Microwave has been widely used in many fields,including communication,medical treatment and military industry;however,the corresponding generated radiations have been novel hazardous sources of pollution threating hu...Microwave has been widely used in many fields,including communication,medical treatment and military industry;however,the corresponding generated radiations have been novel hazardous sources of pollution threating human’s daily life.Therefore,designing high-performance microwave absorption materials(MAMs)has become an indispensable requirement.Recently,metal-organic frameworks(MOFs)have been considered as one of the most ideal precursor candidates of MAMs because of their tunable structure,high porosity and large specific surface area.Usually,MOF-derived MAMs exhibit excellent electrical conductivity,good magnetism and sufficient defects and interfaces,providing obvious merits in both impedance matching and microwave loss.In this review,the recent research progresses on MOF-derived MAMs were profoundly reviewed,including the categories of MOFs and MOF composites precursors,design principles,preparation methods and the relationship between mechanisms of microwave absorption and microstructures of MAMs.Finally,the current challenges and prospects for future opportunities of MOF-derived MAMs are also discussed.展开更多
As a traditional Chinese herb,dandelion,containing complicated active ingredients which includes polysaccharide,flavonoid,terpene,pigment,phytosterol,coumarin,organic acid and etc,plays significant roles in various ph...As a traditional Chinese herb,dandelion,containing complicated active ingredients which includes polysaccharide,flavonoid,terpene,pigment,phytosterol,coumarin,organic acid and etc,plays significant roles in various physiological activities in organisms.The active ingredients generally interfere in signal transduction of cancer cells,regulate cell cycle and apoptotic protein expression,inhibit cancer cells proliferation and migration and etc,which effectively restrains tumor development and deterioration.This article summarizes the anti-tumor mechanism of five active ingredients in dandelion through paper reading which provides thoughts and references for anti-tumor research.展开更多
To overcome the pain and risk of hypoglycemia in insulin administration,glucose-responsive microneedles have been developed by researchers,which could release insulin according to the blood glucose level.We designed a...To overcome the pain and risk of hypoglycemia in insulin administration,glucose-responsive microneedles have been developed by researchers,which could release insulin according to the blood glucose level.We designed a kind of particles by a reversible addition-fragmentation chain transfer(RAFT)method containing a phenylboronic acid group as the sensor of glucose and carrier of insulin.poly(ethylene glycol)(PEG)-2-(dodecylthio(thiocarbonyl)thio)-2-methylpropionic acid(DDMAT)was synthesized as a macromolecular RAFT agent,which was then reacted with 3-acrylamidophenylboronic acid(AAPBA)to synthesize the block copolymer PEG-b-PAAPBA.Glucose-responsive particles loaded with insulin were prepared by self-assembly based on hydrophilic-hydrophobic interactions.Microneedle patches loaded with glucose-responsive particles were prepared using hyaluronic acid as the substrate.The insulin release behavior of the particles in glucose solutions of 0,100,and 400 mg/dL showed significant glucose responsiveness and good biosafety.The results of blood glucose control experiments in rats indicate that a single microneedle patch can effectively maintain normal blood glucose for over 7 h.展开更多
Mass spectrometry imaging(MSI)has made the spatio-chemical characterization of a broad range of small-molecule metabolites within biological tissues possible.However,available matrix-assisted laser desorption/ionizati...Mass spectrometry imaging(MSI)has made the spatio-chemical characterization of a broad range of small-molecule metabolites within biological tissues possible.However,available matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)suffers from severe background interferences in low-mass ranges and inhomogeneous matrix deposition.Thus,surface-assisted LDI-MS(SALDI-MS)has been an attractive alternative for high-sensitivity detection and imaging of small biomolecules.In this study,we construct a new composite substrate,hydrophobic polydopamine(hPDA)-modified TiO_(2)nanotube(TDNT)coated with plasmonic gold nanoparticle(AuNP-hPDA-TDNT),as a dual-polarity SALDI substrate using an easy and cost-effective fabrication approach.Benefitting from the synergistic effects of TDNT semiconductor and plasmonic PDA modification,this SALDI substrate exhibits superior performance for dual-polarity detection of a vast diversity of small molecules.Highly reduced background interferences,lower detection limits,and spot-to-spot repeatability can be achieved using AuNP-hPDA-TDNT substrates.Due to its unique imprinting performance,various metabolites and lipids can be visualized within jatropha integerrima petals,ginkgo leaves,strawberry fruits,and latent fingerprints.More valuably,the universality of this matrix-free substrate is demonstrated for mapping spatial distribution of lipids within mouse brain tissue sections.Considered together,this AuNP-hPDA-TDNT material is expected to be a promising SALDI substrate in various fields,especially in nanomaterial development and life sciences.展开更多
In HetNets(Heterogeneous Networks),each network is allocated with xed spectrum resource and provides service to its assigned users using speci c RAT(Radio Access Technology).Due to the high dynamics of load distributi...In HetNets(Heterogeneous Networks),each network is allocated with xed spectrum resource and provides service to its assigned users using speci c RAT(Radio Access Technology).Due to the high dynamics of load distribution among di erent networks,simply optimizing the performance of individual network can hardly meet the demands from the dramatically increasing access devices,the consequent upsurge of data trac,and dynamic user QoE(Quality-of-Experience).The deployment of smart networks,which are supported by SRA(Smart Resource Allocation)among di erent networks and CUA(Cognitive User Access)among di erent users,is deemed a promising solution to these challenges.In this paper,we propose a frame-work to transform HetNets to smart networks by leveraging WBD(Wireless Big Data),CR(Cognitive Radio)and NFV(Network Function Virtualization)techniques.CR and NFV support resource slicing in spectrum,physical layers,and network layers,while WBD is used to design intelligent mechanisms for resource mapping and trac prediction through powerful AI(Arti cial Intelligence)methods.We analyze the characteristics of WBD and review possible AI methods to be utilized in smart networks.In particular,the potential of WBD is revealed through high level view on SRA,which intelligently maps radio and network resources to each network for meeting the dynamic trac demand,as well as CUA,which allows mobile users to access the best available network with manageable cost,yet achieving target QoS(Quality-of-Service)or QoE.展开更多
基金Open access funding provided by Shanghai Jiao Tong University.
文摘Microwave has been widely used in many fields,including communication,medical treatment and military industry;however,the corresponding generated radiations have been novel hazardous sources of pollution threating human’s daily life.Therefore,designing high-performance microwave absorption materials(MAMs)has become an indispensable requirement.Recently,metal-organic frameworks(MOFs)have been considered as one of the most ideal precursor candidates of MAMs because of their tunable structure,high porosity and large specific surface area.Usually,MOF-derived MAMs exhibit excellent electrical conductivity,good magnetism and sufficient defects and interfaces,providing obvious merits in both impedance matching and microwave loss.In this review,the recent research progresses on MOF-derived MAMs were profoundly reviewed,including the categories of MOFs and MOF composites precursors,design principles,preparation methods and the relationship between mechanisms of microwave absorption and microstructures of MAMs.Finally,the current challenges and prospects for future opportunities of MOF-derived MAMs are also discussed.
基金This study was supported by Fund of Hubei Provincial Education Department(Q20204508)Fund of Jiangxi Provincial Education Department(GJJ190851)。
文摘As a traditional Chinese herb,dandelion,containing complicated active ingredients which includes polysaccharide,flavonoid,terpene,pigment,phytosterol,coumarin,organic acid and etc,plays significant roles in various physiological activities in organisms.The active ingredients generally interfere in signal transduction of cancer cells,regulate cell cycle and apoptotic protein expression,inhibit cancer cells proliferation and migration and etc,which effectively restrains tumor development and deterioration.This article summarizes the anti-tumor mechanism of five active ingredients in dandelion through paper reading which provides thoughts and references for anti-tumor research.
基金supported by the Natural Science Foundation of Zhejiang Province(No.LHDMZ22H300003)the Science and Technology Program of Zhejiang Province(No.2019C03063),China。
文摘To overcome the pain and risk of hypoglycemia in insulin administration,glucose-responsive microneedles have been developed by researchers,which could release insulin according to the blood glucose level.We designed a kind of particles by a reversible addition-fragmentation chain transfer(RAFT)method containing a phenylboronic acid group as the sensor of glucose and carrier of insulin.poly(ethylene glycol)(PEG)-2-(dodecylthio(thiocarbonyl)thio)-2-methylpropionic acid(DDMAT)was synthesized as a macromolecular RAFT agent,which was then reacted with 3-acrylamidophenylboronic acid(AAPBA)to synthesize the block copolymer PEG-b-PAAPBA.Glucose-responsive particles loaded with insulin were prepared by self-assembly based on hydrophilic-hydrophobic interactions.Microneedle patches loaded with glucose-responsive particles were prepared using hyaluronic acid as the substrate.The insulin release behavior of the particles in glucose solutions of 0,100,and 400 mg/dL showed significant glucose responsiveness and good biosafety.The results of blood glucose control experiments in rats indicate that a single microneedle patch can effectively maintain normal blood glucose for over 7 h.
基金the National Natural Science Foundation of China(Nos.31901911 and 21904142)the Natural Science Foundation of Guangdong Province(Nos.2019A1515011521 and 2022A1515011385)supported by the Young Talent Support Project of Guangzhou Association for Science and Technology(No.QT20220101031).
文摘Mass spectrometry imaging(MSI)has made the spatio-chemical characterization of a broad range of small-molecule metabolites within biological tissues possible.However,available matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)suffers from severe background interferences in low-mass ranges and inhomogeneous matrix deposition.Thus,surface-assisted LDI-MS(SALDI-MS)has been an attractive alternative for high-sensitivity detection and imaging of small biomolecules.In this study,we construct a new composite substrate,hydrophobic polydopamine(hPDA)-modified TiO_(2)nanotube(TDNT)coated with plasmonic gold nanoparticle(AuNP-hPDA-TDNT),as a dual-polarity SALDI substrate using an easy and cost-effective fabrication approach.Benefitting from the synergistic effects of TDNT semiconductor and plasmonic PDA modification,this SALDI substrate exhibits superior performance for dual-polarity detection of a vast diversity of small molecules.Highly reduced background interferences,lower detection limits,and spot-to-spot repeatability can be achieved using AuNP-hPDA-TDNT substrates.Due to its unique imprinting performance,various metabolites and lipids can be visualized within jatropha integerrima petals,ginkgo leaves,strawberry fruits,and latent fingerprints.More valuably,the universality of this matrix-free substrate is demonstrated for mapping spatial distribution of lipids within mouse brain tissue sections.Considered together,this AuNP-hPDA-TDNT material is expected to be a promising SALDI substrate in various fields,especially in nanomaterial development and life sciences.
基金This work is supported by the National Natural Science Foundation of China(Nos.61571100,61631005).
文摘In HetNets(Heterogeneous Networks),each network is allocated with xed spectrum resource and provides service to its assigned users using speci c RAT(Radio Access Technology).Due to the high dynamics of load distribution among di erent networks,simply optimizing the performance of individual network can hardly meet the demands from the dramatically increasing access devices,the consequent upsurge of data trac,and dynamic user QoE(Quality-of-Experience).The deployment of smart networks,which are supported by SRA(Smart Resource Allocation)among di erent networks and CUA(Cognitive User Access)among di erent users,is deemed a promising solution to these challenges.In this paper,we propose a frame-work to transform HetNets to smart networks by leveraging WBD(Wireless Big Data),CR(Cognitive Radio)and NFV(Network Function Virtualization)techniques.CR and NFV support resource slicing in spectrum,physical layers,and network layers,while WBD is used to design intelligent mechanisms for resource mapping and trac prediction through powerful AI(Arti cial Intelligence)methods.We analyze the characteristics of WBD and review possible AI methods to be utilized in smart networks.In particular,the potential of WBD is revealed through high level view on SRA,which intelligently maps radio and network resources to each network for meeting the dynamic trac demand,as well as CUA,which allows mobile users to access the best available network with manageable cost,yet achieving target QoS(Quality-of-Service)or QoE.
