the material interfaces.The study shows that the interface bonding of SS→W(SS printed on W)is the combined effect of solid-state diffusion with different elemental diffusion rates and grain boundary diffusion.The keyhole mode of the melt pool at the W→SS(W printed on SS)interface makes the pre-printed SS layers repeatedly remelted,causing the liquid W to flow into the sub-surface of the pre-printed SS through the keyhole cavities realizing the bonding of the W→SS interface.The above interfacial bonding behaviours are significantly different from the previously reported bonding mechanism based on the melt pool convection during multiple material LPBF.The abnormal material interfacial bonding behaviours are reported for the first time.

Total flavonoid of Litsea coreana leve exerts anti-oxidative effects and alleviates focal cerebral ischemia/reperfusion injury

In this study, we hypothesized that total flavonoid of Litsea coreana leve （TFLC） protects against focal cerebral ischemia/reperfusion injury. TFLC （25, 50, 100 mg/kg） was administered orally to a rat model of focal ischemia/reperfusion injury, while the free radical scavenging agent, edaravone, was used as a positive control drug. Results of neurological deficit scoring, 2,3,5-triphenyl tetrazolium chloride staining, hematoxylin-eosin staining and biochemical tests showed that TFLC at different doses significantly alleviated cerebral ischemia-induced neurological deficits and histopathological changes, and reduced infarct volume. Moreover, it suppressed the increase in the levels of nitrates plus nitrites, malondialdehyde and lactate dehydrogenase, and it diminished the reduction in glu- tathione, superoxide dismutase and catalase activities induced by cerebral ischemia/reperfusion injury. Compared with edaravone, the protective effects of TFLC at low and medium doses （25, 50 mg/kg） against cerebral ischemia/reperfusion injury were weaker, while the protective effects at high dose （100 mg/kg） were similar. Our experimental findings suggest that TFLC exerts neuroprotective effects against focal cerebral ischemia/reperfusion injury in rats, and that the effects may be asso- ciated with its antioxidant activities.

Topological effect on fluorescence emission of tetraphenylethylene-based metallacages

Herein,we describe the selective formation of a barrel-shaped or a ball-shaped fluorescent metallacage by controlling the shape and stoichiometry of the building blocks.Specifically,the tetraphenylethylene-based donor and two acceptors with different numbers of Pt(Ⅱ)centers were combined via coordination-driven self-assembly.Owing to the differences in the shapes of the assemblies,the resultant ball-shaped metallacage displayed stronger and blue-shifted fluorescence compared to the barrel-shaped one in dilute solutions,while a reversal of fluorescence intensities was observed in the aggregation process.Overall,this work demonstrates that the photophysical properties of supramolecular coordination complexes can be affected by subtle geometrical factors,which can be controlled precisely at the molecular level.

Distinct and relatively mild clinical characteristics of SARS-CoV-2 BA.5 infections against BA.2

Dear Editor,The global pandemic of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant has resulted in its continuous evolution and the emergence of numerous subvariants of Omicron(https://gisaid.org/).Currently,possibly owing to the increased evasion of neutralizing antibodies elicited by previous infection and vaccination and the higher transmissibility,the BA.5 variant has replaced BA.2 variant and dominated the pandemic.